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  • 大豆苷

    Daidzin

    大豆苷
    产品编号 CFN99101
    CAS编号 552-66-9
    分子式 = 分子量 C21H20O9 = 416.38
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Pueraria lobata.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    大豆苷 CFN99101 552-66-9 10mg QQ客服:3257982914
    大豆苷 CFN99101 552-66-9 20mg QQ客服:3257982914
    大豆苷 CFN99101 552-66-9 50mg QQ客服:3257982914
    大豆苷 CFN99101 552-66-9 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Limpopo (South Africa)
  • Ain Shams University (Egypt)
  • Universidade de Franca (Brazil)
  • Shanghai Institute of Organic Chemistry (China)
  • Charles University in Prague (Czech Republic)
  • Korea Institute of Oriental Medicine (Korea)
  • Georgia Institute of Technology (USA)
  • University of Toulouse (France)
  • Tokyo Woman's Christian University (Japan)
  • University of Ioannina (Greece)
  • National Chung Hsing University (Taiwan)
  • Semmelweis Unicersity (Hungary)
  • Srinakharinwirot University (Thailand)
  • Mahidol University (Thailand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Ind Crops Prod.2014, 62:173-178
  • Acta Physiologiae Plantarum2015, 37:1736
  • J Separation Science & Technology2016, 51:1579-1588
  • Biochem Systematics and Ecology2017, 11-18
  • Nat Prod Commun.2017, 12(5):771-778
  • Phytochemistry.2017, 141:162-170
  • Sci Rep. 2017, 17332(7)
  • Front Immunol.2017, 8:1542
  • Front Aging Neurosci.2018, 10:269
  • PLoS One.2018, 13(4):e0195642
  • Malaysian J of Fundamental and Applied Sciences 2018, 14(3):368-373
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
  • Journal of Physiology & Pathology in Korean Medicine.2018, 32(2): 106-112
  • Sci Adv.2018, 4(10)
  • Front Pharmacol.2018, 9:236
  • APMIS.2019, 127(10):688-695
  • Cardiovasc Toxicol.2019, 19(4):297-305
  • Asian Pac J Cancer Prev.2019, 20(1):65-72
  • J Funct Foods2019, 54:449-456
  • Int Immunopharmacol.2019, 71:361-371
  • Food Sci Nutr.2019, 8(1):246-256
  • Genes Genomics.2020, 10.1007
  • Pharmacological Reports2020, 1-9
  • ...
  • 生物活性
    Description: Daidzin is a potent, selective aldehyde dehydrogenase 2 (ALDH2,IC50 = 80 nM) inhibitor, which has antiallergic anti-oxidant, anti-carcinogenic, antithrombotic,and anti-atherosclerotic activities, It has preventive effect on bone loss in ovariectomized rats appears to be due to suppression of bone turnover. A mixture of daidzin and glycitin has anti-obese and anti-diabetic effects.
    Targets: IL Receptor | ALDH2
    In vivo:
    Biosci Biotechnol Biochem. 2015 Jan;79(1):117-23.
    Anti-obese and anti-diabetic effects of a mixture of daidzin and glycitin on C57BL/6J mice fed with a high-fat diet.[Pubmed: 25209298]

    METHODS AND RESULTS:
    We investigated the effects of a mixture of daidzin and glycitin, which are the glycoside-form isoflavones of daidzein and glycitein, respectively, on body weight, lipid levels, diabetic markers, and metabolism in a high-fat diet (HF) fed C57BL/6J mice for 92 days. The mice were divided into basic diet group (CON), HF group, and HF companied with the isoflavone mixture group (HFISO). Results showed that mice in HFISO had a significantly lower body weight and adipose tissue compared to HF group. Blood glucose, serum HbA1c, and serum insulin also showed lower levels in HFISO group. In addition, higher hepatic GSH level and lower serum 8-hydroxy-2'-deoxyguanosine (8-OHdG) level were found in HFISO group mice.
    CONCLUSIONS:
    This suggests that the regulation of oxidative stress by daidzin and glycitin was closely related to the suppression of adipose tissue and the progression of diabetes.
    J Hepatol. 2014 Dec 24. pii: S0168-8278(14)00943-X.
    Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice.[Pubmed: 25543082]
    Effective therapies for alcoholic liver disease are currently unavailable. The present study tested the efficacy of Alda-1, a specific aldehyde dehydrogenase 2 (ALDH2) activator, in treating alcoholic liver disease.
    METHODS AND RESULTS:
    Male C57BL/6J mice were exposed to alcohol for a time-course study on aldehyde metabolism. The specificity and efficacy of Alda-1 on activating hepatic ALDH2 and aldehyde clearance were determined by acute treatments. Then, mice were fed alcohol for 8 weeks with Alda-1 administration for the last 10 days to test the therapeutic potential of Alda-1. Lastly, H4IIEC3 cells were treated with ethanol, acetaldehyde, or 4-hydroxynonenal to define the link between aldehydes and hepatotoxicity. Alcohol feeding for 8 weeks induced hepatic ALDH2 dysfunction and aldehyde accumulation. One dose of Alda-1 administration elevated hepatic ALDH activity, which was blocked by the specific ALDH2 inhibitor, daidzin. Alda-1 accelerated acetaldehyde clearance after acute alcohol intoxication. Alda-1 treatment in the 8-week alcohol feeding model reversed liver damage along with reduction of hepatic aldehydes. Alda-1 re-activated transcription factors, upregulated fatty acid oxidation enzymes, and reversed steatosis. Alcohol-induced endoplasmic reticulum stress and apoptotic cell death were also attenuated by Alda-1. Acetaldehyde or 4-hydroxynonenal treatment to H4IIEC3 cells inactivated transcription factors and induced endoplasmic reticulum stress and apoptosis, while ethanol per se showed limited effects.
    CONCLUSIONS:
    Pharmacological activation of ALDH2 by Alda-1 reversed alcoholic steatosis and apoptosis through accelerating aldehyde clearance. This study indicates that ALDH2 is a promising molecular target and Alda-1 has therapeutic potential for treating alcoholic liver disease.
    Biol Pharm Bull. 2002 Oct;25(10):1328-32.
    Antithrombotic and antiallergic activities of daidzein, a metabolite of puerarin and daidzin produced by human intestinal microflora.[Pubmed: 12392089]
    To evaluate the antithrombotic activities of puerarin and daidzin from the rhizome of Pueraria lobata, in vitro and ex vivo inhibitory activities of these compounds and their metabolite, daidzein, were measured. These compounds inhibited ADP- and collagen-induced platelet aggregation. Daidzein was the most potent. However, when puerarin and daidzin were intraperitoneally administered, their antiaggregation activities were weaker than when these compounds were administered orally. When in vivo antithrombotic activities of these compounds against collagen and epinephrine were measured, these compounds showed significant protection from death due to pulmonary thrombosis in mice.
    METHODS AND RESULTS:
    To evaluate the antiallergic activity of puerarin, daidzin, and daidzein, their inhibitory effects on the release of beta-hexosaminidase from RBL 2H3 cells and on the passive cutaneous anaphylaxis (PCA) reaction in mice were examined. Daidzein exhibited potent inhibitory activity on the beta-hexosaminidase release induced by DNP-BSA and potently inhibited the PCA reaction in rats. Daidzein administered intraperitoneally showed the strongest inhibitory activity and significantly inhibited the PCA reaction at doses of 25 and 50mg/kg with inhibitory activity of 37 and 73%, respectively. The inhibitory activity of intraperitoneally administered daidzein was stronger than those of intraperitoneally and orally administered puerarin and daidzin.
    CONCLUSIONS:
    Therefore we believe that puerarin and daidzin in the rhizome of Pueraria lobata are prodrugs, which have antiallergic and antithrombotic activities, produced by intestinal microflora.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4017 mL 12.0083 mL 24.0165 mL 48.033 mL 60.0413 mL
    5 mM 0.4803 mL 2.4017 mL 4.8033 mL 9.6066 mL 12.0083 mL
    10 mM 0.2402 mL 1.2008 mL 2.4017 mL 4.8033 mL 6.0041 mL
    50 mM 0.048 mL 0.2402 mL 0.4803 mL 0.9607 mL 1.2008 mL
    100 mM 0.024 mL 0.1201 mL 0.2402 mL 0.4803 mL 0.6004 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4''-甲氧基大豆苷; 4''-methyloxy-Daidzin CFN93005 1195968-02-5 C22H22O9 = 430.40 5mg QQ客服:1148253675
    6''-O-丙二酰基大豆苷; Daidzin 6''-O-malonate CFN91028 124590-31-4 C24H22O12 = 502.42 5mg QQ客服:2159513211
    8-O-Methylretusin-7-O-beta-D-glucopyranoside; 8-O-Methylretusin-7-O-beta-D-glucopyranoside CFN92917 68862-13-5 C23H24O10 = 460.43 5mg QQ客服:2932563308
    芒柄花苷; Ononin CFN99136 486-62-4 C22H22O9 = 430.4 20mg QQ客服:1148253675
    大豆苷元-4',7-二葡萄糖苷; Daidzein-4',7-diglucoside CFN95094 53681-67-7 C27H30O14 = 578.5 10mg QQ客服:1148253675
    毛蕊异黄酮-7-O-beta-D-葡萄糖苷; 毛蕊异黄酮苷; Calycosin-7-O-beta-D-glucoside CFN99141 20633-67-4 C22H22O10 = 446.40 20mg QQ客服:2932563308
    3'-甲氧基大豆苷; 3'-Methoxydaidzin CFN89443 200127-80-6 C22H22O10 = 446.40 10mg QQ客服:2932563308
    大豆苷元-4’-葡萄糖苷; Daidzein-4'-glucoside CFN95142 58970-69-7 C21H20O9 = 416.4 5mg QQ客服:3257982914
    槐角苷; Sophoricoside CFN90148 152-95-4 C21H20O10 = 432.38 20mg QQ客服:1148253675
    新化合物III; New compound 3 CFN95184 N/A C27H30O15 = 594.5 5mg QQ客服:3257982914

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