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  • 6,7,4'-三羟基异黄酮

    6,7,4'-Trihydroxyisoflavone

    6,7,4'-三羟基异黄酮
    产品编号 CFN90796
    CAS编号 17817-31-1
    分子式 = 分子量 C15H10O5 = 270.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The seeds of Glycine max
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    6,7,4'-三羟基异黄酮 CFN90796 17817-31-1 1mg QQ客服:3257982914
    6,7,4'-三羟基异黄酮 CFN90796 17817-31-1 5mg QQ客服:3257982914
    6,7,4'-三羟基异黄酮 CFN90796 17817-31-1 10mg QQ客服:3257982914
    6,7,4'-三羟基异黄酮 CFN90796 17817-31-1 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • National Cancer Center Research Institute (Japan)
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  • University of Melbourne (Australia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Tea Res. Ins. Of China2017, 1-12
  • Int J Mol Sci.2021, 22(9):5012.
  • Research on Crops.2017, 18(3):569
  • Pharm Biol.2021, 59(1):134-145.
  • Int J Mol Sci.2020, 21(9):3239.
  • Cell Rep.2022, 39(1):110643.
  • Evid Based Complement Alternat Med.2017, 2017:7383104
  • Pharmaceuticals (Basel).2022, 15(5):591.
  • Mol Pharm.2018, 15(8):3285-3296
  • Food and Bioprocess Technology2017, 10(6):1074-1092
  • Evid Based Complement Alternat Med.2017, 2017:6360836
  • Evid Based Complement Alternat Med.2018, 2018:1073509
  • ACS Synth Biol.2020, 9(9):2282-2290.
  • Food Chemistry: X.2022, 2022.100270
  • Natural Product Communications2020, doi: 10.1177.
  • Acta Pharm Sin B.2015, 5(4):323-9.
  • Evid Based Complement Alternat Med.2021, 2021:8847358.
  • J Agric Food Chem.2018, 66(1):351-358
  • The Journal of Internal Korean Medicine2015, 36(4):486-497
  • Molecules.2018, 23(12):E3103
  • J Ethnopharmacol.2022, 289:115018.
  • Bull. Pharm. Sci., Assiut University2020, 43(2):149-155.
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • ...
  • 生物活性
    Description: 6,7,4'-Trihydroxyisoflavone, is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities. 6,7,4'-trihydroxyisoflavone, suppresses adipogenesis in 3T3-L1 preadipocytes via ATP-competitive inhibition of PI3K.
    Targets: ERK | MEK | JNK | p38MAPK | PKC | CDK | PI3K | ATP
    In vitro:
    Mol Nutr Food Res. 2013 Aug;57(8):1446-55. doi: 10.1002/mnfr.201200593. Epub 2013 Jun 4.
    A metabolite of daidzein, 6,7,4'-trihydroxyisoflavone, suppresses adipogenesis in 3T3-L1 preadipocytes via ATP-competitive inhibition of PI3K.[Pubmed: 23737351]
    Daidzein is one of the major soy isoflavones. Following ingestion, daidzein is readily metabolized in the liver and converted into hydroxylated metabolites. One such metabolite is 6,7,4'-trihydroxyisoflavone (6,7,4'-THIF), which has been the focus of recent studies due to its various health benefits, however, its anti-adipogenic activity has not been investigated. Our objective was to determine the effects of 6,7,4'-THIF on adipogenesis in 3T3-L1 preadipocytes and elucidate the mechanisms of action involved.
    METHODS AND RESULTS:
    Adipogenesis was stimulated in 3T3-L1 preadipocytes. Both 6,7,4'-THIF and daidzein were treated in the presence and absence of mixture of isobutylmethylxanthine, dexamethasone, and insulin (MDI). We observed that 6,7,4'-THIF, but not daidzein, inhibited MDI-induced adipogenesis significantly at 40 and 80 μM, associated with decreased peroxisome proliferator-activated receptor-γ and C/EBP-α protein expression. 6,7,4'-THIF significantly suppressed MDI-induced lipid accumulation in the early stage of adipogenesis, attributable to a suppression of cell proliferation and the induction of cell cycle arrest. We also determined that 6,7,4'-THIF, but not daidzein, attenuated phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. 6,7,4'-THIF was found to inhibit PI3K activity via direct binding in an ATP-competitive manner.
    CONCLUSIONS:
    Our results suggest that 6,7,4'-THIF suppresses adipogenesis in 3T3-L1 preadipocytes by directly targeting PI3K. Soy isoflavones like 6,7,4'-THIF may have potential for development into novel treatment strategies for chronic obesity.
    In vivo:
    Carcinogenesis. 2011 Apr;32(4):629-35. doi: 10.1093/carcin/bgr008. Epub 2011 Jan 21.
    6,7,4'-trihydroxyisoflavone inhibits HCT-116 human colon cancer cell proliferation by targeting CDK1 and CDK2.[Pubmed: 21258042]
    Colon cancer is a common epithelial malignancies worldwide. Epidemiologic evidence has shown that nutrition and dietary components are important environmental factors involved in the development of this disease.
    METHODS AND RESULTS:
    We investigated the biological activity of 6,7,4'-trihydroxyisoflavone (6,7,4'-THIF, a metabolite of daidzein) in in vitro and in vivo models of human colon cancer. 6,7,4'-THIF suppressed anchorage-dependent and -independent growth of HCT-116 and DLD1 human colon cancer cells more effectively than daidzein. In addition, 6,7,4'-THIF induced cell cycle arrest at the S and G2/M phases in HCT-116 human colon cancer cells. Western blot analysis revealed that 6,7,4'-THIF effectively suppressed the expression of cyclin-dependent kinase (CDK) 2, but had no effect on other S- or G2/M-phase regulatory proteins such as cyclin A, cyclin B1 or CDK1. Daidzein did not affect the expression of any of these proteins. In kinase and pull-down assays, 6,7,4'-THIF, but not daidzein, inhibited CDK1 and CDK2 activities in HCT-116 cells by directly interacting with CDK1 and CDK2. In a xenograft mouse model, 6,7,4'-THIF significantly decreased tumor growth, volume and weight of HCT-116 xenografts. 6,7,4'-THIF bound directly to CDK1 and CDK2 in vivo, resulting in the suppression of CDK1 and CDK2 activity in tumors corresponding with our in vitro results.
    CONCLUSIONS:
    Collectively, these results suggest that CDK1 and CDK2 are potential molecular targets of 6,7,4'-THIF to suppress HCT-116 cell proliferation in vitro and in vivo. These findings provide insight into the biological actions of 6,7,4'-THIF and might establish a molecular basis for the development of new cancer therapeutic agents.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.701 mL 18.5048 mL 37.0096 mL 74.0192 mL 92.5241 mL
    5 mM 0.7402 mL 3.701 mL 7.4019 mL 14.8038 mL 18.5048 mL
    10 mM 0.3701 mL 1.8505 mL 3.701 mL 7.4019 mL 9.2524 mL
    50 mM 0.074 mL 0.3701 mL 0.7402 mL 1.4804 mL 1.8505 mL
    100 mM 0.037 mL 0.185 mL 0.3701 mL 0.7402 mL 0.9252 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    16-Hydroxycleroda-3,13-dien-15,16-olide; 16-Hydroxycleroda-3,13-dien-15,16-olide CFN89213 141979-19-3 C20H30O3 = 318.45 5mg QQ客服:1413575084
    Lancifodilactone C; Lancifodilactone C CFN93271 663176-26-9 C29H36O10 = 544.59 5mg QQ客服:2932563308
    Mdivi-1; Mdivi-1 CFN60325 338967-87-6 C15H10Cl2N2O2S = 353.22 5mg QQ客服:1148253675
    Tubacin; Tubacin CFN60354 537049-40-4 C41H43N3O7S = 721.86 5mg QQ客服:215959384

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