杏黄罂粟碱

Armepavine

	产品编号	CFN93348
	CAS编号	524-20-9
	分子式 = 分子量	C₁₉H₂₃NO₃ = 313.39
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The herbs of Nelumbo nucifera
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
杏黄罂粟碱	CFN93348	524-20-9	1mg	QQ客服：1413575084
杏黄罂粟碱	CFN93348	524-20-9	5mg	QQ客服：1413575084
杏黄罂粟碱	CFN93348	524-20-9	10mg	QQ客服：1413575084
杏黄罂粟碱	CFN93348	524-20-9	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

The Vancouver Prostate Centre (VPC) (Canada)

Florida International University (USA)

Universidad de Buenos Aires (Argentina)

Universidad de Antioquia (Colombia)

Universidade Federal de Goias (UFG) (Brazil)

Worcester Polytechnic Institute (USA)

Istanbul University (Turkey)

Monash University Malaysia (Malaysia)

Uniwersytet Jagielloński w Krakowie (Poland)

Griffith University (Australia)

University of Wollongong (Australia)

University of Padjajaran (Indonesia)

Indian Institute of Science (India)

University of Otago (New Zealand)

More...

Description:

Armepavine exerts both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBPß pathways. It also shows cytotoxic activity.

Targets:

NF-κB | JunD | C/EBPß

In vitro:

Pharmazie. 2000 Sep;55(9):688-9.

Phytochemical study and cytotoxic activity of alkaloids from Uvaria chamae P. Beauv.[Pubmed: 11031775]

METHODS AND RESULTS:
Phytochemical study of leaves of Uvaria chamae resulted in the isolation for the first time for the genus Uvaria of benzylisoquinoline alkaloids (+)-armepavine (1) and racem. O,O-dimethylcoclaurine (2). The aporphines nornantenine (3), nantenine (4) and corydine (7) are new for the species.
CONCLUSIONS:
The alkaloids were found to express cytotoxic activity against L 929 transformed cells. The highest activity was shown by 1, 3, and 5. At a concentration corresponding to their IC50 against L929 cells, they were nontoxic against mouse thymocytes.

In vivo:

Phytother Res. 2012 Mar;26(3):344-53.

Effects of armepavine against hepatic fibrosis induced by thioacetamide in rats.[Pubmed: 21717514 ]

The aim of this study was to investigate if armepavine (Arm, C₁₉H₂₃O₃N) could exert inhibitory effects against hepatic fibrosis in rats.
METHODS AND RESULTS:
A cell line of rat hepatic stellate cells (HSC-T6) was stimulated with tumour necrosis factor-α (TNF-α) to evaluate the inhibitory effects of Arm. Rats were injected with thioacetamide (TAA; 300 mg/kg, intraperitoneally) thrice a week for 4 weeks to induce hepatic fibrosis, with Arm (3 or 10 mg/kg) given by gavage twice a day. Liver sections were taken for western blotting, fibrosis scoring and immunofluorescence staining. Arm (1-10 µm) concentration-dependently attenuated TNF-α-stimulated: (i) protein expressions of α-smooth muscle actin (α-SMA), collagen type I and angiopoietin-1; (ii) H₂O₂ production; and (iii) NF-κB, JunD and C/EBPß (cytidine-cytidine-adenosine-adenosine-thymidine (CCAAT)/enhancer binding protein-ß (EBPß)) nuclear translocations in HSC-T6 cells. In vivo Arm treatment significantly reduced plasma aspartate transaminase and alanine transaminase levels, hepatic α-SMA expression and collagen contents, and fibrosis scores of TAA-injected rats. Moreover, Arm treatment decreased α-SMA- and NF-κB-positive cells in immunohistochemical staining, and mRNA expression levels of IL-6, TGF-ß1, TIMP-1, col1α2, iNOS and ICAM-1 genes, but up-regulated the metallothionein gene in the livers of TAA-injected rats.
CONCLUSIONS:
Our results indicated that Arm exerted both in vitro and in vivo antifibrotic effects in rats, with inhibition of NF-κB, JunD and C/EBPß pathways.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
木兰箭毒碱; Magnocurarine	CFN93230	6801-40-7	C₁₉H₂₄NO₃ = 314.4	20mg	QQ客服：3257982914
Norjuziphine; Norjuziphine	CFN92409	74119-87-2	C₁₇H₁₉NO₃ = 285.3	5mg	QQ客服：2056216494
Oblongine; Oblongine	CFN97013	60008-01-7	C₁₉H₂₄NO₃ = 314.4	5mg	QQ客服：1457312923
N-Demethylfordianoside; N-Demethylfordianoside	CFN95589	N/A	C₂₃H₃₀NO₈+ = 448.5	10mg	QQ客服：2159513211
牛心果碱; Reticuline	CFN98767	485-19-8	C₁₉H₂₃NO₄ = 329.4	5mg	QQ客服：1457312923
(R)-牛心果碱; (R)-Reticuline	CFN95013	3968-19-2	C₁₉H₂₃NO₄ = 329.4	5mg	QQ客服：1413575084
藤泊它碱; Tembetarine	CFN95542	18446-73-6	C₂₀H₂₆NO₄ = 344.4	5mg	QQ客服：215959384
衡州乌药碱；乌药碱; Coclaurine	CFN98769	486-39-5	C₁₇H₁₉NO₃ = 285.3	5mg	QQ客服：1413575084
新化合物X; New compound 10	CFN95343	N/A	C₂₃H₂₉NO₈ = 447.5	5mg	QQ客服：2056216494
L-(-)-N-去甲亚美罂粟碱; Norarmepavine	CFN96773	3195-01-5	C₁₈H₂₁NO₃ = 299.37	5mg	QQ客服：2056216494

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1909 mL	15.9546 mL	31.9091 mL	63.8182 mL	79.7728 mL
5 mM	0.6382 mL	3.1909 mL	6.3818 mL	12.7636 mL	15.9546 mL
10 mM	0.3191 mL	1.5955 mL	3.1909 mL	6.3818 mL	7.9773 mL
50 mM	0.0638 mL	0.3191 mL	0.6382 mL	1.2764 mL	1.5955 mL
100 mM	0.0319 mL	0.1595 mL	0.3191 mL	0.6382 mL	0.7977 mL

杏黄罂粟碱

Armepavine

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