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  • L-(-)-N-去甲亚美罂粟碱

    Norarmepavine

    L-(-)-N-去甲亚美罂粟碱
    产品编号 CFN96773
    CAS编号 3195-01-5
    分子式 = 分子量 C18H21NO3 = 299.37
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The stems of Nelumbo nucifera.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    L-(-)-N-去甲亚美罂粟碱 CFN96773 3195-01-5 1mg QQ客服:215959384
    L-(-)-N-去甲亚美罂粟碱 CFN96773 3195-01-5 5mg QQ客服:215959384
    L-(-)-N-去甲亚美罂粟碱 CFN96773 3195-01-5 10mg QQ客服:215959384
    L-(-)-N-去甲亚美罂粟碱 CFN96773 3195-01-5 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Dicle (Turkey)
  • National Cancer Institute (USA)
  • MTT Agrifood Research Finland (Finland)
  • Max-Planck-Insitut (Germany)
  • University of Medicine and Pharmacy (Romania)
  • Institute of Chinese Materia Medica (China)
  • Universit?t Basel (Switzerland)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • University of Vienna (Austria)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Siksha O Anusandhan University (India)
  • University of Illinois (USA)
  • Subang Jaya Medical Centre (Malaysia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • International J of Green Pharmacy2019, 13(3)
  • Molecules.2021, 26(18):5665.
  • J Pharm Biomed Anal2016, 118:183-194
  • Medicina (Kaunas).2020, 56(12):685.
  • J Pharmaceutical and Biomedical Analysis2022, 114631.
  • Antiviral Res.2013, 98(3):386-93
  • Research Square2022, rs.3.rs-1948239
  • Pharmaceuticals (Basel).2022, 15(8):982.
  • J of Physics Conference Series2019, 1349(1)
  • US20170000760 A12016, 42740
  • J Ethnopharmacol.2020, 249:112396
  • Evid Based Complement Alternat Med.2021, 2021:6687513.
  • Universiti Tunku Aboul Rahman2023, 6263.
  • Neurochem Int.2023, 167:105537.
  • Journal of Functional Foods2021, 84:104581
  • Nutrients.2022, 14(19):4170.
  • Br J Pharmacol.2020, 10.1111
  • J-STAGE2015, 249-255
  • Oxid Med Cell Longev.2020, 2020:8887251.
  • Horticulturae2021, 7(1),5.
  • Molecules.2019, 24(4):E709
  • Antioxidants (Basel).2022, 11(12):2327.
  • The Journal of Supercritical Fluids2021, 176:105305.
  • ...
  • 生物活性
    Description: N-norarmepavine shows significant cytotoxic activities against HL-60 carcinoma cell line with inhibitory ratios of 51.43% at concentration of 1 x 10(-5) M. Norarmepavine shows inhibition against Trypanosoma cruzi. D-(+)- N-norarmepavine exhibits significant inhibitory activity towards adenosine 5'-diphosphate (ADP)-, arachidonic acid (AA)-, collagen-, and/or platelet-activating factor (PAF)-induced platelet aggregation.
    Targets: PAFR | Antifection
    In vitro:
    Zhongguo Zhong Yao Za Zhi. 2013 Dec;38(23):4104-8.
    Cytotoxic alkaloids from stems of Nelumbo nucifera.[Pubmed: 24791498]
    Chemical investigation was carried out to study the alkaloids from stems of Nelumbo nucifera and their cytotoxic activities.
    METHODS AND RESULTS:
    The constituents were separated by column chromatography, and their structures were elucidated by spectroscopic data analyses. The isolated compounds were evaluated for their cytotoxic activities by MTr method. Fifteen compounds were isolated from the total alkaloids extract and identified as asimilobine (1), isococlaurine (2), N-acetylNorarmepavine (3), crykonisine (4), velucryptine (5), pycnarrhine (6), liriodenine (7), nuciferine (8), nornuciferine (9), armepavine (10), N-methylasimilobine (11), coclaurine (12), N-Norarmepavine (13), N-methylcoclaurine (14) and lysicamine (15). Compounds 1-7 and 12-15 were isolated from stems of this plant for the first time, and compounds 2-6 were firstly isolated from the family Nelumbonaceae.
    CONCLUSIONS:
    Compounds 7-10, 13 and 14 showed significant cytotoxic activities against HL-60 carcinoma cell line with inhibitory ratios of 51.36%, 59.09%, 52.51%, 53.93%, 51.43%, and 64.31% at concentration of 1 x 10(-5) mol x L(-1), respectively.
    Planta Med. 2006 Oct;72(13):1238-41.
    Effect of isoquinoline alkaloids of different structural types on antiplatelet aggregation in vitro.[Pubmed: 16981134 ]
    Forty-one isoquinoline alkaloids were tested for antiplatelet aggregation effects. Among them, (-)-discretamine (6), protopine (7), ochotensimine (18), O-methylarmepavinemethine (23), lindoldhamine (25), isotetrandrine (26), thalicarpine (27), papaverine (28), and D-(+)- N-norarmepavine (32) exhibited significant inhibitory activity towards adenosine 5'-diphosphate (ADP)-, arachidonic acid (AA)-, collagen-, and/or platelet-activating factor (PAF)-induced platelet aggregation. The results are discussed on the basis of structure-activity relationships.
    Comp Biochem Physiol Pharmacol Toxicol Endocrinol. 1994 Mar;107(3):367-71.
    Trypanocidal effect of boldine and related alkaloids upon several strains of Trypanosoma cruzi.[Pubmed: 8061943]

    METHODS AND RESULTS:
    The alkaloids boldine, glaucine, predicentrine, apomorphine, coclaurine, Norarmepavine and codeine were tested against the epimastigotes of the Tulahuén and LQ strains and the DM 28c clone of Trypanosoma cruzi. The micromolar concentration to inhibit 50% of the culture growth (Tulahuén strain) for apomorphine, glaucine, predicentrine, boldine, Norarmepavine, coclaurine and codeine were 29, 90, 85, 110, 310, 580 and > 1000 respectively. Similar values were obtained with the LQ strain and the DM 28c clone.
    CONCLUSIONS:
    The most active compounds in inhibiting culture growth also inhibited cell respiration, suggesting that these drugs may act by blocking mitochondrial electron transport. The trypanocidal effects of these alkaloids appear to be correlated with their antioxidative activities.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3403 mL 16.7017 mL 33.4035 mL 66.807 mL 83.5087 mL
    5 mM 0.6681 mL 3.3403 mL 6.6807 mL 13.3614 mL 16.7017 mL
    10 mM 0.334 mL 1.6702 mL 3.3403 mL 6.6807 mL 8.3509 mL
    50 mM 0.0668 mL 0.334 mL 0.6681 mL 1.3361 mL 1.6702 mL
    100 mM 0.0334 mL 0.167 mL 0.334 mL 0.6681 mL 0.8351 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    木兰箭毒碱; Magnocurarine CFN93230 6801-40-7 C19H24NO3 = 314.4 20mg QQ客服:1457312923
    Norjuziphine; Norjuziphine CFN92409 74119-87-2 C17H19NO3 = 285.3 5mg QQ客服:2159513211
    Oblongine; Oblongine CFN97013 60008-01-7 C19H24NO3 = 314.4 10mg QQ客服:1457312923
    N-Demethylfordianoside; N-Demethylfordianoside CFN95589 N/A C23H30NO8+ = 448.5 10mg QQ客服:3257982914
    牛心果碱; Reticuline CFN98767 485-19-8 C19H23NO4 = 329.4 5mg QQ客服:2056216494
    (R)-牛心果碱; (R)-Reticuline CFN95013 3968-19-2 C19H23NO4 = 329.4 5mg QQ客服:1413575084
    藤泊它碱; Tembetarine CFN95542 18446-73-6 C20H26NO4 = 344.4 5mg QQ客服:1457312923
    衡州乌药碱; 乌药碱; Coclaurine CFN98769 486-39-5 C17H19NO3 = 285.3 5mg QQ客服:2056216494
    新化合物X; New compound 10 CFN95343 N/A C23H29NO8 = 447.5 5mg QQ客服:3257982914
    L-(-)-N-去甲亚美罂粟碱; Norarmepavine CFN96773 3195-01-5 C18H21NO3 = 299.37 5mg QQ客服:1457312923

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