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  • 野黄芩苷

    Scutellarin

    野黄芩苷
    产品编号 CFN99112
    CAS编号 27740-01-8
    分子式 = 分子量 C21H18O12 = 462.37
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The roots of Scutellaria baicalensis Georgi.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    野黄芩苷 CFN99112 27740-01-8 10mg QQ客服:1413575084
    野黄芩苷 CFN99112 27740-01-8 20mg QQ客服:1413575084
    野黄芩苷 CFN99112 27740-01-8 50mg QQ客服:1413575084
    野黄芩苷 CFN99112 27740-01-8 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • National Chung Hsing University (Taiwan)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Universite de Lille1 (France)
  • University of Virginia (USA)
  • Medical University of South Carolina (USA)
  • Warszawski Uniwersytet Medyczny (Poland)
  • The Australian National University (Australia)
  • University of Indonesia (Indonesia)
  • Periyar University (India)
  • Calcutta University (India)
  • University of Hull (United Kingdom)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Evid Based Complement Alternat Med.2022, 2022:1307173.
  • Biorxiv2019, 10.1101
  • J Ethnopharmacol.2017, 198:205-213
  • J Drug Delivery Science and Tech.2022, 67:102957.
  • Pharmacognosy Journal2019, 11,6:1235-1241
  • Exp Mol Med.2020, 52(4):629-642.
  • Oncotarget.2017, 8(64):108006-108019
  • J Agric Food Chem.2021, 69(46):14037-14047.
  • J Biochem Mol Toxicol.2017, 31(9)
  • Food and Chemical Toxicology2020, 111221
  • Carbohydrate Polymer Technologies & App.2021, 2:100049.
  • Processes2021, 9(1), 153.
  • Antioxidants (Basel).2020, 9(2): E119
  • Int J Mol Sci.2020, 21(24):9369.
  • Chem Biol Interact.2022, 368:110248.
  • Appl. Sci.2021, 11(19),9343.
  • Kor. J. Herbol.2019, 34(2):59-66
  • SCOPUS.2020, 836-847.
  • Biology (Basel).2020, 9(11):363.
  • J Mater Chem B.2019, 7(39):5896-5919
  • Nutr Cancer.2022, 1-13.
  • J Nat Prod.2018, 81(4):966-975
  • Chinese Pharmacological Bulletin2019, 35(8):1120-1125
  • ...
  • 生物活性
    Description: Scutellarin has many pharmacological effects, such as antioxidant, antitumor, antiviral, neuroprotection and antiinflammatory activities. It down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.
    Targets: P450 (e.g. CYP17) | MMP(e.g.TIMP) | ROS | Calcium Channel | TGF-β/Smad | IL Receptor | TNF-α | p38MAPK | ERK | NOS
    In vitro:
    Life Sci. 2004 Apr 30;74(24):2959-73.
    Protection against hydrogen peroxide-induced cytotoxicity in PC12 cells by scutellarin.[Pubmed: 15051420 ]
    The present study investigated the protective actions of the antioxidant scutellarin against the cytotoxicity produced by exposure to H2O2 in PC12 cells. This was done by assaying for MTT (3,(4,5-dimethylthiazole-2-yl)2,5-diphenyl-tetrazolium bromide) reduction and lactate dehydrogenase (LDH) release.
    METHODS AND RESULTS:
    Reactive oxygen species (ROS) and Ca2+ in cells were evaluated by fluorescent microplate reader using DCFH and Fura 2-AM, respectively, as probes. Lipid peroxidation was quantified using thiobarbituric acid-reactive substances (TBARS). Mitochondrial membrane potential (MMP) was assessed by the retention of rhodamine123 (Rh123), a specific fluorescent cationic dye that is readily sequestered by active mitochondria, depending on their transmembrane potential. The DNA content and percentage of apoptosis were monitored with flow cytometry. Vitamin E, a potent antioxidant, was employed as a comparative agent. Preincubation of PC12 cells with scutellarin prevented cytotoxicity induced by H2O2. Intracellular accumulation of ROS, Ca2+ and products of lipid peroxidation, resulting from H2O2 were significantly reduced by scutellarin. Incubation of cells with H2O2 caused a marked decrease in MMP, which was significantly inhibited by scutellarin. PC12 cells treated with H2O2 underwent apoptotic death as determined by flow cytometric assay. The percentage of this H2O2-induced apoptosis in the cells was decreased in the presence of different concentrations of scutellarin. Scutellarin exhibited significantly higher potency compared to the antioxidant vitamin E.
    CONCLUSIONS:
    The present findings showed that scutellarin attenuated H2O2-induced cytotoxicity, intracellular accumulation of ROS and Ca2+, lipid peroxidation, and loss of MMP and DNA, which may represent the cellular mechanisms for its neuroprotective action.
    Biochem Biophys Res Commun . 2017 Jan 29;483(1):509-515.
    Scutellarin suppresses migration and invasion of human hepatocellular carcinoma by inhibiting the STAT3/Girdin/Akt activity[Pubmed: 27998773]
    Abstract Scutellarin is an active flavone from Erigeron breviscapine (vant) Hand Mass. This study aimed to investigate the potential role of scutellarin in migration and invasion of human hepatocellular carcinoma (HCC) cells and its possible mechanism. In comparison with the vehicle-treated controls, treatment with scutellarin (50 mg/kg/day) for 35 days significantly mitigated the lung and intrahepatic metastasis of HCC tumors in vivo. Scutellarin treatment significantly reduced HepG2 cell viability in a dose-dependent manner, and inhibited migration and invasion of HCC cells in vitro. Scutellarin treatment significantly reduced STAT3 and Girders of actin filaments (Girdin) expression, STAT3 and Akt phosphorylation in HCC cells. Introduction of STAT3 overexpression restored the scutellarin-downregulated Girdin expression, Akt activation, migration and invasion of HCC cells. Furthermore, induction of Girdin overexpression completely abrogated the inhibition of scutellarin on the Akt phosphorylation, migration and invasion of HCC cells. Scutellarin can inhibit HCC cell metastasis in vivo, and migration and invasion in vitro by down-regulating the STAT3/Girdin/Akt signaling. Keywords: Akt; Girdin; Hepatocellular carcinoma; Invasion; STAT3; Scutellarin.
    In vivo:
    Br J Pharmacol. 2011 Feb;162(3):688-700.
    Scutellarin alleviates interstitial fibrosis and cardiac dysfunction of infarct rats by inhibiting TGFβ1 expression and activation of p38-MAPK and ERK1/2.[Pubmed: 20942814]
    Interstitial fibrosis plays a causal role in the development of heart failure after chronic myocardial infarction (MI), and anti-fibrotic therapy represents a promising strategy to mitigate this pathological process. The purpose of this study was to investigate the effect of long-term administration of scutellarin (Scu) on cardiac interstitial fibrosis of myocardial infarct rats and the underlying mechanisms.
    METHODS AND RESULTS:
    Scu was administered to rats that were subjected to coronary artery ligation. Eight weeks later, its effects on cardiac fibrosis were assessed by examining cardiac function and histology. The number and collagen content of cultured cardiac fibroblasts exposed to angiotensin II (Ang II) were determined after the administration of Scu in vitro. Protein expression was detected by Western blot technique, and mRNA levels by quantitative reverse transcription-PCR. The echocardiographic and haemodynamic measurements showed that Scu improved the impaired cardiac function of infarct rats and decreased interstitial fibrosis. Scu inhibited the expression of FN1 and TGFβ1, but produced no effects on inflammatory cytokines (TNFα, IL-1β and IL-6) in the 8 week infarct hearts. Scu inhibited the proliferation and collagen production of cardiac fibroblasts (CFs) and the up-regulation of FN1 and TGFβ1 induced by Ang II. The enhanced phosphorylation of p38-MAPK and ERK1/2 in both infarct cardiac tissue and cultured CFs challenged by Ang II were suppressed by Scu.
    CONCLUSIONS:
    Long-term administration of Scu improved the cardiac function of MI rats by inhibiting interstitial fibrosis, and the mechanisms may involve the suppression of pro-fibrotic cytokine TGFβ1 expression and inhibition of p38 MAPK and ERK1/2 phosphorylation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1628 mL 10.8139 mL 21.6277 mL 43.2554 mL 54.0693 mL
    5 mM 0.4326 mL 2.1628 mL 4.3255 mL 8.6511 mL 10.8139 mL
    10 mM 0.2163 mL 1.0814 mL 2.1628 mL 4.3255 mL 5.4069 mL
    50 mM 0.0433 mL 0.2163 mL 0.4326 mL 0.8651 mL 1.0814 mL
    100 mM 0.0216 mL 0.1081 mL 0.2163 mL 0.4326 mL 0.5407 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    芹菜苷; Apiin CFN90165 26544-34-3 C26H28O14 = 564.49 20mg QQ客服:3257982914
    芹菜素 7-[鼠李糖-(1->2)-半乳糖醛酸苷]; Apigenin 7-[rhamnosyl-(1->2)-galacturonide] CFN95352 124167-97-1 C27H28O15 = 592.5 10mg QQ客服:2159513211
    芹菜素 7-二葡萄糖苷酸; Apigenin 7-diglucuronide CFN91599 74696-01-8 C27H26O17 = 622.5 5mg QQ客服:1457312923
    野漆树苷类似物; New compound 12 (Rhoifolin analog) CFN95371 N/A C33H38O18 = 722.7 5mg QQ客服:215959384
    野漆树苷; Rhoifolin CFN99814 17306-46-6 C27H30O14 = 578.5 20mg QQ客服:1413575084
    异野漆树苷; Isorhoifolin CFN98927 552-57-8 C27H30O14 = 578.5 5mg QQ客服:215959384
    女贞苷; Ligustroflavone CFN90224 260413-62-5 C33H40O18 = 724.67 20mg QQ客服:2159513211
    芹菜素-7-0-(2G-鼠李糖)龙胆糖苷; Apigenin 7-O-(2G-rhamnosyl)gentiobioside CFN90671 174284-20-9 C33H40O19 = 740.67 20mg QQ客服:215959384
    Anisofolin A; Anisofolin A CFN97327 83529-71-9 C39H32O14 = 724.7 5mg QQ客服:1413575084
    野黄芩素-7-O-葡萄糖苷; Scutellarein-7-O-glucoside CFN95082 26046-94-6 C21H20O11 = 448.4 5mg QQ客服:1413575084

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