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  • Anisofolin A

    Anisofolin A

    Anisofolin A
    产品编号 CFN97327
    CAS编号 83529-71-9
    分子式 = 分子量 C39H32O14 = 724.7
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Leonurus japonicus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Anisofolin A CFN97327 83529-71-9 1mg QQ客服:1457312923
    Anisofolin A CFN97327 83529-71-9 5mg QQ客服:1457312923
    Anisofolin A CFN97327 83529-71-9 10mg QQ客服:1457312923
    Anisofolin A CFN97327 83529-71-9 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Chulalongkorn University (Thailand)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Universite de Lille1 (France)
  • S.N.D.T. Women's University (India)
  • Universidade da Beira Interior (Germany)
  • University of Illinois at Chicago (USA)
  • Sant Gadge Baba Amravati University (India)
  • University of Sao Paulo (Brazil)
  • Colorado State University (USA)
  • Hamdard University (India)
  • University of Minnesota (USA)
  • University of Toronto (Canada)
  • Ain Shams University (Egypt)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Ethnopharmacol.2017, 197:157-164
  • J Ethnopharmacol.2016, 192:370-381
  • J Hepatocell Carcinoma.2022, 9:327-341.
  • J Appl Biol Chem.2021, 64(3),263?268
  • Dent Mater J.2020, 39(4):690-695
  • Life Sci.2019, 216:259-270
  • Braz J Med Biol Res.2021, 54(12):e11183.
  • Pharmaceutics.2021, 13(7):1028.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2020, 1149:122123.
  • BMB Rep.2018, 51(5):249-254
  • Int J Mol Sci. 2014, 15(5):8443-57
  • Neurochem Res.2021, s11064-021-03449-0
  • bioRxiv-Pharm.&Toxi.2022, 2022.481203.
  • SBRAS2016, 12
  • Food Funct.2021, 12(4):1469-1481.
  • Molecules.2021, 26(6):1635.
  • Saf Health Work.2019, 10(2):196-204
  • J Ethnopharmacol.2022, 289:115018.
  • Toxicol In Vitro.2018, 52:94-105
  • Integr Med Res.2017, 6(4):395-403
  • The University of Manitoba2021, 35690.
  • J Phys Chem Lett.2021, 12(7):1793-1802.
  • Nutrients.2018, 11(1):E17
  • ...
  • 生物活性
    Description: Anisofolin A has promising antimalarial activity (IC50 4.39 ± 0.25 uM). It has promising antimycobacterium activity [IC50 4.50 ± 0.75 uM (3.31 ug/mL)] against M. tuberculosis H37Ra and at 100 ug/mL, shows 55.6 % inhibition of M. bovis.
    Targets: Antifection
    In vitro:
    Planta Med Lett 2015; 2(01): e35-e38
    Leucas mollissima, a Source of Bioactive Compounds with Antimalarial and Antimycobacterium Activities[Reference: WebLink]

    METHODS AND RESULTS:
    A phytochemical investigation of the acetone extract from the aerial parts of Leucas mollissima afforded one new (−)epi-marmelo lactone, (2 S, 4R, 6 S)-2,6-dimethyl-6 hydroxy-7-ene-4-olide (1), along with five known compounds, schensianol A (2), vanillin (3), β-hydroxy propiovanillone (4), lanost-9(11),25-diene-3β,24β-diol (5), and lanost-9(11),23E(24)-diene-3β,25-diol (6). Similarly, an investigation of the methanol extract of the aerial parts of L. mollissima resulted in the isolation of three known compounds, (+)-syringaresinol (7), Anisofolin A (8), and apigenin 7-O-β-D(− 6′′-p-E-coumaroyl)-glucoside (9). Structure elucidation of the isolated compounds was carried out using detailed analysis of 1D and 2D nuclear magnetic resonance. All compounds were evaluated for antimalarial activity against Plasmodium falciparum (3D7) and for antimycobacterium activity against Mycobacterium tuberculosis H37Ra and Mycobacterium bovis.
    CONCLUSIONS:
    Compound 8 was found to have promising antimalarial activity (IC50 4.39 ± 0.25 μM), promising antimycobacterium activity [IC50 4.50 ± 0.75 μM (3.31 μg/mL)] against M. tuberculosis H37Ra and at 100 μg/mL, showed 55.6 % inhibition of M. bovis. Compound 9 showed moderate inhibition of P. falciparum growth (35 % inhibition at 10 μM) with respect to the positive control atovaquone and 67.4 % inhibition against M. bovis at 100 μg/mL with respect to the positive control rifampicin.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3799 mL 6.8994 mL 13.7988 mL 27.5976 mL 34.497 mL
    5 mM 0.276 mL 1.3799 mL 2.7598 mL 5.5195 mL 6.8994 mL
    10 mM 0.138 mL 0.6899 mL 1.3799 mL 2.7598 mL 3.4497 mL
    50 mM 0.0276 mL 0.138 mL 0.276 mL 0.552 mL 0.6899 mL
    100 mM 0.0138 mL 0.069 mL 0.138 mL 0.276 mL 0.345 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5-(beta-D-吡喃葡萄糖氧基)-7-甲氧基-2-(4-甲氧基苯基)-4H-1-苯并吡喃-4-酮; 7,4-Di-O-methylapigenin 5-O-glucoside CFN99900 197018-71-6 C23H24O10 = 460.4 5mg QQ客服:2056216494
    7,4'-Di-O-methylapigenin 5-O-xylosylglucoside; 7,4'-Di-O-methylapigenin 5-O-xylosylglucoside CFN98099 221257-06-3 C28H32O14 = 592.6 5mg QQ客服:1413575084
    芹菜素-5-O-新橙皮苷; Apigenin 5-O-neohesperidoside CFN96527 850630-40-9 C27H30O14 = 578.52 5mg QQ客服:2159513211
    山茶黄酮苷 A; Camellianin A CFN90992 109232-77-1 C29H32O15 = 620.56 5mg QQ客服:1413575084
    Angeflorin; Angeflorin CFN96365 57498-69-8 C23H24O11 = 476.4 5mg QQ客服:3257982914
    Gelomuloside B; Gelomuloside B CFN96348 149998-39-0 C28H32O15 = 608.6 5mg QQ客服:2159513211
    Gelomuloside A; Gelomuloside A CFN96347 149998-38-9 C29H34O15 = 622.6 5mg QQ客服:215959384
    大蓟苷; Pectolinarin CFN99727 28978-02-1 C29H34O15 = 622.57 20mg QQ客服:3257982914
    Linaroside; Linaroside CFN91714 53452-12-3 C23H24O11 = 476.4 5mg QQ客服:1457312923
    Vicinin 2; Vicinin 2 CFN95249 90456-53-4 C27H30O17 = 626.5 5mg QQ客服:215959384

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