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  • 3'-甲氧基葛根素

    3'-Methoxypuerarin

    3'-甲氧基葛根素
    产品编号 CFN90780
    CAS编号 117047-07-1
    分子式 = 分子量 C22H22O10 = 446.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Pueraria lobata
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    3'-甲氧基葛根素 CFN90780 117047-07-1 10mg QQ客服:2932563308
    3'-甲氧基葛根素 CFN90780 117047-07-1 20mg QQ客服:2932563308
    3'-甲氧基葛根素 CFN90780 117047-07-1 50mg QQ客服:2932563308
    3'-甲氧基葛根素 CFN90780 117047-07-1 100mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Wuerzburg (Germany)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • University of Lodz (Poland)
  • Subang Jaya Medical Centre (Malaysia)
  • Chinese University of Hong Kong (China)
  • University of Fribourg (Switzerland)
  • University of Virginia (USA)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • National Cancer Institute (USA)
  • University of Eastern Finland (Finland)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Sant Gadge Baba Amravati University (India)
  • University of Limpopo (South Africa)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Auburn University2015, 1-58
  • SBRAS2016, 12
  • University of Limpopo2016, 1-237
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • Int J Mol Med.2016, 37(2):501-8
  • J Exp Bot.2016, 67(12):3777-88
  • Phytochemistry.2017, 141:162-170
  • International. J. of Food Properties 2017, 20:S131-S140
  • Universidade Estadual Paulista2017, 42785
  • J Pharm Biomed Anal.2018, 151:32-41
  • Sci Rep. 2018, 1-9
  • Exp Parasitol.2018, 194:67-78
  • Nat Prod Sci.2018, 24(3):206
  • Bioorg Med Chem.2018, 26(14):4201-4208
  • Cell Death Dis.2019, 10(12):882
  • Analytical methods2019, 11(6)
  • ACS Chem Biol.2019, 14(5):873-881
  • Molecules.2019, 24(16):E3003
  • FASEB J.2019, 33(2):2026-2036
  • Phytomedicine.2019, 67:153159
  • Sci Rep.2019, 9:19059
  • J of Applied Pharmaceutical Science2020, 10(1):077-082
  • J Nat Med.2020, 74(1):65-75
  • ...
  • 生物活性
    Description: 3'-Methoxypuerarin shows neuron protection activity, it can protect hippocampal neurons against ischemia/reperfusion injury by inhibiting apoptosis. 3'-Methoxypuerarin has antioxidant activities, it shows ONOO(-) scavenging activity and weak NO· and O(2)(-) scavenging activities.
    Targets: NO | ROS
    In vitro:
    Arch. Pharm. Res., 2012, 35(5):823-37.
    Anti-inflammatory and antioxidant activities of constituents isolated from Pueraria lobata roots.[Pubmed: 22644850 ]
    In order to evaluate the anti-inflammatory and antioxidant activities of Pueraria lobata roots and its active components, in vitro inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide (NO) production, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) protein expression, and tert-butylhydroperoxide (t-BHP)-induced reactive oxygen species (ROS) generation in RAW 264.7 cells, as well as in vitro scavenging activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH), peroxynitrite (ONOO(-)), nitric oxide (NO·), superoxide anion (·O(2)(-)) and total ROS, and inhibitory activities against ONOO(-)-mediated tyrosine nitration, were determined.
    METHODS AND RESULTS:
    Repeated column chromatography was performed to isolate four known compounds from the anti-inflammatory and antioxidant EtOAc fraction: daidzein; genistein; puerarin; (+)-puerarol B-2-O-glucopyranoside; four known compounds from the anti-inflammatory n-hexane fraction: lupenone; lupeol; puerarol; coumestrol; seven known compounds from the antioxidant n-BuOH fraction: allantoin; 3'-hydroxypuerarin; daidzein 8-C-apiosyl-(1→6)-glucoside; puerarin; genistin; 3'-methoxypuerarin; daidzin. Among these compounds, lupenone and lupeol reduced NO production, as well as iNOS and COX-2 protein levels in LPS-stimulated RAW 264.7 cells. Furthermore, lupeol showed significant inhibitory activity against intracellular ROS generation by t-BHP. Meanwhile, 3'-hydroxypuerarin showed marked ONOO(-), NO·, total ROS scavenging activities, and weak ·O(2)(-) scavenging activity, while 3'-methoxypuerarin showed ONOO(-) scavenging activity and weak NO· and O(2)(-) scavenging activities, suggesting that existence of the 3'-hydroxyl group in puerarin plays an important role in the scavenging of ONOO(-), NO·, and total ROS, as well as inhibiting the ONOO(-)-mediated tyrosine nitration mechanism.
    CONCLUSIONS:
    These results indicate that P. lobata roots and its constituents may be a useful therapeutic and preventive approach to various inflammatory diseases and oxidative stress-related disease.
    In vivo:
    Chinese Journal of Physiology, 2010, 53(2):136-40.
    Protection by 3'-methoxypuerarin of rat hippocampal neurons against ischemia/reperfusion injury.[Pubmed: 21793321]
    3'-Methoxypuerarin (3'-MOP) is an isoflavone extracted from radix puerariae. The aim of this study was to investigate the role and the mechanism of 3'-MOP in the protection of hippocampal neurons against cerebral ischemia/reperfusion (I/R) injury in rats.
    METHODS AND RESULTS:
    I/R injury was induced by a modified four-vessel occlusion model. Rats were randomly divided into an I/R group, an I/R + 3'-MOP group and a control group. Histological changes in the neurons of the hippocampal CA1 region were observed with hematoxylin and eosine (H&E) staining. The apoptotic neurons in the hippocampal CA1 area were counted with the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining.
    CONCLUSIONS:
    The results showed that compared with the I/R group, 3'-MOP increased the number of surviving neurons in the hippocampal CA1 region (P < 0.001) and markedly reduced the number of apoptotic pyramidal neurons (P < 0.001) after I/R injury. In conclusion, 3'-MOP can protect hippocampal neurons against I/R injury by inhibiting apoptosis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2401 mL 11.2007 mL 22.4014 mL 44.8029 mL 56.0036 mL
    5 mM 0.448 mL 2.2401 mL 4.4803 mL 8.9606 mL 11.2007 mL
    10 mM 0.224 mL 1.1201 mL 2.2401 mL 4.4803 mL 5.6004 mL
    50 mM 0.0448 mL 0.224 mL 0.448 mL 0.8961 mL 1.1201 mL
    100 mM 0.0224 mL 0.112 mL 0.224 mL 0.448 mL 0.56 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    4'-O-甲氧基葛根素; 4'-Methoxypuerarin CFN90782 92117-94-7 C22H22O9 = 430.4 10mg QQ客服:215959384
    葛根素-6''-O-木糖苷; Puerarin 6''-O-xyloside CFN90640 114240-18-5 C26H28O13 = 548.49 20mg QQ客服:215959384
    Formononetin-8-C-beta-D-apiofuranosyl-(1→6)-O-beta-D-glucopyranoside; Formononetin-8-C-beta-D-apiofuranosyl-(1->6)-O-beta-D-glucopyranoside CFN95157 1147858-78-3 C27H30O13 = 562.5 10mg QQ客服:3257982914
    美佛辛-4'-O-葡萄糖苷; Mirificin-4'-O-glucoside CFN95091 168035-01-6 C32H38O18 = 710.6 5mg QQ客服:1413575084
    3'-羟基葛根素; 3'-Hydroxy Puerarin CFN90236 117076-54-5 C21H20O10 = 432.38 20mg QQ客服:3257982914
    3'-甲氧基葛根素; 3'-Methoxypuerarin CFN90780 117047-07-1 C22H22O10 = 446.4 20mg QQ客服:2159513211
    大豆苷; Daidzin CFN99101 552-66-9 C21H20O9 = 416.38 20mg QQ客服:2159513211
    大豆苷元-7-O-葡萄糖醛酸苷; Daidzein 7-O-glucuronide CFN70352 38482-80-3 C21H18O10 = 430.4 5mg QQ客服:2159513211
    二氢大豆苷; Dihydrodaidzin CFN90755 121927-96-6 C21H22O9 = 418.4 5mg QQ客服:2932563308
    4''-甲氧基大豆苷; 4''-methyloxy-Daidzin CFN93005 1195968-02-5 C22H22O9 = 430.40 5mg QQ客服:1413575084

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