Info: Read More
  • 中药标准品生产商,产品定制服务
  • 牛心果碱

    Reticuline

    牛心果碱
    产品编号 CFN98767
    CAS编号 485-19-8
    分子式 = 分子量 C19H23NO4 = 329.4
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Alkaloids
    植物来源 The roots of Thalictrum foliolosum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    牛心果碱 CFN98767 485-19-8 1mg QQ客服:2159513211
    牛心果碱 CFN98767 485-19-8 5mg QQ客服:2159513211
    牛心果碱 CFN98767 485-19-8 10mg QQ客服:2159513211
    牛心果碱 CFN98767 485-19-8 20mg QQ客服:2159513211
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Julius Kühn-Institut (Germany)
  • Harvard University (USA)
  • University of Indonesia (Indonesia)
  • Medical University of South Carolina (USA)
  • Northeast Normal University Changchun (China)
  • University of Cincinnati (USA)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Wageningen University (Netherlands)
  • University of Madras (India)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Donald Danforth Plant Science Center (USA)
  • Regional Crop Research Institute (Korea)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Monash University Sunway Campus (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • JMSACL2023, 09.002
  • Food Bioscience2023, 56:103311.
  • Nutrients2022, 14(3),695.
  • Kangwon National University2022, 37(1):29-37
  • Industrial Food Engineering2015, 19(4):408-413
  • Molecules.2019, 24(22):E4022
  • Nutrients2022, 14(14)2929
  • Research J. Pharm. and Tech.2020, 13(7):3059-3064.
  • Nutrients.2020, 12(3):595.
  • Exp Parasitol.2018, 194:67-78
  • Institute of Food Science & Technology2021, 45(9).
  • Molecules 2022, 27(3),960.
  • Preprints2021, doi:10.20944
  • FASEB J.2022, 36(7):e22387.
  • Anticancer Res.2018, 38(4):2127-2135
  • Front Plant Sci.2021, 12: 648426.
  • Evid Based Complement Alternat Med.2016, 2016:1230294
  • J Asian Nat Prod Res.2019, 5:1-17
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • bioRxiv - Biochemistry2023, 548213.
  • Int J Mol Sci.2021, 22(2):770.
  • J Int Med Res.2021, 49(7):3000605211032849.
  • J Microbiol Immunol Infect.2021, S1684-1182(21)00142-0.
  • ...
  • 生物活性
    Description: Reticuline is a key compound in the biosynthetic pathway for isoquinoline alkaloids in plants, which include morphine, codeine and berberine. Reticuline possesses potent central nervous system depressant action, it (50-100 mg/kg i.p.) can produce alteration of behaviour pattern, prolongation of pentobarbital-induced sleep, reduction in motor coordination and D-amphetamine-induced hypermotility and suppression of the conditioned avoidance response. (S)-Reticuline can elicit vasorelaxation probably due to the blockade of the L-type voltage-dependent Ca(2+) current in rat aorta, the effect may contribute to the potential cardioprotective efficacy of (S)-reticuline.
    Targets: Calcium Channel
    In vitro:
    Transgenic Res. 2007 Jun;16(3):363-75.
    Knockdown of berberine bridge enzyme by RNAi accumulates (S)-reticuline and activates a silent pathway in cultured California poppy cells.[Pubmed: 17103244 ]
    Reticuline is a key compound in the biosynthetic pathway for isoquinoline alkaloids in plants, which include morphine, codeine and berberine.
    METHODS AND RESULTS:
    We established cultured California poppy (Eschscholzia californica) cells, in which berberine bridge enzyme (BBE) was knocked down by RNA interference, to accumulate the important key intermediate reticuline. Both BBE mRNA accumulation and enzyme activity were effectively suppressed in transgenic cells. In these transgenic cells, end-products of isoquinoline alkaloid biosynthesis, such as sanguinarine, were considerably reduced and reticuline was accumulated at a maximum level of 310 mug/g-fresh weight. In addition, 1 g-fresh weight of these cells secreted significant amounts of reticuline into the medium, with a maximum level of 6 mg/20 mL culture medium. These cells also produced a methylated derivative of reticuline, laudanine, which could scarcely be detected in control cells.
    CONCLUSIONS:
    We discuss the potential application of RNAi technology in metabolic modification and the flexibility of plant secondary metabolism.
    Med Sci Monit. 2005 May;11(5):MS1-5.
    In vivo and in vitro L-DOPA and reticuline exposure increases ganglionic morphine levels.[Pubmed: 15874894]
    Given the presence of morphine, its metabolites and precursors, i.e., reticuline, in mammalian and invertebrate tissues, it has become imperative to determine if exposing tissues to putative opiate alkaloid and dopamine precursors would result in increasing endogenous morphine levels.
    METHODS AND RESULTS:
    Endogenous morphine levels were determined by high performance liquid chromatography coupled to electrochemical detection and radioimmunoassay, following incubation of Mytilus edulis pedal ganglia with reticuline or L-DOPA. Injection of L-DOPA or reticuline into healthy animals was via the foot. Ganglia incubated in vitro with reticuline or L-DOPA for 1 hour exhibited a concentration and time dependent statistically significant increase in their endogenous morphine levels (5.0 +/- 0.47, 3.6 +/- 0.45 ng/ganglion, respectively). Injection of intact, healthy animals with reticuline or L-DOPA also results in significantly higher endogenous ganglionic morphine levels.
    METHODS AND RESULTS:
    Taken together, we show that L-DOPA is being converted to morphine, demonstrating that pedal ganglia can synthesize morphine from these putative precursors in vitro and in vivo. This is the first demonstration of morphine being synthesized in a normal, healthy free living animal.
    In vivo:
    J Ethnopharmacol. 1998 Aug;62(1):57-61.
    Central depressant effects of reticuline extracted from Ocotea duckei in rats and mice.[Pubmed: 9720612]

    METHODS AND RESULTS:
    Neuropharmacological studies were carried out with reticuline, a benzylisoquinoline alkaloid, isolated from Ocotea duckei Vattimo. It was found that reticuline (50-100 mg/kg i.p.) produced alteration of behaviour pattern, prolongation of pentobarbital-induced sleep, reduction in motor coordination and D-amphetamine-induced hypermotility and suppression of the conditioned avoidance response.
    CONCLUSIONS:
    These observations suggest that reticuline possesses potent central nervous system depressant action.
    Planta Med . 2018 Jan;84(1):20-25.
    Anti-Inflammatory Effects of Boldine and Reticuline Isolated from Litsea cubeba through JAK2/STAT3 and NF-κB Signaling Pathways[Pubmed: 28651290]
    Abstract The anti-inflammatory effects of boldine and reticuline isolated from Litsea cubeba were evaluated by using xylene-induced ear edema and carrageenan-induced paw edema in mice and rats. Our results demonstrated that intragastric administration with boldine and reticuline significantly mitigated ear weight in mice and decreased paw volume in rats. A combination administration of boldine (0.5 mg/kg) + reticuline (0.25 mg/kg) resulted in a potentiated inhibition in these two models. In parallel, boldine or reticuline reduce the infiltration of neutrophil leukocytes in rat paw tissue, respectively, and the combination of the two groups performed a better anti-inflammatory activity as shown in histopathologies. Boldine, reticuline, and their combination notably inhibited mRNA expressions of TNF-α, and IL-6 and reduced the phosphorylation levels of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3). Beyond that, their combination also can reduce the phosphorylation levels of p65 and IκBα in the pathological tissues of animals, as observed by real-time PCR and western blot analyses, respectively. These findings indicate for the first time that boldine and reticuline have not only anti-inflammatory activity but also potential synergistic effects in vivo. The underlying mechanism may relate to the inhibition on the expression of pro-inflammatory cytokines, such as TNF-α and IL-6, which may be a consequence of JAK2/STAT3 and NF-κB pathway involvements. This study provides useful data for further exploration and application of boldine and reticuline as potential anti-inflammatory medicines.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0358 mL 15.1791 mL 30.3582 mL 60.7165 mL 75.8956 mL
    5 mM 0.6072 mL 3.0358 mL 6.0716 mL 12.1433 mL 15.1791 mL
    10 mM 0.3036 mL 1.5179 mL 3.0358 mL 6.0716 mL 7.5896 mL
    50 mM 0.0607 mL 0.3036 mL 0.6072 mL 1.2143 mL 1.5179 mL
    100 mM 0.0304 mL 0.1518 mL 0.3036 mL 0.6072 mL 0.759 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    (R)-牛心果碱; (R)-Reticuline CFN95013 3968-19-2 C19H23NO4 = 329.4 5mg QQ客服:3257982914
    藤泊它碱; Tembetarine CFN95542 18446-73-6 C20H26NO4 = 344.4 5mg QQ客服:1457312923
    衡州乌药碱; 乌药碱; Coclaurine CFN98769 486-39-5 C17H19NO3 = 285.3 5mg QQ客服:1413575084
    新化合物X; New compound 10 CFN95343 N/A C23H29NO8 = 447.5 5mg QQ客服:1457312923
    L-(-)-N-去甲亚美罂粟碱; Norarmepavine CFN96773 3195-01-5 C18H21NO3 = 299.37 5mg QQ客服:2056216494
    杏黄罂粟碱; Armepavine CFN93348 524-20-9 C19H23NO3 = 313.39 10mg QQ客服:3257982914
    N-甲基杏黄罂粟碱; N-Methylarmepavine CFN95612 74046-21-2 C20H26NO3+ = 328.4 5mg QQ客服:1413575084
    N-甲基乌药碱; N-Methylcoclaurine CFN96775 5096-70-8 C18H21NO3 = 299.37 5mg QQ客服:1413575084
    N-甲基去氢乌药碱; N-Methyldehydrococlaurine CFN95588 N/A C18H20NO3+ = 298.4 5mg QQ客服:1413575084
    四氢罂粟碱盐酸盐; Tetrahydropapaverine hydrochloride CFN96626 6429-04-5 C20H26ClNO4 = 379.88 5mg QQ客服:1457312923

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产