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  • 野黄芩素-7-O-葡萄糖苷

    Scutellarein-7-O-glucoside

    野黄芩素-7-O-葡萄糖苷
    产品编号 CFN95082
    CAS编号 26046-94-6
    分子式 = 分子量 C21H20O11 = 448.4
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Cirsium japonicum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    野黄芩素-7-O-葡萄糖苷 CFN95082 26046-94-6 1mg QQ客服:1413575084
    野黄芩素-7-O-葡萄糖苷 CFN95082 26046-94-6 5mg QQ客服:1413575084
    野黄芩素-7-O-葡萄糖苷 CFN95082 26046-94-6 10mg QQ客服:1413575084
    野黄芩素-7-O-葡萄糖苷 CFN95082 26046-94-6 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Complutense University of Madrid (Spain)
  • Sant Gadge Baba Amravati University (India)
  • Medical University of Gdansk (Poland)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Kyushu University (Japan)
  • Universidade Federal de Santa Catarina (Brazil)
  • University of Sao Paulo (Brazil)
  • University of Wollongong (Australia)
  • MTT Agrifood Research Finland (Finland)
  • University of Limpopo (South Africa)
  • Medizinische Universit?t Wien (Austria)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • University of Padjajaran (Indonesia)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Evid Based Complement Alternat Med.2017, 2017:9764843
  • Horticulture Research2022, uhac276.
  • BMC Complement Med Ther. 2020, 20(1):94.
  • Molecules2022, 27(14),4462
  • Applied Biological Chem. 2020, 26(63).
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • Biol Pharm Bull.2020, 43(10):1534-1541.
  • Molecules.2021, 26(4):816.
  • Front Pharmacol.2021, 12:761922.
  • Evid Based Complement Alternat Med.2016, 2016:1230294
  • Korean Herb. Med. Inf. 2016, 4(1):35-42
  • J Formos Med Assoc.2020, S0929-6646(20)30425-3
  • Tea Res. Ins. Of China2017, 1-12
  • Int J Oncol.2016, 49(4):1497-504
  • Korean J. Medicinal Crop Sci2021, 10:345-352.
  • Molecules.2022, 27(7):2093.
  • Chin. Med.J.Res. Prac.2017, 31(4)
  • Biomed Pharmacother.2019, 116:108987
  • Pharmacological Reports2020, 1-9
  • J Nat Med.2017, 71(4):745-756
  • Chemistr of plant2016, 2016021195
  • J of the Society of Cosmetic Scientists of Korea2018, 44(4):407-417
  • J Cell Mol Med.2020, 24(21):12308-12317.
  • ...
  • 生物活性
    Description: Scutellarein-7-O-glucoside inhibites MMP-2 activity.
    Targets: MMP
    In vitro:
    Microb Cell Fact. 2016 Aug 4;15(1):134.
    Engineering Saccharomyces cerevisiae with the deletion of endogenous glucosidases for the production of flavonoid glucosides.[Pubmed: 27491546 ]
    Glycosylation of flavonoids is a promising approach to improve the pharmacokinetic properties and biological activities of flavonoids. Recently, many efforts such as enzymatic biocatalysis and the engineered Escherichia coli biotransformation have increased the production of flavonoid glucosides. However, the low yield of flavonoid glucosides can not meet the increasing demand for human medical and dietary needs. Saccharomyces cerevisiae is a generally regarded as safe (GRAS) organism that has several attractive characteristics as a metabolic engineering platform for the production of flavonoid glucosides. However, endogenous glucosidases of S. cerevisiae as a whole-cell biocatalyst reversibly hydrolyse the glucosidic bond and hinder the biosynthesis of the desired products. In this study, a model flavonoid, scutellarein, was used to exploit how to enhance the production of flavonoid glucosides in the engineered S. cerevisiae.
    METHODS AND RESULTS:
    To produce flavonoid glucosides, three flavonoid glucosyltransferases (SbGTs) from Scutellaria baicalensis Georgi were successfully expressed in E. coli, and their biochemical characterizations were identified. In addition, to synthesize the flavonoid glucosides in whole-cell S. cerevisiae, SbGT34 was selected for constructing the engineering yeast. Three glucosidase genes (EXG1, SPR1, YIR007W) were knocked out using homologous integration, and the EXG1 gene was determined to be the decisive gene of S. cerevisiae in the process of hydrolysing flavonoid glucosides. To further enhance the potential glycosylation activity of S. cerevisiae, two genes encoding phosphoglucomutase and UTP-glucose-1-phosphate uridylyltransferase involved in the synthetic system of uridine diphosphate glucose were over-expressed in S. cerevisiae. Consequently, approximately 4.8 g (1.2 g/L) of scutellarein-7-O-glucoside (S7G) was produced in 4 L of medium after 54 h of incubation in a 10-L fermenter while being supplied with ~3.5 g of scutellarein.
    CONCLUSIONS:
    The engineered yeast harbouring SbGT with a deletion of glucosidases produced more flavonoid glucosides than strains without a deletion of glucosidases. This platform without glucosidase activity could be used to modify a wide range of valued plant secondary metabolites and to explore of their biological functions using whole-cell S. cerevisiae as a biocatalyst.
    Phytother Res. 2014 Sep;28(9):1399-405.
    The influence of selected flavonoids from the leaves of Cirsium palustre (L.) Scop. on collagen expression in human skin fibroblasts.[Pubmed: 24643916 ]
    Ten flavonoids belonging to the subclasses of flavones, flavanones and aurones were isolated from methanolic extract of Cirsium palustre leaves after multistep chromatographic separation. Their structures were elucidated with spectroscopic methods.
    METHODS AND RESULTS:
    All compounds, except for luteolin 7-O-glucoside, were isolated for the first time. Four compounds-eriodictyol 7-O-glucoside (6), 6-hydroxyluteolin 7-O-glucoside (11), scutellarein-7-O-glucoside (12) and pedalitin (14)-were tested for their effect on collagen expression in normal human dermal fibroblasts. Among them, compound 11 at 40 μM and compound 14, at all concentrations used (1, 20, 40 μM), significantly enhanced the level of total collagen secreted into the medium. Furthermore, compound 11 significantly stimulated type I collagen expression, whereas compound 14 activated type I and III collagen expression at the mRNA level, depending on concentration. MMP-2 activity was inhibited by all study compounds, with the greatest effect recorded with compound 14 at 20 μM. The lack of effect on collagen content in the medium of compound 6- and compound 12-treated cells, besides an increase in COL1A1 and COL1A2 expression, might be caused by diminished expression of HSP47 gene, resulting in decreased procollagen secretion.
    CONCLUSIONS:
    Future study of compounds 11 and 14 for their potential therapeutic use in conditions connected with collagen biosynthesis deficiency is required.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2302 mL 11.1508 mL 22.3015 mL 44.603 mL 55.7538 mL
    5 mM 0.446 mL 2.2302 mL 4.4603 mL 8.9206 mL 11.1508 mL
    10 mM 0.223 mL 1.1151 mL 2.2302 mL 4.4603 mL 5.5754 mL
    50 mM 0.0446 mL 0.223 mL 0.446 mL 0.8921 mL 1.1151 mL
    100 mM 0.0223 mL 0.1115 mL 0.223 mL 0.446 mL 0.5575 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    高车前苷; Homoplantaginin CFN90344 17680-84-1 C22H22O11 = 462.40 20mg QQ客服:3257982914
    高车前素 7-O-新橙皮糖苷; Hispidulin 7-O-neohesperidoside CFN90892 156186-00-4 C28H32O15 = 608.6 5mg QQ客服:1413575084
    Comanthosid B; Comanthosid B CFN91174 70938-60-2 C23H22O12 = 490.4 5mg QQ客服:3257982914
    Comanthosid A; Comanthosid A CFN91173 70938-59-9 C24H24O12 = 504.5 5mg QQ客服:2056216494
    高车前素-4'-O-β-D-葡萄糖苷; Hispidulin 4'-O-beta-D-glucopyranoside CFN91833 244285-12-9 C22H22O11 = 462.4 5mg QQ客服:3257982914
    滨蓟黄甙; Cirsimarin CFN96507 13020-19-4 C23H24O11 = 476.43 5mg QQ客服:215959384
    5,8,4'-三羟基-7-甲氧基黄酮8-O-葡萄糖甙; 5,8,4'-Trihydroxy-7-methoxyflavone 8-O-glucoside CFN97699 710952-13-9 C22H22O11 = 462.41 5mg QQ客服:1413575084
    田蓟苷; Tilianin CFN92764 4291-60-5 C22H22O10 = 446.1 20mg QQ客服:215959384
    蒙花苷; Linarin CFN98738 480-36-4 C28H32O14 = 592.6 20mg QQ客服:1413575084
    金柑苷; Fortunellin CFN70305 20633-93-6 C28H32O14 = 592.6 10mg QQ客服:2056216494

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