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  • 灵芝酸S

    Ganoderic acid S

    灵芝酸S
    产品编号 CFN99066
    CAS编号 104759-35-5
    分子式 = 分子量 C30H44O3 = 452.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝酸S CFN99066 104759-35-5 1mg QQ客服:3257982914
    灵芝酸S CFN99066 104759-35-5 5mg QQ客服:3257982914
    灵芝酸S CFN99066 104759-35-5 10mg QQ客服:3257982914
    灵芝酸S CFN99066 104759-35-5 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Dicle (Turkey)
  • Universidad Industrial de Santander (Colombia)
  • National Cancer Institute (USA)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Stanford University (USA)
  • Kazusa DNA Research Institute (Japan)
  • Subang Jaya Medical Centre (Malaysia)
  • Medical University of South Carolina (USA)
  • Rio de Janeiro State University (Brazil)
  • University Medical Center Mainz (Germany)
  • University of Madras (India)
  • University of Brasilia (Brazil)
  • University of Vigo (Spain)
  • University of Helsinki (Finland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Journal of Phytopathology2021, 169,Issue11-12.
  • Molecules.2023, 28(7):3039.
  • Jour. of Stored Pro & Postharvest Res.2016, 7(3):32-36
  • Inflammation.2021, doi: 10.1007
  • J Sep Sci.2018, 41(7):1682-1690
  • Food Chem.2018, 252:207-214
  • Talanta.2022, 249:123645.
  • Molecules.2021, 26(9):2802.
  • J Phys Chem Lett.2021, 12(7):1793-1802.
  • Int J Mol Sci.2017, 18(5)
  • Int J Mol Sci.2021, 22(17):9400.
  • Int J Mol Sci.2021, 22(16):8604.
  • Int J Mol Sci.2021, 22(9):5012.
  • Biomedicines.2022, 10(3):583.
  • Biomed Chromatogr.2019, 8:e4774
  • Antioxidants (Basel).2021, 10(9):1487.
  • Biocell2023, 47(8):1793-1802
  • Anat Rec2018, 24264
  • Applied Biological Chemistry2022, 65(12)
  • Molecules.2020, 25(9):2081.
  • Metab Eng.2022, 75:143-152.
  • Mol Med Rep.2014, 9(5):1653-9
  • Biomolecules2021, 11(10),1513.
  • ...
  • 生物活性
    Description: A novel combination of triterpenoids includes at least ganoderic acid S (GAS), ganoderic acid T (GAT), ganoderic acid Me (GAMe), ganoderic acid R (GAR), and ganodermic acid S (GMAS), the composition is suitable for the treatment or prophylaxis of colon cancer, hepatic cancer, breast cancer, lung cancer or leukemia. Ganoderic acid S and Mf induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells.
    In vitro:
    US20140294753[P]. 2014.
    Therapeutic Composition for Treating Cancers.[Reference: WebLink]
    Disclosed herein is a composition that includes a novel combination of triterpenoids for the treatment or prophylaxis of a cancer. The triterpenoids includes at least ganoderic acid S (GAS), ganoderic acid T (GAT), ganoderic acid Me (GAMe), ganoderic acid R (GAR), and ganodermic acid S (GMAS). The composition is suitable for the treatment or prophylaxis of colon cancer, hepatic cancer, breast cancer, lung cancer or leukemia.
    Phytomedicine. 2011 Mar 15;18(5):349-55.
    Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells.[Pubmed: 21036023 ]

    METHODS AND RESULTS:
    In this work, the effects of a pair of positional isomer of ganoderic acids (GAs), namely ganoderic acid Mf (GA-Mf) and Ganoderic acid S (GA-S) purified from the fermented mycelia of Ganoderma lucidum, on induction of cell apoptosis and the apoptotic pathway in HeLa cells were investigated. The results demonstrate that both isomers decreased cell population growth on various human carcinoma cell lines by MTT assay, while GA-Mf had better selectivity between normal and cancer cells. The flow cytometry analysis indicated that treatment of HeLa cells with GA-S caused cell cycle arrest in the S phase, while GA-Mf caused cell cycle arrest in the G1 phase. Compared with GA-S, GA-Mf had more potent increase in the number of early and late apoptotic cells. Treatment of HeLa cells with each isomer decreased the mitochondria membrane potential and caused the release of cytochrome c from mitochondria into the cytosol. In addition, stimulation of caspase-3 and caspase-9 activity was observed. The Bax/Bcl-2 ratio was also increased in GA-treated HeLa cells. The results demonstrated that both isomers GA-Mf and GA-S induced apoptosis of human HeLa cells through a mitochondria mediated pathway, but they had the different cell cycle arrest specificity.
    CONCLUSIONS:
    The findings will be helpful to the development of useful cancer chemopreventive compounds from G. lucidum.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.209 mL 11.0448 mL 22.0897 mL 44.1794 mL 55.2242 mL
    5 mM 0.4418 mL 2.209 mL 4.4179 mL 8.8359 mL 11.0448 mL
    10 mM 0.2209 mL 1.1045 mL 2.209 mL 4.4179 mL 5.5224 mL
    50 mM 0.0442 mL 0.2209 mL 0.4418 mL 0.8836 mL 1.1045 mL
    100 mM 0.0221 mL 0.1104 mL 0.2209 mL 0.4418 mL 0.5522 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    23S-羟基-11,15-二氧-灵芝酸DM; 23S-hydroxy-11,15-dioxo-ganoderic acid DM CFN80433 1085273-49-9 C30H40O7 = 512.63 5mg QQ客服:215959384
    新化合物19; New compound 19 CFN95538 N/A C32H42O8 = 554.7 5mg QQ客服:1413575084
    灵芝酸GS-3; Ganoderic acid GS-3 CFN95518 1206781-66-9 C32H46O8 = 558.7 5mg QQ客服:1457312923
    Resinacein D; Resinacein D CFN95591 2231061-47-3 C30H46O5 = 486.7 5mg QQ客服:1413575084
    11alpha-hydroxy-3,7-dioxo-5alpha-lanosta-8,24(E)-dien-26-oic acid; 11alpha-hydroxy-3,7-dioxo-5alpha-lanosta-8,24(E)-dien-26-oic acid CFN95592 1245703-70-1 C30H44O5 = 484.7 5mg QQ客服:1457312923
    丹芝酸E; Ganolucidic acid E CFN95536 114567-50-9 C30H44O5 = 484.7 5mg QQ客服:2056216494
    新化合物22; New compound 22 CFN95570 N/A C30H44O6 = 500.7 5mg QQ客服:3257982914
    灵芝酸beta; Ganoderic acid beta CFN95537 217476-76-1 C30H44O6 = 500.7 5mg QQ客服:3257982914
    灵芝酸GS-1; Ganoderic acid GS-1 CFN95571 1206781-64-7 C30H42O6 = 498.7 5mg QQ客服:3257982914
    灵芝酸GS-3; Ganoderic acid GS-2 CFN95549 1206781-65-8 C30H44O6 = 500.7 5mg QQ客服:1457312923

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