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  • 灵芝酸T-Q

    Ganoderic acid T-Q

    灵芝酸T-Q
    产品编号 CFN92237
    CAS编号 112430-66-7
    分子式 = 分子量 C32H46O5 = 510.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝酸T-Q CFN92237 112430-66-7 1mg QQ客服:3257982914
    灵芝酸T-Q CFN92237 112430-66-7 5mg QQ客服:3257982914
    灵芝酸T-Q CFN92237 112430-66-7 10mg QQ客服:3257982914
    灵芝酸T-Q CFN92237 112430-66-7 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Martin Luther University of Halle-Wittenberg (Germany)
  • Tohoku University (Japan)
  • Max-Planck-Insitut (Germany)
  • Sapienza University of Rome (Italy)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Lodz University of Technology (Poland)
  • National Cancer Center Research Institute (Japan)
  • Shanghai University of TCM (China)
  • University of Helsinki (Finland)
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  • Centralised Purchases Unit (CPU), B.I.T.S (India)
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  • The University of Newcastle (Australia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Planta Med.2023, a-2192-2281.
  • Int Immunopharmacol.2019, 71:22-31
  • J Agric Food Chem.2022, 70(51):16176-16187.
  • Braz J Med Biol Res.2021, 54(12):e11183.
  • Pamukkale Medical Journal2022, 15(4):796-803.
  • Metab Eng.2022, 75:143-152.
  • Antioxidants (Basel).2021, 10(11): 1802.
  • Antioxidants.2022, 11(4), 67.
  • Exp Parasitol.2017, 183:160-166
  • The Korea Society of Pha.2014, 300-314
  • Front Microbiol.2022, 12:833233.
  • Anat Rec (Hoboken).2021, 304(2):323-332.
  • Chem Biol Interact.2016, 260:168-175
  • Int J Mol Sci.2022, 23(20):12516.
  • Pharmaceuticals (Basel).2024, 17(3):352.
  • Tumour Biol.2015, 36(9):7027-34
  • Cancer Sci.2022, 113(4):1406-1416.
  • Pharmaceutics.2021, 13(7):1028.
  • Curr Issues Mol Biol.2023, 45(3):2136-2156.
  • Front. Pharmacol.2022, 901563.
  • Toxicol Appl Pharmacol.2022, 434:115815.
  • Phytochem Anal.2016, 27(5):296-303
  • Molecules.2019, 24(6):E1177
  • ...
  • 生物活性
    Description: Ganoderic acid T-Q and TR are two inhibitors of H5N1 and H1N1 NAs.
    Targets: H5N1 | H1N1
    In vitro:
    Scientific Reports, 2015, 5:13194.
    Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design.[Reference: WebLink]
    Neuraminidase (NA) inhibitors are the dominant antiviral drugs for treating influenza in the clinic. Increasing prevalence of drug resistance makes the discovery of new NA inhibitors a high priority.
    METHODS AND RESULTS:
    Thirty-one triterpenoids from the medicinal mushroom Ganoderma lingzhi were analyzed in an in vitro NA inhibition assay, leading to the discovery of ganoderic acid T-Q and TR as two inhibitors of H5N1 and H1N1 NAs. Structure-activity relationship studies revealed that the corresponding triterpenoid structure is a potential scaffold for the design of NA inhibitors. Using these triterpenoids as probes we found, through further in silico docking and interaction analysis, that interactions with the amino-acid residues Arg292 and/or Glu119 of NA are critical for the inhibition of H5N1 and H1N1.
    CONCLUSIONS:
    These findings should prove valuable for the design and development of NA inhibitors.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9581 mL 9.7905 mL 19.581 mL 39.1619 mL 48.9524 mL
    5 mM 0.3916 mL 1.9581 mL 3.9162 mL 7.8324 mL 9.7905 mL
    10 mM 0.1958 mL 0.979 mL 1.9581 mL 3.9162 mL 4.8952 mL
    50 mM 0.0392 mL 0.1958 mL 0.3916 mL 0.7832 mL 0.979 mL
    100 mM 0.0196 mL 0.0979 mL 0.1958 mL 0.3916 mL 0.4895 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    灵芝酸S; Ganoderic acid S CFN99066 104759-35-5 C30H44O3 = 452.7 5mg QQ客服:1413575084
    灵芝酸TN; Ganoderic acid TN CFN90298 112430-64-5 C32H48O5 = 512.73 5mg QQ客服:1457312923
    灵芝酸X; Ganoderic acid X CFN92996 86377-53-9 C32H48O5 = 512.72 5mg QQ客服:1457312923
    灵芝酸Jb; Ganoderic acid Jb CFN92997 112430-68-9 C30H46O4 = 470.68 5mg QQ客服:1413575084
    灵芝酸TR; Ganoderic acid TR CFN92235 862893-75-2 C30H44O4 = 468.7 5mg QQ客服:3257982914
    灵芝酸T-Q; Ganoderic acid T-Q CFN92237 112430-66-7 C32H46O5 = 510.7 5 mg QQ客服:2056216494
    胭脂虫酸; Coccinic acid CFN99083 107783-45-9 C30H46O3 = 454.7 5mg QQ客服:2159513211
    安五酸; Anwuweizonic acid CFN92727 117020-59-4 C30H46O3 = 454.7 5mg QQ客服:1457312923
    7-氧代-灵芝酸Z; 7-Oxo-ganoderic acid Z CFN92998 929248-72-6 C30H46O4 = 470.68 5mg QQ客服:3257982914
    灵芝酸DM; Ganoderic acid DM CFN99815 173075-45-1 C30H44O4 = 468.7 5mg QQ客服:2159513211

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