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  • 鸢尾甲黄素A

    Iristectorigenin A

    鸢尾甲黄素A
    产品编号 CFN91672
    CAS编号 39012-01-6
    分子式 = 分子量 C17H14O7 = 330.29
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The rhizomes of Belamcanda chinensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    鸢尾甲黄素A CFN91672 39012-01-6 1mg QQ客服:215959384
    鸢尾甲黄素A CFN91672 39012-01-6 5mg QQ客服:215959384
    鸢尾甲黄素A CFN91672 39012-01-6 10mg QQ客服:215959384
    鸢尾甲黄素A CFN91672 39012-01-6 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Yakugaku Zasshi.2018, 138(4):571-579
  • J Med Food.2019, 22(10):1067-1077
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1113:1-13
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  • Nutrients.2019, 11(11):E2694
  • Molecules.2019, 24(6):E1177
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  • Molecules.2022, 27(13):4227.
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  • Front Pharmacol.2021, 12:615157.
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  • Biomolecules.2019, 9(11):E696
  • Arch Toxicol.2017, 91(10):3225-3245
  • Eur J Pharmacol.2020, 889:173589.
  • Pharmaceuticals (Basel).2021, 14(8):742.
  • Advances in Traditional Medicine2020, 10.1007
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  • J Asian Nat Prod Res.2019, 5:1-17
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  • ...
  • 生物活性
    Description: Iristectorigenin A is a natural isoflavone isolated from B. chinensis rhizomes. Iristectorigenin A shows antioxidant hepatoprotective activity.
    In vitro:
    Arch Pharm Res . 2017 Apr;40(4):524-535.
    Methyl caffeate and some plant constituents inhibit age-related inflammation: effects on senescence-associated secretory phenotype (SASP) formation[Pubmed: 28299617]
    During aging, cells secrete molecules called senescence-associated secretory phenotype (SASP). They constitute chronic low-grade inflammation environment to adjacent cells and tissues. In order to find inhibiting agents of SASP formation, 113 plant constituents were incubated with BJ fibroblasts for 6 days after treatment with bleomycin. Several plant constituents showed considerable inhibition of IL-6 production, a representative SASP marker. These plant constituents included anthraquinones such as aurantio-obtusin, flavonoids including astragalin, iristectorigenin A, iristectorigenin B, linarin, lignans including lariciresinol 9-O-glucoside and eleutheroside E, phenylpropanoids such as caffeic acid and methyl caffeate, steroid (ophiopogonin), and others like centauroside, rhoifolin and scoparone. In particular, methyl caffeate down-regulated SASP factors such as IL-1α, IL-1β, IL-6, IL-8, GM-CSF, CXCL1, MCP-2, and MMP-3. Inhibition of these SASP mRNA expression levels also coincided with the reduction of IκBζ expression and NF-κB p65 activation without affecting the expression levels of senescence markers, p21 or pRb. Taken together, the present study demonstrated that methyl caffeate might be a specific and strong inhibitor of SASP production without affecting the aging process. Its action mechanisms involve the reduction of IκBζ expression and NF-κB p65 activation. Therefore, this compound might be effective in alleviating chronic low-grade inflammation linked to age-related degenerative disorders.
    Phytomedicine . 2014 Sep 15;21(10):1202-1207.
    Phytomedicine . 2014 Sep 15;21(10):1202-7. doi: 10.1016/j.phymed.2014.04.007. Epub 2014 May 28. Hepatoprotective activity of LC-ESI-MS standardized Iris spuria rhizome extract on its main bioactive constituents[Pubmed: 24877715]
    The study was designed to evaluate the hepatoprotective activity of Iris spuria against paracetamol induced toxicity at two different doses 100 and 200 mg/kg. The extract showed significant protective activity (p>0.01) at both the doses in dose dependent manner. Administration of the plant extract restored the paracetamol induced elevated levels of serum marker and distorted hepatic tissue architecture. The lipid peroxides (LPO) and glutathione (GSH) levels were also restored towards normal in liver tissue significantly. The main chemical constituents of the extract identified by the liquid chromatography-tandem mass spectrometry (LC-ESI-MSMS) were found to be flavones and isoflavonoids. Tectoridin and iristectorigenin A were the principal compounds present in the methanolic extract of Iris spuria.
    Arch Pharm Res . 1999 Feb;22(1):18-24
    Inhibition of cyclooxygenase/lipoxygenase from human platelets by polyhydroxylated/methoxylated flavonoids isolated from medicinal plants[Pubmed: 10071954]
    Various flavonoid derivatives were previously reported to possess the inhibitory activity on cyclooxygenase/lipoxygenase. And these properties of flavonoids might contribute to their anti-inflammatory activity in vivo. In this study, several polyhydroxylated/methoxylated flavonoid derivatives such as oroxylin A, wogonin, skullcapflavone II, tectorigenin and iristectorigenin A were isolated from the medicinal plants. These compounds were evaluated for their inhibitory effects on cyclooxygenase/lipoxygenase from the homogenate of human platelets in vitro. It was found that isoflavones including daidzein and tectorigenin possessed the inhibitory activity on cyclooxygenase, although the potency of inhibition was far less than that of indomethacin. In addition, oroxylin A, baicalein and wogonin inhibited 12-lipoxygenase activity without affecting cyclooxygenase, which suggested that 5,6,7- or 5,7,8-trisubstitutions of A-ring of flavone gave favorable results. The IC50 values of oroxylin A and NDGA against 12-lipoxygenase were found to be 100 and 1.5 microM, respectively.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0276 mL 15.1382 mL 30.2764 mL 60.5528 mL 75.6911 mL
    5 mM 0.6055 mL 3.0276 mL 6.0553 mL 12.1106 mL 15.1382 mL
    10 mM 0.3028 mL 1.5138 mL 3.0276 mL 6.0553 mL 7.5691 mL
    50 mM 0.0606 mL 0.3028 mL 0.6055 mL 1.2111 mL 1.5138 mL
    100 mM 0.0303 mL 0.1514 mL 0.3028 mL 0.6055 mL 0.7569 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    大豆苷元; Daidzein CFN98774 486-66-8 C15H10O4 = 254.2 20mg QQ客服:1413575084
    芒柄花黄素; Formononetin CFN99962 485-72-3 C16H12O4 = 268.27 20mg QQ客服:3257982914
    异刺芒柄花素; Isoformononetin CFN95024 486-63-5 C16H12O4 = 268.3 5mg QQ客服:1148253675
    大豆苷元甲醚; Daidzein dimethyl ether CFN90873 1157-39-7 C17H14O4 = 282.3 20mg QQ客服:215959384
    染料木素; Genistein CFN98681 446-72-0 C15H10O5 = 270.2 20mg QQ客服:3257982914
    5-O-Methylgenistein; 5-O-Methylgenistein CFN89437 4569-98-6 C16H12O5 = 284.26 5mg QQ客服:3257982914
    鹰嘴豆芽素A; Biochanin A CFN99734 491-80-5 C16H12O5 = 284.26 20mg QQ客服:3257982914
    4’7-二甲氧基-5-羟基异黄酮; 7-O-Methylbiochanin A CFN91010 34086-51-6 C17H14O5 = 298.3 10mg QQ客服:1413575084
    樱黄素; Prunetin CFN90189 552-59-0 C16H12O5 = 284.26 20mg QQ客服:2159513211
    6-Methylgenistein; 6-Methylgenistein CFN96540 97575-49-0 C16H12O5 = 284.26 5mg QQ客服:2932563308

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