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  • 葛根素-6''-O-木糖苷

    Puerarin 6''-O-xyloside

    葛根素-6''-O-木糖苷
    产品编号 CFN90640
    CAS编号 114240-18-5
    分子式 = 分子量 C26H28O13 = 548.49
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Pueraria lobata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    葛根素-6''-O-木糖苷 CFN90640 114240-18-5 10mg QQ客服:215959384
    葛根素-6''-O-木糖苷 CFN90640 114240-18-5 20mg QQ客服:215959384
    葛根素-6''-O-木糖苷 CFN90640 114240-18-5 50mg QQ客服:215959384
    葛根素-6''-O-木糖苷 CFN90640 114240-18-5 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Cincinnati (USA)
  • Aarhus University (Denmark)
  • Indian Institute of Science (India)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Sanford Burnham Medical Research Institute (USA)
  • Mendel University in Brno (Czech Republic)
  • University of Wollongong (Australia)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • University of Toronto (Canada)
  • Kamphaengphet Rajabhat University (Thailand)
  • Georgia Institute of Technology (USA)
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  • Universidad Veracuzana (Mexico)
  • Chungnam National University (Korea)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antiviral Res.2013, 98(3):386-93
  • J Breast Cancer.2015, 18(2):112-118
  • Molecules.2015, 20(10):19172-88
  • Oncotarget.2015, 6(31):30831-49
  • Universite de Bordeaux2017, 2017BORD0867
  • J Ethnopharmacol.2017, 209:305-316
  • Front Plant Sci.2017, 8:723
  • Int J Mol Sci.2018, 19(9):E2825
  • Korean J. Medicinal Crop Sci.2018, 26(2):148-156
  • Oncology Letters2018, 4690-4696
  • Biochem Biophys Res Commun.2018, 505(1):261-266
  • Int J Mol Sci.2019, 20(11):E2734
  • Int J Mol Sci.2019, 20(8):E1855
  • Molecules.2019, 24(1):E159
  • Molecules.2019, 24(11):E2102
  • Chem Biol Interact.2019, 315:108910
  • Aquaculture2019, 510:392-399
  • Journal of Functional Foods2019, 52:430-441
  • Anal Biochem.2019, 569:10-15
  • Pharmacol Rep.2019, 71(2):289-298
  • Process Biochemistry2019, 87:213-220
  • Psychopharmacology (Berl).2020, 10.1007
  • Saudi Pharm J2020, 10.1016
  • ...
  • 生物活性
    Description: Puerarin 6''-O-xyloside possesses significant anti-osteoporotic activity on ovariectomy mice, it has significant antitumour activities, the mechanisms are related to increased levels of caspase-3, caspase-7, caspase-9 and Bax, and reduced levels Bcl-2.
    Targets: Bcl-2/Bax | Caspase
    In vitro:
    Pharm Biol. 2016 Sep;54(9):1793-9.
    In vitro and in vivo antitumour activities of puerarin 6″-O-xyloside on human lung carcinoma A549 cell line via the induction of the mitochondria-mediated apoptosis pathway.[Pubmed: 26730946]
    Pueraria lobata (Leguminoseae) shows cytotoxic effects against cancer cells; however, its active components remain unclear. This study investigated the antitumour activity of puerarin 6″-O-xyloside (POS) on the human lung carcinoma A549 cell line.
    METHODS AND RESULTS:
    The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to determine the cytotoxicity of POS (at 10, 20 and 40 μM) in vitro, and xenograft nude mice were established to evaluate the antitumour effect of POS (at 40 mg/kg/d) in vivo by 15 days intraperitoneal injection (ip). To explore its mechanism of action, flow cytometry was performed to determine the pro-apoptotic effect of POS (at 10, 20 and 40 μM). Subsequently, the expression of caspase-3, caspase-7, caspase-9, Bcl-2 and Bax in A549 cells were determined. POS showed significant cytotoxicity toward A549 cells (p < 0.05) by inducing apoptosis. Treatment with POS significantly upregulated the levels of caspase-3 (p < 0.01), caspase-7 (p < 0.01), caspase-9 (p < 0.01) and Bax (p < 0.01) in A549 cells, and Bcl-2 was downregulated (p < 0.01). Additionally, the in vivo animal study showed that POS significantly inhibited tumour growth in A549 cells (p < 0.01).
    CONCLUSIONS:
    Our study demonstrated the POS has significant antitumour activities. The mechanisms are related to increased levels of caspase-3, caspase-7, caspase-9 and Bax, and reduced levels Bcl-2.
    In vivo:
    Pharm Biol. 2015 Apr 10:1-7.
    Anti-osteoporotic activity of puerarin 6″-O-xyloside on ovariectomized mice and its potential mechanism.[Pubmed: 25857587]
    Osteoporosis is one of the most common bone diseases, and radix of Pueraria lobata (Willd.) Ohwi possesses an obvious therapeutical effect on postmenopausal osteoporosis. This study investigates the anti-osteoporotic activity of the puerarin 6"-O-xyloside (PXY) on ovariectomized mice and its related mechanism.
    METHODS AND RESULTS:
    Osteoporotic mice model was established by ovariectomy (OVX). A total of 50 mice were divided into five groups (n = 10): sham, OVX group, PXY treatment groups (20, 40, and 60 mg/kg/d, i.p.). After 12 weeks' treatment, body weights were recorded. Then, mice were sacrificed, and serum samples were collected to determine the blood calcium, blood phosphorus, alkaline phosphatase (ALP), and osteoprotegerin (OPG) concentrations and uterine index was assayed. The thigh-bones of mice were collected to evaluate histopathological changes. In the in vitro experiment, the effect of PXY on osteoblasts' proliferation was evaluated and western blotting was performed to determine expressions of OPG and the receptor activators of NF-κB ligand (RANKL), as well as the ratio of OPG/RANKL. PXY (40 and 60 mg/kg/d, i.p.) obviously decreased body weights and increased uterine index of OVX (p < 0.05), and improved osteoporotic syndromes of OVX mice; PXY also significantly increased the concentrations of blood calcium, blood phosphorus, ALP, and OPG of OVX mice (p < 0.05); moreover, PXY obviously up-regulated the ratio of OPG/RANKL (p < 0.05).
    CONCLUSIONS:
    Our results demonstrated that the puerarin 6"-O-xyloside possesses significant anti-osteoporotic activity on ovariectomy mice.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8232 mL 9.1159 mL 18.2319 mL 36.4637 mL 45.5797 mL
    5 mM 0.3646 mL 1.8232 mL 3.6464 mL 7.2927 mL 9.1159 mL
    10 mM 0.1823 mL 0.9116 mL 1.8232 mL 3.6464 mL 4.558 mL
    50 mM 0.0365 mL 0.1823 mL 0.3646 mL 0.7293 mL 0.9116 mL
    100 mM 0.0182 mL 0.0912 mL 0.1823 mL 0.3646 mL 0.4558 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3'-羟基葛根素芹菜糖苷; 3'-Hydroxymirificin CFN95102 168035-02-7 C26H28O14 = 564.5 5mg QQ客服:2159513211
    3'-甲氧基葛根素芹菜糖苷; 3'-Methoxymirificin CFN95112 1297609-29-0 C27H30O14 = 578.5 5mg QQ客服:1148253675
    4'-O-甲氧基葛根素; 4'-Methoxypuerarin CFN90782 92117-94-7 C22H22O9 = 430.4 10mg QQ客服:215959384
    葛根素-6''-O-木糖苷; Puerarin 6''-O-xyloside CFN90640 114240-18-5 C26H28O13 = 548.49 20mg QQ客服:3257982914
    Formononetin-8-C-beta-D-apiofuranosyl-(1→6)-O-beta-D-glucopyranoside; Formononetin-8-C-beta-D-apiofuranosyl-(1->6)-O-beta-D-glucopyranoside CFN95157 1147858-78-3 C27H30O13 = 562.5 10mg QQ客服:1148253675
    美佛辛-4'-O-葡萄糖苷; Mirificin-4'-O-glucoside CFN95091 168035-01-6 C32H38O18 = 710.6 5mg QQ客服:2932563308
    3'-羟基葛根素; 3'-Hydroxy Puerarin CFN90236 117076-54-5 C21H20O10 = 432.38 20mg QQ客服:2932563308
    3'-甲氧基葛根素; 3'-Methoxypuerarin CFN90780 117047-07-1 C22H22O10 = 446.4 20mg QQ客服:1148253675
    大豆苷; Daidzin CFN99101 552-66-9 C21H20O9 = 416.38 20mg QQ客服:2159513211
    大豆苷元-7-O-葡萄糖醛酸苷; Daidzein 7-O-glucuronide CFN70352 38482-80-3 C21H18O10 = 430.4 5mg QQ客服:1413575084

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