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  • 甘草宁 G

    Gancaonin G

    甘草宁 G
    产品编号 CFN96524
    CAS编号 126716-34-5
    分子式 = 分子量 C21H20O5 = 352.39
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Glycyrrhiza uralensis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    甘草宁 G CFN96524 126716-34-5 1mg QQ客服:2932563308
    甘草宁 G CFN96524 126716-34-5 5mg QQ客服:2932563308
    甘草宁 G CFN96524 126716-34-5 10mg QQ客服:2932563308
    甘草宁 G CFN96524 126716-34-5 20mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J of Health Science and Alternative Medicine2019, 1(1)
  • J of Applied Pharmaceutical Science2020, 10(1):077-082
  • Asian Pac J Cancer Prev. 2020, 21(4):935-941.
  • Appl. Sci. 2021, 11(17),7829
  • Bull. Natl. Mus. Nat. Sci.2021, 47(2),109-114.
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • Journal of Ginseng Research2019, 10.1016
  • Journal of Ginseng Research2021, 3 June.
  • Int J Food Sci Nutr.2019, 70(7):825-833
  • Molecules.2019, 24(16):E3003
  • Nutrients.2021, 13(8):2901.
  • Phytomedicine.2020, 153440.
  • Antioxidants.2022, 11(3):491.
  • mBio.2020, 11(3):e00686-20.
  • Food Chem.2019, 275:746-753
  • Environ Toxicol Pharmacol.2019, 66:109-115
  • Int J Mol Sci.2020, 21(6):2190.
  • Process Biochemistry2019, 85:106-115
  • Environ Toxicol.2019, 34(12):1354-1362
  • In Vivo.2022, 36(3):1136-1143.
  • Aquaculture2019, 510:392-399
  • J Control Release.2021, 336:159-168.
  • Nat Prod Sci.2016, 22(2)
  • ...
  • 生物活性
    Description: Gancaonin G shows antibacterial effects on the MRSA strains with MIC values of 16 microg/ml, it also shows more moderate antibacterial activity against Streptococcus mutans.
    Targets: Antifection
    In vitro:
    J Nat Prod. 2006 Jan;69(1):121-4.
    Antibacterial compounds from Glycyrrhiza uralensis.[Pubmed: 16441081]

    METHODS AND RESULTS:
    From the roots of Glycyrrhiza uralensis, two new pterocarpenes, glycyrrhizol A (1) and glycyrrhizol B (2), along with four known isoflavonoids, 5-O-methylglycryol (3), isoglycyrol (4), 6,8-diisoprenyl-5,7,4'-trihydroxyisoflavone (5), and gancaonin G (6), were isolated using a bioassay-guided fractionation method. The structures of the new compounds (1and 2) were elucidated by spectroscopic data interpretation. The known compounds (3-6) were identified by comparison of their spectroscopic data with reported values in the literature.
    CONCLUSIONS:
    Glycyrrhizol A (1) and 6,8-diisoprenyl-5,7,4'-trihydroxyisoflavone (5) exhibited potent antibacterial activity against Streptococcus mutans with minimum inhibitory concentrations of 1 and 2 microg/mL, respectively, while glycyrrhizol B (2) and gancaonin G (6) showed more moderate activity.
    Chem Pharm Bull (Tokyo). 2000 Sep;48(9):1286-92.
    Phenolic constituents of licorice. VIII. Structures of glicophenone and glicoisoflavanone, and effects of licorice phenolics on methicillin-resistant Staphylococcus aureus.[Pubmed: 10993226]

    METHODS AND RESULTS:
    Two new phenolic compounds, glicophenone (1) and glicoisoflavanone (2), were isolated from commercial licorice, and their structures were elucidated on the basis of spectroscopic data. Antibacterial assays of licorice phenolics for Staphylococcus aureus, including four strains of methicillin-resistant S. aureus (MRSA), and also for Escherichia coli K12 and Pseudomonas aeruginosa PAO1, were then examined. Two compounds among them, 8-(gamma,gamma-dimethylallyl)-wighteone (21) and 3'-(gamma,gamma-dimethylallyl)-kievitone (28), showed remarkable antibacterial effects [minimum inhibitory concentrations (MICs), 8 microg/ml on the MRSA strains and methicillin-sensitive S. aureus. Licochalcone A (14), Gancaonin G (20), isoangustone A (24), glyasperins C (30) and D (31), glabridin, (32), licoricidin (33), glycycoumarin (34) and licocoumarone (40) showed antibacterial effects on the MRSA strains with MIC values of 16 microg/ml. Effects on the beta-lactam resistance of the MRSA strains were also examined, and licoricidin (33) noticeably decreased the resistance of the MRSA strains against oxacillin, as shown by the reduction in the MICs of oxacillin (lower than 1/128-1/1000 in the presence of 8 microg/ml of 33, and 1/8-1/32 in the presence of 4 microg/ml of 33).
    CONCLUSIONS:
    Mechanistic study suggested that 33 does not inhibit the formation of penicillin-binding protein 2' (PBP2'), but affects the enzymatic function of PBP2'.
    In vivo:
    J Nat Prod. 2014 Mar 28;77(3):521-6.
    Pyrano-isoflavans from Glycyrrhiza uralensis with antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis.[Pubmed: 24479468 ]

    METHODS AND RESULTS:
    Continuing investigation of fractions from a supercritical fluid extract of Chinese licorice (Glycyrrhiza uralensis) roots has led to the isolation of 12 phenolic compounds, of which seven were described previously from this extract. In addition to these seven metabolites, four known components, 1-methoxyerythrabyssin II (4), 6,8-diprenylgenistein, Gancaonin G (5), and isoglycyrol (6), and one new isoflavan, licorisoflavan C (7), were characterized from this material for the first time. Treatment of licoricidin (1) with palladium chloride afforded larger amounts of 7 and also yielded two new isoflavans, licorisoflavan D (8), which was subsequently detected in the licorice extract, and licorisoflavan E (9). Compounds 1-9 were evaluated for their antibacterial activities against the cariogenic Streptococcus mutans and the periodontopathogenic Porphyromonas gingivalis.
    CONCLUSIONS:
    Licoricidin (1), licorisoflavan A (2), and 7-9 showed antibacterial activity against P. gingivalis (MICs of 1.56-12.5 μg/mL). The most potent activity against S. mutans was obtained with 7 (MIC of 6.25 μg/mL), followed by 1 and 9 (MIC of 12.5 μg/mL). This study provides further evidence for the therapeutic potential of licorice extracts for the treatment and prevention of oral infections.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8378 mL 14.1888 mL 28.3776 mL 56.7553 mL 70.9441 mL
    5 mM 0.5676 mL 2.8378 mL 5.6755 mL 11.3511 mL 14.1888 mL
    10 mM 0.2838 mL 1.4189 mL 2.8378 mL 5.6755 mL 7.0944 mL
    50 mM 0.0568 mL 0.2838 mL 0.5676 mL 1.1351 mL 1.4189 mL
    100 mM 0.0284 mL 0.1419 mL 0.2838 mL 0.5676 mL 0.7094 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Orobanone; Orobanone CFN92654 78916-35-5 C15H20O = 216.3 5mg QQ客服:215959384
    乙酸间甲苯酯; Acetic acid m-cresyl ester CFN70044 122-46-3 C9H10O2 = 150.1 20mg QQ客服:2932563308
    商陆皂苷甲; Esculentoside A CFN98162 65497-07-6 C42H66O16 = 826.96 20mg QQ客服:3257982914
    磁麻苷; Cymarin CFN70386 508-77-0 C30H44O9 = 548.7 5mg QQ客服:2159513211

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