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  • 中药标准品生产商,产品定制服务
  • 二氢大豆苷元


    产品编号 CFN90686
    CAS编号 17238-05-0
    分子式 = 分子量 C15H12O4 = 256.26
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The seeds of Glycine max.
    产品名称 产品编号 CAS编号 包装 QQ客服
    二氢大豆苷元 CFN90686 17238-05-0 1mg QQ客服:1457312923
    二氢大豆苷元 CFN90686 17238-05-0 5mg QQ客服:1457312923
    二氢大豆苷元 CFN90686 17238-05-0 10mg QQ客服:1457312923
    二氢大豆苷元 CFN90686 17238-05-0 20mg QQ客服:1457312923
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

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    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • Universidad de Buenos Aires (Argentina)
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  • Universidad Veracuzana (Mexico)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Ain Shams University (Egypt)
  • University of Pretoria (South Africa)
  • Warszawski Uniwersytet Medyczny (Poland)
  • University of Liège (Belgium)
  • Melbourne University (Australia)
  • Mahidol University (Thailand)
  • University of Leipzig (Germany)
  • Copenhagen University (Denmark)
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  • ...
  • 生物活性
    Description: Dihydrodaidzein-producing bacteria might lead to clarification of some of the mechanisms regulating the production of equol by fecal microbiota.
    Targets: P-gp
    In vitro:
    Biosci Microflora. 2011;30(3):65-71.
    Dihydrodaidzein-producing Clostridium-like intestinal bacterium, strain TM-40, affects in vitro metabolism of daidzein by fecal microbiota of human male equol producer and non-producers.[Pubmed: 25045313]
    Much attention has been focused on the biological effects of equol, a metabolite of daidzein produced by intestinal microbiota. However, little is known about the role of isoflavone metabolizing bacteria in the intestinal microbiota.
    Recently, we isolated a dihydrodaidzein (DHD)-producing Clostridium-like bacterium, strain TM-40, from human feces. We investigated the effects of strain TM-40 on in vitro daidzein metabolism by human fecal microbiota from a male equol producer and two male equol non-producers. In the fecal suspension from the male equol non-producer and DHD producer, DHD was detected in the in vitro fecal incubation of daidzein after addition of TM-40. The DHD concentration increased as the concentration of strain TM-40 increased. In the fecal suspension from the equol producer, the fecal equol production was increased by the addition of strain TM-40. The occupation ratios of Bifidobacterium and Lactobacillales were higher in the equol non-producers than in the equol producer. Adding isoflavone-metabolizing bacteria to the fecal microbiota should facilitate the estimation of the metabolism of isoflavonoids by fecal microbiota.
    Studies on the interactions among equol-producing microbiota and DHD-producing bacteria might lead to clarification of some of the mechanisms regulating the production of equol by fecal microbiota.
    Biosci Biotechnol Biochem. 2013;77(11):2210-7.
    Transport mechanisms for soy isoflavones and microbial metabolites dihydrogenistein and dihydrodaidzein across monolayers and membranes.[Pubmed: 24200780]
    Isoflavone data concerning the metabolism and permeability on intestinal epithelial cells are scarce, particularly for microbial isoflavone metabolites.
    This study evaluates the absorption mechanisms for the isoflavones, genistein and daidzein, and their microbial metabolites, dihydrogenistein (DHG) and dihydrodaidzein (DHD). The permeability characteristics of isoflavones were compared by using the Caco-2 human colon adenocarcinoma cell line for a parallel artificial membrane permeability assay, and comparing their physicochemical properties.
    The data suggest that genistein, DHG and DHD were efficiently transported by passive diffusion according to the pH-partition hypothesis. Genistein was conjugated by phase II metabolizing enzymes and acted as a substrate of the breast cancer resistance protein (BCRP). Daidzein was not conjugated but did act as a substrate for BCRP, multidrug resistance-associated proteins, and P-glycoprotein. In contrast, DHG and DHD were markedly more permeable than their parent isoflavones; they were therefore difficult to transport by the efflux effect, and glucuronidation/sulfation was limited by the flux time.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.9023 mL 19.5114 mL 39.0229 mL 78.0457 mL 97.5572 mL
    5 mM 0.7805 mL 3.9023 mL 7.8046 mL 15.6091 mL 19.5114 mL
    10 mM 0.3902 mL 1.9511 mL 3.9023 mL 7.8046 mL 9.7557 mL
    50 mM 0.078 mL 0.3902 mL 0.7805 mL 1.5609 mL 1.9511 mL
    100 mM 0.039 mL 0.1951 mL 0.3902 mL 0.7805 mL 0.9756 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    甘草宁 G; Gancaonin G CFN96524 126716-34-5 C21H20O5 = 352.39 5mg QQ客服:1413575084
    刺桐素 G; Erythrinin G CFN96545 1616592-61-0 C20H18O6 = 354.35 5mg QQ客服:215959384
    刺桐素 F; Erythrinin F CFN96549 1616592-60-9 C20H18O7 = 370.35 5mg QQ客服:1413575084
    刺桐素 D; Erythrinin D CFN96546 1616592-59-6 C21H18O6 = 366.37 5mg QQ客服:2159513211
    异补骨脂香豆素A; Isoficusin A CFN96554 1914963-20-4 C25H24O5 = 404.47 5mg QQ客服:215959384
    5-甲基-7-甲氧基异黄酮; 5-Methyl-7-methoxyisoflavone CFN93022 82517-12-2 C17H14O3 = 266.29 5mg QQ客服:3257982914
    紫黄檀素; Violanone CFN95385 52250-38-1 C17H16O6 = 316.3 10mg QQ客服:1457312923
    3'-O-甲基紫黄檀素; 3'-O-Methylviolanone CFN95387 56973-42-3 C18H18O6 = 330.3 5mg QQ客服:2056216494
    二氢大豆苷元; Dihydrodaidzein CFN90686 17238-05-0 C15H12O4 = 256.26 10mg QQ客服:1413575084
    大豆苷元; Daidzein CFN98774 486-66-8 C15H10O4 = 254.2 20mg QQ客服:215959384





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