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  • 染料木素

    Genistein

    染料木素
    产品编号 CFN98681
    CAS编号 446-72-0
    分子式 = 分子量 C15H10O5 = 270.2
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Trifolium pratense L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    染料木素 CFN98681 446-72-0 10mg QQ客服:1413575084
    染料木素 CFN98681 446-72-0 20mg QQ客服:1413575084
    染料木素 CFN98681 446-72-0 50mg QQ客服:1413575084
    染料木素 CFN98681 446-72-0 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Toulouse (France)
  • Michigan State University (USA)
  • Monash University (Australia)
  • Agricultural Research Organization (ARO) (Israel)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Mendel University in Brno (Czech Republic)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Shanghai Institute of Organic Chemistry (China)
  • Max-Planck-Insitut (Germany)
  • University of Toronto (Canada)
  • Medizinische Universit?t Wien (Austria)
  • Northeast Normal University Changchun (China)
  • Amity University (India)
  • The University of Newcastle (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Res Int.2021, 148:110607.
  • Psychopharmacology (Berl).2020, 10.1007
  • BMB Rep.2018, 51(5):249-254
  • J Chem Inf Model.2021, 61(11):5708-5718.
  • Food Res Int.2019, 123:125-134
  • Universitat Stuttgart2022, opus-12200.
  • Cancers (Basel).2023, 15(1):37.
  • Antioxidants (Basel).2022, 11(12):2327.
  • Molecules.2016, 21(6)
  • Phytochem Anal.2021, 32(6):970-981.
  • Chinese Journal of Hospital Pharmacy2020, 40(7)
  • J Nutr Biochem.2022, 107:109064.
  • Neurotoxicology.2022, 91:218-227.
  • Phytomedicine.2018, 38:45-56
  • Nanjing University of Chinese Medicine2022, 345930.
  • J. Korean Wood Sci. Technol.2022, 50(5):338-352.
  • Front Pharmacol.2021, 12:761922.
  • J Enzyme Inhib Med Chem.2019, 34(1):134-143
  • J of Health Science and Alternative Medicine2019, 1(1)
  • The Japan Society for Analytical Chemistry2018, 67(4):201-206
  • FASEB J.2019, 33(2):2026-2036
  • Neurochem Int.2018, 121:114-124
  • Food Control2022, 132:108434.
  • ...
  • 生物活性
    Description: Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM. Genistein has neuroprotective, antitumor effects, it modulates the expression of NF-κB and MAPK (p-38 and ERK1/2), thereby attenuating d-Galactosamine induced fulminant hepatic failure in Wistar rats.
    Targets: TGF-β/Smad | NF-kB | p38MAPK | ERK | Bcl-2/Bax | NOS | COX | NO | PGE | IkB | cAMP | p65 | Beta Amyloid | Estrogen receptor | IL Receptor | IKK | Progestogen receptor
    In vitro:
    Mol Carcinog. 2015 Apr;54(4):301-11.
    Genistein inhibits hepatocellular carcinoma cell migration by reversing the epithelial-mesenchymal transition: partial mediation by the transcription factor NFAT1.[Pubmed: 24243709]
    To investigate the effects and mechanism of Genistein on hepatocellular carcinoma.
    METHODS AND RESULTS:
    Cell counting kit-8 assays showed that Genistein at 3, 6, and 9 µM had no significant cytotoxic effects on HepG2, SMMC-7721, and Bel-7402 cells. Cell scratch and Transwell assays identified that Genistein inhibited migration of three cell lines. In three cell lines, Genistein enhanced E-cadherin and α-catenin, but reduced N-cadherin and Vimentin at both mRNA and protein levels in a dose-dependent manner. Simultaneously, treatment with Genistein suppressed epithelial-mesenchymal transition (EMT) induced by TGF-β. In HepG2 cells, Genistein reduced mRNA, and protein expressions of nuclear factor of activated T cells 1 (NFAT1), Abca3, Autotaxin, CD154, and Cox-2. Phorbol 12-myristate 13-acetate (PMA) and ionomycin enhanced activity of NFAT1, reduced E-cadherin and α-catenin protein levels, and increased protein levels of N-cadherin and Vimentin. Transwell demonstrated that PMA and ionomycin reversed the migration inhibitory effects of Genistein on HepG2 cells. In vivo, Genistein inhibited the intrahepatic metastasis by reversing the EMT, which was correlated with reduced NFAT1 . Genistein inhibited hepatocellular carcinoma cell migration by reversing the EMT, which was partly mediated by NFAT1.
    CONCLUSIONS:
    The fact that EMT can be reversed by Genistein may shed light on the possible mechanisms for its role in liver cancer therapy.
    Virus Res. 2014 Nov 4;192:114-20.
    Genistein inhibits the replication of avian leucosis virus subgroup J in DF-1 cells.[Pubmed: 25197039]
    To investigate the antiviral effects of genistein on the replication of avian leukosis virus subgroup J (ALV-J) in DF-1 cells, the cells were treated with genistein at different time points and the antiviral effects were examined by using a variety of assays.
    METHODS AND RESULTS:
    We determined that genistein strongly inhibited viral gene expression and decreased the viral protein level in the cell supernatant and the cytoplasm without alerting virus receptor expression and viral attachment. We also observed that genistein was not found to interfere with virus entry, but significantly inhibited both viral gene transcriptions at 24h post infection and virus release, which indicate that genistein exerts its inhibitory effects on the late phase of ALV-J replicative cycle.
    CONCLUSIONS:
    These results demonstrate that genistein effectively block ALV-J replication by inhibiting virus transcription and release in DF-1 cells, which may be useful for therapeutic drug design.
    Anticancer Res. 2014 Sep;34(9):4685-92.
    Genistein potentiates the antitumor effect of 5-Fluorouracil by inducing apoptosis and autophagy in human pancreatic cancer cells.[Pubmed: 25202045]
    Although 5-fluorouracil (5-FU)-based combination chemotherapy (i.e. FOLFIRINOX) has demonstrated effectiveness against pancreatic cancer, novel therapeutic strategies must be developed to increase the therapeutic window of these cytotoxic agents. Genistein is a soy-derived isoflavone with pleiotropic biological effects that can enhance the antitumor effect of chemotherapeutic agents.
    METHODS AND RESULTS:
    To understand how genistein potentiates the antitumor effects of 5-FU, we examined apoptosis and autophagy in MIA PaCa-2 human pancreatic cancer cells and their derived xenografts. Apoptosis was evaluated using DNA fragmentation assays, and western blots of poly(ADP ribose)polymerase and caspase-3. Meanwhile, autophagy was evaluated using western blots of microtubule-associated protein light chain 3 (LC3)-I/II, fluorescent microscopy observation of green fluorescent protein-LC3B puncta formation, and acidic vesicular organelle formation using acridine orange staining. Tumors from animal treatment studies were examined for apoptosis and autophagy using the TdT-mediated dUTP nick-end labeling assay and immunohistochemical staining of LC3B, respectively. We observed that genistein increased 5-FU-induced cell death through increased apoptosis, as well as autophagy. The increased autophagy was accompanied by decreased B-cell lymphoma 2 (Bcl2) and increased beclin-1 protein levels. Animal treatment studies supported these observations. The combination of 5-FU and genistein significantly reduced final xenograft tumor volume when compared to 5-FU-alone by inducing apoptosis as well as autophagy.
    CONCLUSIONS:
    Genistein can potentiate the antitumor effect of 5-FU by inducing apoptotic as well as autophagic cell death. These results demonstrate the potential of genistein as an adjuvant therapeutic agent against pancreatic cancer.
    Neurobiol Dis. 2004 Jun;16(1):21-8.
    Neuroprotective effect of genistein against beta amyloid-induced neurotoxicity.[Pubmed: 15207258 ]
    Estrogen is beneficial to patients with Alzheimer's disease (AD) but has a limited clinical use due to its proliferative and oncogenic effects on non-neuronal cells responsive to estrogen.
    METHODS AND RESULTS:
    In an attempt to find an estrogen substitute that retains the beneficial effects of estrogen with minimal side effects, we compared the neuroprotective and proliferative effects of genistein, a selective estrogen receptor (ER) beta-agonist, with those of estrogen. Genistein and 17beta-estradiol showed comparable levels of protection against Abeta-induced deaths of cultured SH-SY5Y human neuroblastoma cells, which were blocked by an estrogen receptor antagonist, ICI 182,780. On the other hand, 17beta-estradiol, but not genistein, induced proliferation of uterine endometrial cells.
    CONCLUSIONS:
    Our results suggest that genistein is a potential alternative to estrogen in the treatment of Alzheimer's disease.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.701 mL 18.5048 mL 37.0096 mL 74.0192 mL 92.5241 mL
    5 mM 0.7402 mL 3.701 mL 7.4019 mL 14.8038 mL 18.5048 mL
    10 mM 0.3701 mL 1.8505 mL 3.701 mL 7.4019 mL 9.2524 mL
    50 mM 0.074 mL 0.3701 mL 0.7402 mL 1.4804 mL 1.8505 mL
    100 mM 0.037 mL 0.185 mL 0.3701 mL 0.7402 mL 0.9252 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    刺桐素 G; Erythrinin G CFN96545 1616592-61-0 C20H18O6 = 354.35 5mg QQ客服:2159513211
    刺桐素 F; Erythrinin F CFN96549 1616592-60-9 C20H18O7 = 370.35 5mg QQ客服:215959384
    刺桐素 D; Erythrinin D CFN96546 1616592-59-6 C21H18O6 = 366.37 5mg QQ客服:2159513211
    异补骨脂香豆素A; Isoficusin A CFN96554 1914963-20-4 C25H24O5 = 404.47 5mg QQ客服:3257982914
    5-甲基-7-甲氧基异黄酮; 5-Methyl-7-methoxyisoflavone CFN93022 82517-12-2 C17H14O3 = 266.29 5mg QQ客服:2056216494
    紫黄檀素; Violanone CFN95385 52250-38-1 C17H16O6 = 316.3 10mg QQ客服:3257982914
    3'-O-甲基紫黄檀素; 3'-O-Methylviolanone CFN95387 56973-42-3 C18H18O6 = 330.3 5mg QQ客服:2056216494
    二氢大豆苷元; Dihydrodaidzein CFN90686 17238-05-0 C15H12O4 = 256.26 10mg QQ客服:2159513211
    大豆苷元; Daidzein CFN98774 486-66-8 C15H10O4 = 254.2 20mg QQ客服:3257982914
    芒柄花黄素; Formononetin CFN99962 485-72-3 C16H12O4 = 268.27 20mg QQ客服:2056216494

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