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  • Oblongine

    Oblongine

    Oblongine
    产品编号 CFN97013
    CAS编号 60008-01-7
    分子式 = 分子量 C19H24NO3 = 314.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The roots of Stephania tetrandra
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Oblongine CFN97013 60008-01-7 1mg QQ客服:1457312923
    Oblongine CFN97013 60008-01-7 5mg QQ客服:1457312923
    Oblongine CFN97013 60008-01-7 10mg QQ客服:1457312923
    Oblongine CFN97013 60008-01-7 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Mahatma Gandhi University (India)
  • Aveiro University (Portugal)
  • Chulalongkorn University (Thailand)
  • Tohoku University (Japan)
  • Kyoto University (Japan)
  • University of Illinois (USA)
  • National Cancer Center Research Institute (Japan)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • The Ohio State University (USA)
  • Macau University of Science and Technology (China)
  • Kamphaengphet Rajabhat University (Thailand)
  • National Hellenic Research Foundation (Greece)
  • FORTH-IMBB (Greece)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2019, 24(17):E3127
  • Life Sci.2021, 270:119074.
  • Front Pharmacol.2020, 11:566490.
  • Phytochemistry Letters2015, 243-247
  • Industrial Crops and Products2022, 188:115638
  • Biochem Biophys Res Commun.2020, 530(1):4-9.
  • Molecules.2021, 26(9):2526.
  • Front Plant Sci.2022, 12:811166.
  • Asian J Beauty Cosmetol2020, 18(3): 265-272.
  • Mol Med Rep.2014, 9(5):1653-9
  • Chemistry of Plant Raw Materials2022, 20220210569.
  • Biomol Ther (Seoul).2023, 31(1):40-47.
  • Molecules.2022, 27(7):2116.
  • Aquaculture2019, 510:392-399
  • Biomol Ther (Seoul).2020, 28(6):542-548.
  • Nat Commun.2021, 12(1):681.
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Biol Pharm Bull.2018, 41(11):1645-1651
  • Research Square2022, rs.3.rs-1948239
  • Auburn University2015, 1-58
  • Journal of Life Science2018, 917-922
  • Front Plant Sci.2017, 8:723
  • Agriculture2022, 12(12), 2173.
  • ...
  • 生物活性
    Description: Oblongine chloride may have potential haemodynamic effects, it can cause a dose-dependent reduction of systolic and diastolic blood pressure, and that these effects are not mediated by β-adrenergic receptor stimulation.
    In vitro:
    Gen Pharmacol. 1993 Mar;24(2):299-304.
    Effects of oblongine chloride, an alkaloid from Leontice leontopetalum on guinea-pig isolated smooth muscle and heart.[Pubmed: 8482513]
    1. The effects of (-)Oblongine chloride, a quaternary alkaloid from Leontice leontopetalum, on guinea-pig isolated ileal longitudinal segments, main pulmonary artery rings, spontaneously-beating atrium and isolated perfused heart were studied.
    METHODS AND RESULTS:
    2. Oblongine chloride (3 x 10(-5)-10(-3) M) caused concentration-dependent relaxation of ileum, an effect which was not blocked by propranolol (10(-6) M) alone or in combination with prazosin (3 x 10(-8) M), or by indomethacin (10(-6) M), but was reduced by desensitization of the preparation by prior exposure to 3 x 10(-5) M ATP and, at high concentrations of Oblongine, by a combination of propranolol and yohimbine (3 x 10(-6) M). 3. Oblongine chloride (10(-5)-3 x 10(-3) M) caused concentration-dependent relaxation of epinephrine-precontracted pulmonary artery. This effect was not affected by propranolol or by indomethacin but was significantly attenuated by pretreatment with 3 x 10(-5) M ATP and potentiated by pretreatment with quinacrine (10(-5) M). 4. Oblongine chloride (10(-5) M-3 x 10(-3) M) caused concentration-dependent increase in the contractility but did not affect the rate of the atrium. Similar effects were obtained with isolated perfused heart except that large concentrations of Oblongine (10(-3), 3 x 10(-3) M) inhibited both contractility and rate of the heart.
    CONCLUSIONS:
    The inotropic effects of Oblongine on the atrium were not blocked by propranolol or indomethacin but were significantly blocked by quinacrine.
    In vivo:
    Phytother. Res., 1995, 9(1):60-3.
    Cardiovascular effects of oblongine chloride, an alkaloid from Leontice leontopetalum, in the anaesthetized guinea-pig[Reference: WebLink]
    The effects of (61)Oblongine chloride, a quaternary alkaloid from Leontice leontopetalum on blood pressure, heart rate and blood flow of the anaesthetized guinea-pig were studied.
    METHODS AND RESULTS:
    At doses ranging from 0.5 mg/kg to 30 mg/kg, i.v., Oblongine chloride caused a dose-dependent reduction of systolic and diastolic blood pressure. These doses were associated with an increase in heart rate. Propranolol (5 mg/kg) failed to block the effects of Oblongine chloride on systolic and diastolic blood pressure but significantly reduced the increase in heart rate observed with low doses (0.5–6 mg/kg) of Oblongine chloride. In doses ranging from 0.05 mg/kg to 0.5 mg/kg, Oblongine chloride caused a small increase in blood flow. Larger doses (1.5, 4.5, 15 and 30 mg/kg) caused an initial decrease followed by an increase of blood flow. The net effect of cumulative doses was an increase in blood flow over the control value.
    CONCLUSIONS:
    These observations suggest that Oblongine chloride may have potential haemodynamic effects and that these effects are not mediated by β-adrenergic receptor stimulation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1807 mL 15.9033 mL 31.8066 mL 63.6132 mL 79.5165 mL
    5 mM 0.6361 mL 3.1807 mL 6.3613 mL 12.7226 mL 15.9033 mL
    10 mM 0.3181 mL 1.5903 mL 3.1807 mL 6.3613 mL 7.9517 mL
    50 mM 0.0636 mL 0.3181 mL 0.6361 mL 1.2723 mL 1.5903 mL
    100 mM 0.0318 mL 0.159 mL 0.3181 mL 0.6361 mL 0.7952 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    N-Demethylfordianoside; N-Demethylfordianoside CFN95589 N/A C23H30NO8+ = 448.5 10mg QQ客服:2056216494
    牛心果碱; Reticuline CFN98767 485-19-8 C19H23NO4 = 329.4 5mg QQ客服:2056216494
    (R)-牛心果碱; (R)-Reticuline CFN95013 3968-19-2 C19H23NO4 = 329.4 5mg QQ客服:3257982914
    藤泊它碱; Tembetarine CFN95542 18446-73-6 C20H26NO4 = 344.4 5mg QQ客服:215959384
    衡州乌药碱; 乌药碱; Coclaurine CFN98769 486-39-5 C17H19NO3 = 285.3 5mg QQ客服:1457312923
    新化合物X; New compound 10 CFN95343 N/A C23H29NO8 = 447.5 5mg QQ客服:2159513211
    L-(-)-N-去甲亚美罂粟碱; Norarmepavine CFN96773 3195-01-5 C18H21NO3 = 299.37 5mg QQ客服:215959384
    杏黄罂粟碱; Armepavine CFN93348 524-20-9 C19H23NO3 = 313.39 10mg QQ客服:3257982914
    N-甲基杏黄罂粟碱; N-Methylarmepavine CFN95612 74046-21-2 C20H26NO3+ = 328.4 5mg QQ客服:3257982914
    N-甲基乌药碱; N-Methylcoclaurine CFN96775 5096-70-8 C18H21NO3 = 299.37 5mg QQ客服:215959384

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