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  • 高车前苷

    Homoplantaginin

    高车前苷
    产品编号 CFN90344
    CAS编号 17680-84-1
    分子式 = 分子量 C22H22O11 = 462.40
    产品纯度 >=98%
    物理属性 Yellow cryst.
    化合物类型 Flavonoids
    植物来源 The herbs of Saluia plebeia R. Br.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    高车前苷 CFN90344 17680-84-1 10mg QQ客服:1457312923
    高车前苷 CFN90344 17680-84-1 20mg QQ客服:1457312923
    高车前苷 CFN90344 17680-84-1 50mg QQ客服:1457312923
    高车前苷 CFN90344 17680-84-1 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Florida International University (USA)
  • University of Medicine and Pharmacy (Romania)
  • MTT Agrifood Research Finland (Finland)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • University of Bonn (Germany)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Griffith University (Australia)
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  • University of Ioannina (Greece)
  • Harvard University (USA)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Shanghai Institute of Organic Chemistry (China)
  • Monash University (Australia)
  • Regional Crop Research Institute (Korea)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Med Sci.2020, 17(5):626-631
  • Biochem Biophys Res Commun.2018, 495(1):1271-1277
  • J Biochem Mol Toxicol.2022, e23211.
  • J Nat Prod.2017, 80(4):854-863
  • Food Res Int.2017, 96:40-45
  • J Sep Sci.2018, 41(9):1938-1946
  • Appl Biol Chem2019, 62:46
  • BMC Complement Altern Med.2019, 19(1):11
  • The Journal of Phytopharmacology2020, 9(1): 1-4
  • J Sep Sci.2019, 42(21):3352-3362
  • J Pain Res.2022, 15:3469-3478.
  • Int J Mol Sci.2021, 22(16):8641.
  • South African Journal of Botany2021, 142:114-123.
  • BMB Rep.2018, 51(5):249-254
  • Pharmacological Reports2020, 1-9
  • Food Bioscience2022, 50:102187.
  • Journal of Food Quality2022, P:13, 6256310.
  • Nutrients.2022, 14(16):3393.
  • J Insect Sci.2020, 20(5):18.
  • Phytomedicine.2015, 22(14):1262-8
  • Toxins (Basel).2022, 14(12):824.
  • Phytomedicine.2016, 23(4):331-9
  • Sci. Rep.2015, 14-23
  • ...
  • 生物活性
    Description: Homoplantaginin shows anti-inflammatory and antioxidant properties, it also has a protective and therapeutic effect on hepatocyte injury and shows potent inhibitory activities against influenza. Homoplantaginin may be used for the prevention and treatment of endothelial dysfunction associated with insulin resistance, it ameliorates endothelial insulin resistance by inhibiting inflammation and modulating cell signalling via the IKKβ/IRS-1/pAkt/peNOS pathway.
    Targets: NF-kB | TNF-α | IL Receptor | IkB | NOS | NO | Akt | SOD | IKK | IRS-1
    In vivo:
    Food Chem Toxicol. 2009 Jul;47(7):1710-5.
    Protective effects of Salvia plebeia compound homoplantaginin on hepatocyte injury.[Pubmed: 19406199]
    Salvia plebeia R. Br is a traditional Chinese herb which has been considered as an inflammatory mediator used for treatment of many infectious diseases including hepatitis. Previously, the compound homoplantaginin was isolated in our group.
    METHODS AND RESULTS:
    Hence, we evaluated the protective effects of homoplantaginin on hepatocyte injury. Homoplantaginin displayed an antioxidant property in a cell-free system and showed IC(50) of reduction level of DPPH radical at 0.35 microg/ml. In human hepatocyte HL-7702 cells exposed to H(2)O(2), the addition of 0.1-100 microg/ml of homoplantaginin, which did not have a toxic effect on cell viability, significantly reduced lactate dehydrogenase (LDH) leakage, and increased glutathione (GSH), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) in supernatant. In vivo assay, we employed the model of Bacillus Calmette-Guérin (BCG)/lipopolysaccharide (LPS)-induced hepatic injury mice to evaluate efficacy of homoplantaginin. Homoplantaginin (25-100mg/kg) significantly reduced the increase in serum alanine aminotranseferase (ALT) and aspartate aminotransferase (AST), decreased the levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1). The same treatment also reduced the content of thiobarbituric acid-reactive substances (TBARS), elevated the levels of GSH, GSH-Px and SOD in hepatic homogenate. The histopathological analysis showed that the grade of liver injury was ameliorated with reduction of inflammatory cells and necrosis of liver cells in homoplantaginin treatment mice.
    CONCLUSIONS:
    These results suggest that homoplantaginin has a protective and therapeutic effect on hepatocyte injury, which might be associated with its antioxidant properties.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1626 mL 10.8131 mL 21.6263 mL 43.2526 mL 54.0657 mL
    5 mM 0.4325 mL 2.1626 mL 4.3253 mL 8.6505 mL 10.8131 mL
    10 mM 0.2163 mL 1.0813 mL 2.1626 mL 4.3253 mL 5.4066 mL
    50 mM 0.0433 mL 0.2163 mL 0.4325 mL 0.8651 mL 1.0813 mL
    100 mM 0.0216 mL 0.1081 mL 0.2163 mL 0.4325 mL 0.5407 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    5-(beta-D-吡喃葡萄糖氧基)-7-甲氧基-2-(4-甲氧基苯基)-4H-1-苯并吡喃-4-酮; 7,4-Di-O-methylapigenin 5-O-glucoside CFN99900 197018-71-6 C23H24O10 = 460.4 5mg QQ客服:215959384
    7,4'-Di-O-methylapigenin 5-O-xylosylglucoside; 7,4'-Di-O-methylapigenin 5-O-xylosylglucoside CFN98099 221257-06-3 C28H32O14 = 592.6 5mg QQ客服:215959384
    芹菜素-5-O-新橙皮苷; Apigenin 5-O-neohesperidoside CFN96527 850630-40-9 C27H30O14 = 578.52 5mg QQ客服:3257982914
    山茶黄酮苷 A; Camellianin A CFN90992 109232-77-1 C29H32O15 = 620.56 5mg QQ客服:215959384
    Angeflorin; Angeflorin CFN96365 57498-69-8 C23H24O11 = 476.4 5mg QQ客服:2159513211
    Gelomuloside B; Gelomuloside B CFN96348 149998-39-0 C28H32O15 = 608.6 5mg QQ客服:3257982914
    Gelomuloside A; Gelomuloside A CFN96347 149998-38-9 C29H34O15 = 622.6 5mg QQ客服:215959384
    大蓟苷; Pectolinarin CFN99727 28978-02-1 C29H34O15 = 622.57 20mg QQ客服:3257982914
    Linaroside; Linaroside CFN91714 53452-12-3 C23H24O11 = 476.4 5mg QQ客服:2056216494
    Vicinin 2; Vicinin 2 CFN95249 90456-53-4 C27H30O17 = 626.5 5mg QQ客服:215959384

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