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  • Formononetin-8-C-beta-D-apiofuranosyl-(1→6)-O-beta-D-glucopyranoside

    Formononetin-8-C-beta-D-apiofuranosyl-(1->6)-O-beta-D-glucopyranoside

    Formononetin-8-C-beta-D-apiofuranosyl-(1→6)-O-beta-D-glucopyranoside
    产品编号 CFN95157
    CAS编号 1147858-78-3
    分子式 = 分子量 C27H30O13 = 562.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The fruits of Glycine max
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Formononetin-8-C-beta-D-apiofuranosyl-(1→6)-O-beta-D-glucopyranoside CFN95157 1147858-78-3 1mg QQ客服:1413575084
    Formononetin-8-C-beta-D-apiofuranosyl-(1→6)-O-beta-D-glucopyranoside CFN95157 1147858-78-3 5mg QQ客服:1413575084
    Formononetin-8-C-beta-D-apiofuranosyl-(1→6)-O-beta-D-glucopyranoside CFN95157 1147858-78-3 10mg QQ客服:1413575084
    Formononetin-8-C-beta-D-apiofuranosyl-(1→6)-O-beta-D-glucopyranoside CFN95157 1147858-78-3 20mg QQ客服:1413575084
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

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    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
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  • 生物活性
    Description: Reference standards.
    In vitro:
    China journal of Chinese materia medica, 2017, 42(16):3206-3212.
    Absorption and transport of isoflavonoid compounds from Tongmai formula across human intestinal epithelial (Caco-2) cells in vitro.[Pubmed: 29171242]
    Tongmai formula (TMF) is a drug combination of three components including Puerariae Lobatae Radix [roots of Pueraria lobata], Salviae Miltiorrhizae Radix (roots of Salvia miltiorrhiza) and Chuanxiong Rhizoma (rhizomes of Ligusticum chuanxiong) in a weight ratio of 1∶1∶1.
    METHODS AND RESULTS:
    The absorption and transport of isoflavonoid compounds from Tongmai formula across human intestinal epithelial (Caco-2) cells in vitro were studied in this paper. The assay isoflavonoid compounds include daidzein, formononetin, 5-hydroxylononin, ononin, daidzin, 3'-methoxypuerarin, genistin, puerarin, formononetin-8-C-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside(Formononetin-8-C-beta-D-apiofuranosyl-(1->6)-O-beta-D-glucopyranoside), formononetin-7-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside, lanceolarin, kakkanin, daidzein-7,4'-di-O-β-D-glucopyranoside, mirificin, 3'-hydroxypuerarin, 3'-methoxydaidzin, formononetin-8-C-β-D-xylopyranosyl-(1→6)-O-β-D-glucopyranoside, genistein-8-C-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside, genistein-7-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside (ambocin), 3'-hydroxymirificin, 6″-O-β-D-xylosylpuerarin, biochanin A-8-C-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside, 3'-methoxydaidzein-7,4'-di-O-β-D-glucopyranoside, daidzein-7-O-β-D-glucopyranosyl-(1→4)-O-β-D-glucopyranoside, and daidzein-7-O-α-D-glucopyranosyl-(1→4)-O-β-D-glucopyranoside. By using human Caco-2 monolayer as an intestinal epithelial cell model in vitro, the permeability of above-mentioned 25 isoflavonoids in TMF were studied from the apical (AP) side to basolateral (BL) side or from the BL side to AP side. The assay compounds were determined by reversed phased high-performance liquid chromatography (HPLC) coupled with UV detector. Transport parameters and apparent permeability coefficients (Papp) were then calculated and and compared with those of propranolol and atenolol, which are the transcellular transport marker and as a control substance for high and poor permeability, respectively. The Papp values of daidzein and formononetin were (2.55±0.03) ×10⁻⁵,(3.06±0.01) ×10⁻⁵ cm•s⁻¹ from AP side to BL side, respectively, and (2.62±0.00) ×10⁻⁵, (2.65±0.11) ×10⁻⁵ cm•s⁻¹ from BL side to AP side, respectively. Under the condition of this experiment, the Papp value was (2.66±0.32) ×10⁻⁵ cm•s⁻¹ for propranolol and (2.34±0.10) ×10⁻⁷ cm•s⁻¹ for atenolol. The Papp values of daidzein and formononetin were at a same magnitude with those of propranolol. And the Papp values of other 23 isoflavonoid compounds were at a same magnitude with those of atenolol. On the other hand, the rats of Papp AP→BL/Papp BL→AP of daidzein and formononetin on the influx transport were 0.97 and 1.15, respectively. It can be predicted that daidzein and formononetin can be absorbed across intestinal epithelial cells to go to the body circulation by the passive diffusion mechanism and they were assigned to the well-absorbed compounds. Other 23 isoflavonoid compounds were assigned to the poorly absorbed compounds.
    CONCLUSIONS:
    Because of the rats of Papp AP→BL/Papp BL→AP of 5-hydroxylononin, genistin, lanceolarin, kakkanin, and genistein-7-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside were 0.18, 0.28, 0.45, 0.38, 0.49, they may have been involved in the efflux mechanism in Caco-2 cells monolayer model from the BL side to AP side direction.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7778 mL 8.8889 mL 17.7778 mL 35.5556 mL 44.4444 mL
    5 mM 0.3556 mL 1.7778 mL 3.5556 mL 7.1111 mL 8.8889 mL
    10 mM 0.1778 mL 0.8889 mL 1.7778 mL 3.5556 mL 4.4444 mL
    50 mM 0.0356 mL 0.1778 mL 0.3556 mL 0.7111 mL 0.8889 mL
    100 mM 0.0178 mL 0.0889 mL 0.1778 mL 0.3556 mL 0.4444 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    6''-O-丙二酰基大豆苷; Daidzin 6''-O-malonate CFN91028 124590-31-4 C24H22O12 = 502.42 5mg QQ客服:2159513211
    8-O-Methylretusin-7-O-beta-D-glucopyranoside; 8-O-Methylretusin-7-O-beta-D-glucopyranoside CFN92917 68862-13-5 C23H24O10 = 460.43 5mg QQ客服:2932563308
    芒柄花苷; Ononin CFN99136 486-62-4 C22H22O9 = 430.4 20mg QQ客服:1413575084
    大豆苷元-4',7-二葡萄糖苷; Daidzein-4',7-diglucoside CFN95094 53681-67-7 C27H30O14 = 578.5 10mg QQ客服:3257982914
    毛蕊异黄酮-7-O-beta-D-葡萄糖苷; 毛蕊异黄酮苷; Calycosin-7-O-beta-D-glucoside CFN99141 20633-67-4 C22H22O10 = 446.40 20mg QQ客服:2159513211
    3'-甲氧基大豆苷; 3'-Methoxydaidzin CFN89443 200127-80-6 C22H22O10 = 446.40 10mg QQ客服:215959384
    大豆苷元-4’-葡萄糖苷; Daidzein-4'-glucoside CFN95142 58970-69-7 C21H20O9 = 416.4 5mg QQ客服:1148253675
    槐角苷; Sophoricoside CFN90148 152-95-4 C21H20O10 = 432.38 20mg QQ客服:1148253675
    新化合物III; New compound 3 CFN95184 N/A C27H30O15 = 594.5 5mg QQ客服:1148253675
    槐属双苷; Sophorabioside CFN90958 2945-88-2 C27H30O14 = 578.52 10mg QQ客服:215959384

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