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  • 衡州乌药碱； 乌药碱

    • 衡州乌药碱； 乌药碱

    Coclaurine

    衡州乌药碱； 乌药碱
    		产品编号 CFN98769
    CAS编号 486-39-5
    分子式 = 分子量 C17H19NO3 = 285.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Coptis chinensis Franch
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    衡州乌药碱； 乌药碱 CFN98769 486-39-5 1mg QQ客服：1413575084
    衡州乌药碱； 乌药碱 CFN98769 486-39-5 5mg QQ客服：1413575084
    衡州乌药碱； 乌药碱 CFN98769 486-39-5 10mg QQ客服：1413575084
    衡州乌药碱； 乌药碱 CFN98769 486-39-5 20mg QQ客服：1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • University of Stirling (United Kingdom)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2023, 28(10):4121.
  • Nutrients.2019, 11(6):E1380
  • J Agric Food Chem.2023, 71(47):18510-18523.
  • Front Endocrinol (Lausanne).2023, 14:1138676.
  • Mol Med Rep.2024, 29(2):26.
  • Int J Pharm.2022, 618:121636.
  • Int J Mol Sci.2023, 24(6):5769.
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  • Dent Mater J.2020, 39(4):690-695
  • Molecules.2023, 28(3):958.
  • Phytomedicine.2021, 2(82):153452
  • Sci Rep. 2018, 10590
  • Mol Biol Rep.2023, 50(5):4029-4038.
  • Plants (Basel).2021, 10(6):1119.
  • Bulletin of Health Research2016, 44(4):279-286
  • Biol Pharm Bull.2017, 40(6):797-806
  • Chemistry of Plant Raw Materials2019, 4:135-147
  • Int J Mol Sci.2024, 25(1):616.
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  • ...
    • 生物活性
    Description: (+)-R-Coclaurine and (+)-S-reticuline show negative inotropic effects, coclaurine derivatives and of paeoniflorin derivatives have neuromuscular blocking actions. D-Coclaurine has a neuroleptic-like property in blocking effects of dopaminergic stimulating agents.
    Targets: Calcium Channel
    In vitro:
    Jpn J Pharmacol. 1989 May;50(1):75-8.
    Inotropic effects of (+/-)-higenamine and its chemically related components, (+)-R-coclaurine and (+)-S-reticuline, contained in the traditional sino-Japanese medicines [Pubmed: 2724702]
    (+/-)-Higenamine (Hig. demethylCoclaurine) is a cardiotonic principle from aconite root. (+)-R-Coclaurine (Coc) and (+)-S-reticuline (Ret) are compounds contained in the dried buds of Magnolia salicifolia MAXIM.
    METHODS AND RESULTS:
    All of these alkaloids possess a common chemical structure: tetrahydroisoquinoline. Coc and Ret showed negative inotropic effects in contrast to the positive inotropic effects of Hig in papillary muscles of guinea pigs. Coc and Ret shifted to the right the concentration-contraction curves of Hig. Hig shifted in parallel to the left the Ca2+ curve, and it tended to shift to the left the isoproterenol (Isp)-induced response curve. In contrast, Coc and Ret inhibited the Ca2+ curve and the low concentration range of the Isp-induced curve, and it potentiated the high concentration ranges of Ca2+ and Isp.
    CONCLUSIONS:
    Coc and Ret showed actions that were reversed in direction to those of Hig, as clearly demonstrated in the Ca2+ curve.
    Planta Med. 1982 Jul;45(3):136.
    The neuromuscular blocking actions of coclaurine derivatives and of paeoniflorin derivatives.[Pubmed: 17396817 ]

    METHODS AND RESULTS:
    The neuromuscular blocking actions of coclaurine derivatives and of paeoniflorin derivatives.
    In vivo:
    J Pharmacobiodyn. 1983 Oct;6(10):793-6.
    Effects of d-coclaurine and d-reticuline, benzyltetrahydroisoquinoline alkaloids, on levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid in the mouse striatum.[Pubmed: 6141236]

    METHODS AND RESULTS:
    An intracerebroventricular injection of d-Coclaurine (50 micrograms), a benzyltetrahydroisoquinoline alkaloid extracted from Magnolia salicifolia, produced a slight increase in 3,4-dihydroxyphenylacetic acid level and a significant increase in homovanillic acid level in the mouse striatum. Another alkaloid d-reticuline (200 micrograms) increased only homovanillic acid level. An intracerebroventricular pretreatment with d-Coclaurine (50 micrograms) did not antagonize suppressive effect of apomorphine on l-dopa formation produced by gamma-butyrolactone (750 mg/kg i.p.) plus aromatic amino acid decarboxylase inhibitor, NSD-1015 (100 mg/kg i.p.).
    CONCLUSIONS:
    These results suggest that d-Coclaurine blocks postsynaptic but not presynaptic dopamine receptors in the mouse striatum.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5051 mL 17.5254 mL 35.0508 mL 70.1016 mL 87.6271 mL
    5 mM 0.701 mL 3.5051 mL 7.0102 mL 14.0203 mL 17.5254 mL
    10 mM 0.3505 mL 1.7525 mL 3.5051 mL 7.0102 mL 8.7627 mL
    50 mM 0.0701 mL 0.3505 mL 0.701 mL 1.402 mL 1.7525 mL
    100 mM 0.0351 mL 0.1753 mL 0.3505 mL 0.701 mL 0.8763 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    牛心果碱; Reticuline CFN98767 485-19-8 C19H23NO4 = 329.4 5mg QQ客服：1413575084
    (R)-牛心果碱; (R)-Reticuline CFN95013 3968-19-2 C19H23NO4 = 329.4 5mg QQ客服：2159513211
    藤泊它碱; Tembetarine CFN95542 18446-73-6 C20H26NO4 = 344.4 5mg QQ客服：1413575084
    衡州乌药碱； 乌药碱; Coclaurine CFN98769 486-39-5 C17H19NO3 = 285.3 5mg QQ客服：1457312923
    新化合物X; New compound 10 CFN95343 N/A C23H29NO8 = 447.5 5mg QQ客服：3257982914
    L-(-)-N-去甲亚美罂粟碱; Norarmepavine CFN96773 3195-01-5 C18H21NO3 = 299.37 5mg QQ客服：2159513211
    杏黄罂粟碱; Armepavine CFN93348 524-20-9 C19H23NO3 = 313.39 10mg QQ客服：3257982914
    N-甲基杏黄罂粟碱; N-Methylarmepavine CFN95612 74046-21-2 C20H26NO3+ = 328.4 5mg QQ客服：3257982914
    N-甲基乌药碱; N-Methylcoclaurine CFN96775 5096-70-8 C18H21NO3 = 299.37 5mg QQ客服：2159513211
    N-甲基去氢乌药碱; N-Methyldehydrococlaurine CFN95588 N/A C18H20NO3+ = 298.4 5mg QQ客服：2159513211

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