Info: Read More
  • 中药标准品生产商,产品定制服务
  • 异刺芒柄花素

    Isoformononetin

    异刺芒柄花素
    产品编号 CFN95024
    CAS编号 486-63-5
    分子式 = 分子量 C16H12O4 = 268.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The stem barks of Butea monosperma
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异刺芒柄花素 CFN95024 486-63-5 1mg QQ客服:3257982914
    异刺芒柄花素 CFN95024 486-63-5 5mg QQ客服:3257982914
    异刺芒柄花素 CFN95024 486-63-5 10mg QQ客服:3257982914
    异刺芒柄花素 CFN95024 486-63-5 20mg QQ客服:3257982914
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Helmholtz Zentrum München (Germany)
  • Kyung Hee University (Korea)
  • Vin?a Institute of Nuclear Sciences (Serbia)
  • Universidad de Buenos Aires (Argentina)
  • Warszawski Uniwersytet Medyczny (Poland)
  • University of Wollongong (Australia)
  • Universit?t Basel (Switzerland)
  • Hamdard University (India)
  • Ain Shams University (Egypt)
  • St. Jude Children Research Hospital (USA)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • University of Pretoria (South Africa)
  • Auburn University (USA)
  • Imperial College London (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • United States Patent Application2020, 20200038363
  • J Microbiol Biotechnol.2020, 30(2):178-186.
  • J Sci Food Agric.2023, 103(1):213-220.
  • Korean Journal of Pharmacognosy2019, 50(4):285-290
  • Sci Rep.2017, 7:46299
  • Pharmaceuticals (Basel).2020, 13(9):262.
  • Cancer Sci.2022, 113(4):1406-1416.
  • Jour. of Stored Pro & Postharvest Res.2016, 7(3):32-36
  • FASEB J.2019, 33(2):2026-2036
  • Food Funct.2022, D1FO03838A.
  • Antiviral Res.2013, 98(3):386-93
  • Universitat Stuttgart2022, opus-12200.
  • J Am Soc Mass Spectrom.2021, 32(5):1205-1214.
  • J of l. Chroma.&Related Tech2020, 43(11-12):414-423.
  • Life Sci.2022, 298:120488.
  • J Agric Food Chem.2021, 69(11):3496-3510.
  • Int J Mol Sci.2022, 23(23):14545.
  • Journal of Functional Foods2022, 96: 105216.
  • Molecules.2017, 22(12)
  • Anal Bioanal Chem.2020, 412(12):3005-3015.
  • Int J Mol Sci.2022, 23(20):12516.
  • Naunyn Schmiedebergs Arch Pharmacol.2021, 394(1):107-115.
  • Front Pharmacol.2019, 10:1226
  • ...
  • 生物活性
    Description: Isoformononetin shows fungitoxic activity against Cladosporium sphaerospermum; it also has immunomodulatory activity, it inhibits the differentiation of Th17 cells and B-cell lymphopoesis to promote osteogenesis in estrogen-deficient bone loss conditions. Isoformononetin reverses bone loss in osteopenic rats and exerts bone anabolic action by preventing osteoblast apoptosis.
    Targets: IL Receptor | Antifection
    In vitro:
    J Asian Nat Prod Res. 2013;15(1):71-7.
    Chemical constituents of Arisaema franchetianum tubers.[Pubmed: 23106482]

    METHODS AND RESULTS:
    A novel pyrrolidine alkaloid, (2R*,3S*,5S*)-N,2-dimethyl-3-hydroxy-5-(10-phenyldecyl)pyrrolidine (1), and 17 known compounds were isolated from Arisaema franchetianum Engl. (Araceae) tubers. The 17 compounds were bergenin (2), emodin (3), caffeic acid (4), nobiletin (5), 3-O-β-d-galactopyranosyl-hederagenin 28-O-β-d-xylopyranosyl(1 → 6)-β-d-galactopyranosyl ester (6), coniferin (7), qingyangshengenin (8), methylconiferin (9), syringaresinol 4'-O-β-d-glucopyranoside (10), gagaminine (11), perlolyrine (12), (S)-1-(1'-hydroxyethyl)-β-carboline (13), 1-(β-carboline-1-yl)-3,4,5-trihydroxy-1-pentanone (14), 1-methoxycarbonyl-β-carboline (15), indolo[2,3-α]carbazole (16), 4-hydroxycinnamic acid methyl ester (17), and methyl 4-[2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-1-(hydroxymethyl)ethyl] ferulate (18).
    CONCLUSIONS:
    The inhibitory activities of compound 1 and its N-methyl derivative (1a) against porcine respiratory and reproductive syndrome virus (PRRSV), human leukemic K562 cells, and human breast cancer MCF-7 cells were evaluated. Compounds 1 [50% inhibited concentration (IC(50)) = 12.5 ± 0.6 μM] and 1a (IC(50) = 15.7 ± 0.9 μM) were cytotoxic against K562 cells. Compound 1a also had a weak effect on PRRSV with an IC(50) value of 31.9 ± 6.0 μM [selectivity index (SI) = 18.7].
    J Agric Food Chem. 2000 Aug;48(8):3662-5.
    Effect of spores of saprophytic fungi on phytoalexin accumulation in seeds of frog-eye leaf spot and stem canker-resistant and -susceptible soybean (Glycine max L.) cultivars.[Pubmed: 10956166]

    METHODS AND RESULTS:
    Two saprophytic fungi (Mucor ramosissimus and Rhizopus sp.) were tested for their ability to induce phytoalexin production by seeds of frog-eye leaf spot and stem canker-resistant and -susceptible soybean (Glycine max L.) cultivars. Only M. ramosissimus was shown to elicit a response and qualitative differences in phytoalexin accumulation were found between the susceptible and resistant cultivars. Glyceollins I, II, and III and glycinol were isolated from the susceptible cultivar, whereas Glyceollins I, II, and III, glycinol, glyceocarpin, genistein, isoformononetin, and N-acetyltyramine accumulated in the resistant cultivar in response to the same fungal elicitor. Genistein was found to be an inducibly formed isoflavonoid instead of a constitutive metabolite in the resistant cultivar, whereas N-acetyltyramine is described for the first time as a soybean phytoalexin.
    CONCLUSIONS:
    All the compounds, except genistein, showed fungitoxic activity against Cladosporium sphaerospermum. Spectral data of the pterocarpan phytoalexins, genistein, and N-acetyltyramine are also given in this work.
    In vivo:
    Menopause. 2016 May;23(5):565-76.
    Methoxyisoflavones formononetin and isoformononetin inhibit the differentiation of Th17 cells and B-cell lymphopoesis to promote osteogenesis in estrogen-deficient bone loss conditions.[Pubmed: 27070807 ]
    Recent studies have shown that immune system plays a major role in pathophysiology of postmenopausal osteoporosis. Previously we have shown that phytoestrogens like daidzein and medicarpin exhibit immunoprotective effects, by virtue of which they alleviate bone loss. With this background, methoxyisoflavones like formononetin (formo) and Isoformononetin (isoformo) that have been studied for preventing bone loss in ovariectomized rats were tested for their immunomodulatory effects in estrogen-deficient bone loss mice model.
    METHODS AND RESULTS:
    Adult Balb/c mice (N = 8/group) were given oral dose of formo and isoformo at 10 mg/kg body weight, post ovariectomy (Ovx) daily for 6 weeks. Animals were autopsied and long bones were harvested to study bone microarchitecture. Peripheral blood mononuclear cells were isolated for fluorescence-activated cell sorting and RNA analysis. Serum was collected for enzyme-linked immunosorbent assay. It was observed that formo and isoformo treatment to Ovx mice led to significant restoration of Ovx-induced deterioration of trabecular microarchitecture. Pro-osteoclastogenic subset Th17 and B cells were decreased in formo/isoformo-treated Ovx mice in comparison with vehicle-treated Ovx group. Formo and isoformo treatment to Ovx mice also led to decreased expression of Th17 diffentiation factors and promoted T-regulatory cell differentiation. Formo was more effective in enhancing the FOXP3 expression compared with isoformo. IL-17A-induced osteoclastogenesis and inhibition of osteoblast apoptosis were also suppressed by formo and isoformo treatment, with formo having a more potent effect.
    CONCLUSIONS:
    Our study demonstrates the immunomodulatory activity of methoxyisoflavones, formo, and isoformo, which translate into improved skeletal parameters, thereby preventing Ovx-induced bone loss.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.7272 mL 18.6359 mL 37.2717 mL 74.5434 mL 93.1793 mL
    5 mM 0.7454 mL 3.7272 mL 7.4543 mL 14.9087 mL 18.6359 mL
    10 mM 0.3727 mL 1.8636 mL 3.7272 mL 7.4543 mL 9.3179 mL
    50 mM 0.0745 mL 0.3727 mL 0.7454 mL 1.4909 mL 1.8636 mL
    100 mM 0.0373 mL 0.1864 mL 0.3727 mL 0.7454 mL 0.9318 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异刺芒柄花素; Isoformononetin CFN95024 486-63-5 C16H12O4 = 268.3 5mg QQ客服:2056216494
    大豆苷元甲醚; Daidzein dimethyl ether CFN90873 1157-39-7 C17H14O4 = 282.3 20mg QQ客服:3257982914
    染料木素; Genistein CFN98681 446-72-0 C15H10O5 = 270.2 20mg QQ客服:2159513211
    5-O-Methylgenistein; 5-O-Methylgenistein CFN89437 4569-98-6 C16H12O5 = 284.26 5mg QQ客服:1413575084
    鹰嘴豆芽素A; Biochanin A CFN99734 491-80-5 C16H12O5 = 284.26 20mg QQ客服:215959384
    4’7-二甲氧基-5-羟基异黄酮; 7-O-Methylbiochanin A CFN91010 34086-51-6 C17H14O5 = 298.3 10mg QQ客服:2056216494
    樱黄素; Prunetin CFN90189 552-59-0 C16H12O5 = 284.26 20mg QQ客服:1413575084
    6-Methylgenistein; 6-Methylgenistein CFN96540 97575-49-0 C16H12O5 = 284.26 5mg QQ客服:2159513211
    6,7,4'-三羟基异黄酮; 6,7,4'-Trihydroxyisoflavone CFN90796 17817-31-1 C15H10O5 = 270.2 5mg QQ客服:1413575084
    黄豆黄素; Glycitein CFN99106 40957-83-3 C16H12O5 = 284.26 20mg QQ客服:1413575084

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产