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  • 黄豆黄素

    Glycitein

    黄豆黄素
    产品编号 CFN99106
    CAS编号 40957-83-3
    分子式 = 分子量 C16H12O5 = 284.26
    产品纯度 >=98%
    物理属性 Yellow Powder
    化合物类型 Flavonoids
    植物来源 The fruits of Glycine max (L.) merr.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    黄豆黄素 CFN99106 40957-83-3 10mg QQ客服:3257982914
    黄豆黄素 CFN99106 40957-83-3 20mg QQ客服:3257982914
    黄豆黄素 CFN99106 40957-83-3 50mg QQ客服:3257982914
    黄豆黄素 CFN99106 40957-83-3 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Almansora University (Egypt)
  • Nanjing University of Chinese Medicine (China)
  • University of Oslo (Norway)
  • S.N.D.T. Women's University (India)
  • Macau University of Science and Technology (China)
  • Washington State University (USA)
  • Kyushu University (Japan)
  • Universidad Veracuzana (Mexico)
  • Universidad de Antioquia (Colombia)
  • Auburn University (USA)
  • University of Amsterdam (Netherlands)
  • Universiti Sains Malaysia (Malaysia)
  • National Hellenic Research Foundation (Greece)
  • Sanford Burnham Medical Research Institute (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytomedicine.2019, 59:152785
  • Int J Mol Sci.2015, 16(8):18396-411
  • Bulletin of Health Research2016, 44(4):279-286
  • Molecules2022, 27(9):2827.
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • Journal of Functional Foods2019, 52:430-441
  • Molecules 2021, 26(4),1092.
  • Phytomedicine.2019, 65:153089
  • Cancer Sci.2022, 113(4):1406-1416.
  • Primary and Industrial.2018, 52(11)
  • Oncol Lett.2020, 20(4):122.
  • J Ginseng Res.2020, 44(4):611-618.
  • Food Res Int.2022, 157:111207.
  • J Ginseng Res.2022, 46(1):104-114.
  • Plant Cell Tiss Org2017, 479-486
  • Foods.2022, 11(12):1708.
  • Horticulturae2021, 7(1),5.
  • J Hepatocell Carcinoma.2022, 9:327-341.
  • Drug Chem Toxicol.2020, 1-14.
  • Chem Res Toxicol. 2022, acs.chemrestox.2c00049.
  • Food Funct.2022, 13(13):6923-6933.
  • Food Funct.2022, doi: 10.1039
  • Preprints2021, doi:10.20944
  • ...
  • 生物活性
    Description: Gycitein has antioxidant, weak estrogenic, anti-invasion, and anti-proliferation activities, it has potentiol to prevent Abeta associated neurodegenerative disorders, and atherosclerotic cardiovascular diseases. It is a potent activator of ERK1/2, decreases RWPE-1 cell proliferation, it induces ERK1/2 activation was dependent, in part, on tyrosine kinase activity associated with vascular endothelial growth factor receptor (VEGFR).
    Targets: PDGFR | MMP(e.g.TIMP) | NF-kB | AP-1 | ROS | JNK | ERK | VEGFR
    In vitro:
    J Nutr. 2001 Apr;131(4):1154-8.
    Genistein, daidzein and glycitein inhibit growth and DNA synthesis of aortic smooth muscle cells from stroke-prone spontaneously hypertensive rats.[Pubmed: 11285318]
    Recent studies have reported that estrogen replacement therapy (ERT) reduces the risk of cardiovascular diseases in postmenopausal women. However, mechanisms responsible for this effect are not yet completely understood, and ERT is associated with carcinogenic side effects in women and feminizing effects in men.
    METHODS AND RESULTS:
    Because soybean isoflavones, a group of natural phytoestrogens, have only weak estrogenic activity and are not known to have side effects such as carcinogenesis and feminization, we evaluated the effects of genistein, daidzein and glycitein on the growth and DNA synthesis of aortic smooth muscle cells (SMC) from stroke-prone spontaneously hypertensive rats (SHRSP). SMC were cultured in dishes and proliferated on 10% dextran-coated charcoal/fetal bovine serum, and then treated with 0.1-30 micromol/L of genistein, daidzein or glycitein to investigate cell proliferation (cell number) and DNA synthesis (cell proliferation ELISA system), respectively. We also studied their effects on platelet-derived growth factor (PDGF)-BB (20 microg/L)-induced SMC proliferation. Soybean isoflavones inhibited proliferation and DNA synthesis of SMC from SHRSP in a concentration-dependent manner. Inhibition was significant at 3 micromol/L of genistein and 10 micromol/L of both daidzein and glycitein. For significant inhibition of PDGF-BB-induced SMC proliferation, concentrations as low as 0.1 micromol/L of each isoflavone were effective.
    CONCLUSIONS:
    These isoflavones, with their inhibitory effects on natural and PDGF-BB-induced SMC proliferation, may be useful in attenuatating such proliferation, a basic mechanism involved in atherosclerotic vascular change, thereby preventing atherosclerotic cardiovascular diseases.
    Free Radic Res. 2007 Jun;41(6):720-9.
    Inhibitory effects of glycitein on hydrogen peroxide induced cell damage by scavenging reactive oxygen species and inhibiting c-Jun N-terminal kinase.[Pubmed: 17516245 ]
    The present study investigated the cytoprotective properties of glycitein, a metabolite formed by the transformation of glycitin by intestinal microflora, against oxidative stress.
    METHODS AND RESULTS:
    Glycitein was found to scavenge intracellular reactive oxygen species (ROS), and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and thereby preventing lipid peroxidation and DNA damage. Glycitein inhibited apoptosis of Chinese hamster lung fibroblast (V79-4) cells exposed to hydrogen peroxide (H(2)O(2)) via radical scavenging activity. Glycitein abrogated the activation of c-Jun N-terminal kinase (JNK) induced by H(2)O(2) treatment and inhibited DNA binding activity of activator protein-1 (AP-1), a downstream transcription factor of JNK.
    CONCLUSIONS:
    Taken together, these findings suggest that glycitein protected H(2)O(2) induced cell death in V79-4 cells by inhibiting ROS generation and JNK activation.
    In vivo:
    Molecules. 2010 Jul 29;15(8):5153-61.
    Synthesis of beta-maltooligosaccharides of glycitein and daidzein and their anti-oxidant and anti-allergic activities.[Pubmed: 20714292]

    METHODS AND RESULTS:
    The production of beta-maltooligosaccharides of glycitein and daidzein using Lactobacillus delbrueckii and cyclodextrin glucanotransferase (CGTase) as biocatalysts was investigated. The cells of L. delbrueckii glucosylated glycitein and daidzein to give their corresponding 4'- and 7-O-beta-glucosides. The beta-glucosides of glycitein and daidzein were converted into the corresponding beta-maltooligosides by CGTase.
    CONCLUSIONS:
    The 7-O-beta-glucosides of glycitein and daidzein and 7-O-beta-maltoside of glycitein showed inhibitory effects on IgE antibody production. On the other hand, beta-glucosides of glycitein and daidzein exerted 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging activity and supeoxide-radical scavenging activity.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5179 mL 17.5895 mL 35.1791 mL 70.3581 mL 87.9477 mL
    5 mM 0.7036 mL 3.5179 mL 7.0358 mL 14.0716 mL 17.5895 mL
    10 mM 0.3518 mL 1.759 mL 3.5179 mL 7.0358 mL 8.7948 mL
    50 mM 0.0704 mL 0.3518 mL 0.7036 mL 1.4072 mL 1.759 mL
    100 mM 0.0352 mL 0.1759 mL 0.3518 mL 0.7036 mL 0.8795 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    对映-11,16-环氧-15-羟基贝壳杉-19-酸; ent-11,16-Epoxy-15-hydroxykauran-19-oic acid CFN97263 77658-46-9 C20H30O4 = 334.5 5mg QQ客服:215959384
    郁金二酮; Curcumadione CFN92617 116425-36-6 C15H22O2 = 234.3 5mg QQ客服:2932563308
    芦荟大黄素-3-(羟甲基)-O-β-D-葡萄糖苷; Aloe-emodin-3-(hydroxymethyl)-O-beta-D-glucopyranoside CFN91110 50488-89-6 C21H20O10 = 432.38 5mg QQ客服:1148253675
    Blepharotriol; Blepharotriol CFN91916 849590-42-7 C29H38O6 = 482.61 5mg QQ客服:1413575084

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