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  • 3'-羟基葛根素

    3'-Hydroxy Puerarin

    3'-羟基葛根素
    产品编号 CFN90236
    CAS编号 117076-54-5
    分子式 = 分子量 C21H20O10 = 432.38
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Pueraria lobata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    3'-羟基葛根素 CFN90236 117076-54-5 10mg QQ客服:2932563308
    3'-羟基葛根素 CFN90236 117076-54-5 20mg QQ客服:2932563308
    3'-羟基葛根素 CFN90236 117076-54-5 50mg QQ客服:2932563308
    3'-羟基葛根素 CFN90236 117076-54-5 100mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Medicine and Pharmacy (Romania)
  • Subang Jaya Medical Centre (Malaysia)
  • Julius Kühn-Institut (Germany)
  • China Medical University (Taiwan)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Aveiro University (Portugal)
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  • Harvard University (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Anticancer Res.2014, 34(7):3505-9
  • FEBS Lett.2015, 589(1):182-7
  • SBRAS2016, 12
  • University of Limpopo2016, 1777
  • Chemistr of plant2016, 2016021195
  • Nat Prod Sci.2016, 22(2)
  • PLoS One.2017, 12(3):e0173585
  • Biochem Biophys Res Commun.2017, 482(4):1095-1101
  • J Nat Med.2017, 71(4):745-756
  • Exp Neurobiol.2018, 27(3):200-209
  • Phytomedicine.2018, 38:45-56
  • Cell Death Dis.2019, 10(12):882
  • J Adv Res.2019, 17:85-94
  • BMC Complement Altern Med.2019, 19(1):325
  • Int J Mol Sci.2019, 20(9):E2244
  • Molecules.2019, 24(2):329
  • J Ethnopharmacol.2019, 241:112025
  • Food Chem.2019, 290:286-294
  • Anal Sci.2019, 35(12):1317-1325
  • Phytomedicine.2019, 58:152893
  • Biomolecules.2019, 9(11):E696
  • Appl Biochem Biotechnol.2020, 190(2):732-744
  • Molecules2020, 25(4):892
  • ...
  • 生物活性
    Description: 3'-Hydroxy Puerarin may have anti-inflammatory and antioxidant activities, it shows marked ONOO−, NO·, total ROS scavenging activities, and weak ·O2− scavenging activity.3'-Hydroxy Puerarin also can improve the insulin resistance via up-regulating the expression of PPARγ in 3T3-L1 adipocytes.
    Targets: NOS | COX | ROS | PPAR | NO
    In vitro:
    Arch. Pharm. Res., 2012, 35(5):823-37.
    Anti-inflammatory and antioxidant activities of constituents isolated from Pueraria lobata roots.[Pubmed: 22644850 ]

    METHODS AND RESULTS:
    In order to evaluate the anti-inflammatory and antioxidant activities of Pueraria lobata roots and its active components, in vitro inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) protein expression, and tert-butylhydroperoxide (t-BHP)-induced reactive oxygen species (ROS) generation in RAW 264.7 cells, as well as in vitro scavenging activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH), peroxynitrite (ONOO(-)), nitric oxide (NO·), superoxide anion (·O(2)(-)) and total ROS, and inhibitory activities against ONOO(-)-mediated tyrosine nitration, were determined. Repeated column chromatography was performed to isolate four known compounds from the anti-inflammatory and antioxidant EtOAc fraction: daidzein; genistein; puerarin; (+)-puerarol B-2-O-glucopyranoside; four known compounds from the anti-inflammatory n-hexane fraction: lupenone; lupeol; puerarol; coumestrol; seven known compounds from the antioxidant n-BuOH fraction: allantoin; 3'-Hydroxy Puerarin; daidzein 8-C-apiosyl-(1→6)-glucoside; puerarin; genistin; 3'-methoxypuerarin; daidzin. Among these compounds, lupenone and lupeol reduced NO production, as well as iNOS and COX-2 protein levels in LPS-stimulated RAW 264.7 cells. Furthermore, lupeol showed significant inhibitory activity against intracellular ROS generation by t-BHP. Meanwhile, 3'-Hydroxy Puerarin showed marked ONOO(-), NO·, total ROS scavenging activities, and weak ·O(2)(-) scavenging activity, while 3'-methoxypuerarin showed ONOO(-) scavenging activity and weak NO· and O(2)(-) scavenging activities, suggesting that existence of the 3'-hydroxyl group in puerarin plays an important role in the scavenging of ONOO(-), NO·, and total ROS, as well as inhibiting the ONOO(-)-mediated tyrosine nitration mechanism.
    CONCLUSIONS:
    These results indicate that P. lobata roots and its constituents may be a useful therapeutic and preventive approach to various inflammatory diseases and oxidative stress-related disease.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3128 mL 11.5639 mL 23.1278 mL 46.2556 mL 57.8195 mL
    5 mM 0.4626 mL 2.3128 mL 4.6256 mL 9.2511 mL 11.5639 mL
    10 mM 0.2313 mL 1.1564 mL 2.3128 mL 4.6256 mL 5.782 mL
    50 mM 0.0463 mL 0.2313 mL 0.4626 mL 0.9251 mL 1.1564 mL
    100 mM 0.0231 mL 0.1156 mL 0.2313 mL 0.4626 mL 0.5782 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    射干苷; Tectoridin CFN99921 611-40-5 C22H22O11 = 462.40 20mg QQ客服:2159513211
    鸢尾黄素-7-O-木糖基葡萄糖苷; Tectorigenin 7-O-xylosylglucoside CFN90784 231288-19-0 C27H30O15 = 594.5 5mg QQ客服:2159513211
    葛花苷; Kakkalide CFN95052 58274-56-9 C28H32O15 = 608.6 10mg QQ客服:3257982914
    鸢尾甲苷A; Iristectorin A CFN95037 37744-61-9 C23H24O12 = 492.4 5mg QQ客服:2159513211
    野鹫尾苷 ; Iridin CFN96557 491-74-7 C24H26O13 = 522.46 20mg QQ客服:1413575084
    葛根素芹菜糖苷; Mirificin CFN90643 103654-50-8 C26H28O13 = 548.49 20mg QQ客服:2159513211
    3'-羟基葛根素芹菜糖苷; 3'-Hydroxymirificin CFN95102 168035-02-7 C26H28O14 = 564.5 5mg QQ客服:215959384
    3'-甲氧基葛根素芹菜糖苷; 3'-Methoxymirificin CFN95112 1297609-29-0 C27H30O14 = 578.5 5mg QQ客服:2159513211
    4'-O-甲氧基葛根素; 4'-Methoxypuerarin CFN90782 92117-94-7 C22H22O9 = 430.4 10mg QQ客服:1148253675
    葛根素-6''-O-木糖苷; Puerarin 6''-O-xyloside CFN90640 114240-18-5 C26H28O13 = 548.49 20mg QQ客服:1413575084

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