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  • 山芹醇

    Oroselol

    山芹醇
    产品编号 CFN95001
    CAS编号 1891-25-4
    分子式 = 分子量 C14H12O4 = 244.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The herbs of Peucedanum decursivum Maxim.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    山芹醇 CFN95001 1891-25-4 1mg QQ客服:3257982914
    山芹醇 CFN95001 1891-25-4 5mg QQ客服:3257982914
    山芹醇 CFN95001 1891-25-4 10mg QQ客服:3257982914
    山芹醇 CFN95001 1891-25-4 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Parma (Italy)
  • University of Minnesota (USA)
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  • Universidad Miguel Hernández (Spain)
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  • Medizinische Universit?t Wien (Austria)
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  • Macau University of Science and Technology (China)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2015, 16(1):1232-51
  • Acta Agriculturae Scandinavica2015, 381-383
  • J Agric Food Chem.2015, 63(44):9869-78
  • Appl Microbiol Biotechnol.2016, 100(9):3965-77
  • Pharm Biol.2016, 54(7):1255-62
  • Free Radic Biol Med.2016, 97:307-319
  • Universidade Estadual Paulista2017, 11449
  • Acta horticulturae2017, 1158:257-268
  • Pharmacognosy Magazine2017, 13(52):868-874
  • Molecules.2017, 22(2)
  • Phytochemistry Letters2017, 449-455
  • Mol Pharm.2018, 15(8):3285-3296
  • J Pharm Biomed Anal.2018, 151:32-41
  • Molecules.2018, 23(10):E2638
  • Molecules.2018, 23(7):E1659
  • Exp Neurobiol.2018, 27(3):200-209
  • J Adv Res.2019, 17:85-94
  • Spectrochim Acta A2019, 210:372-380
  • Molecules.2019, 24(21):E3834
  • Planta Med.2019, 85(4):347-355
  • Psychopharmacology (Berl).2020, 10.1007
  • Industrial Crops and Products2020, 146:112186
  • Molecules.2020, 25(3):734
  • ...
  • 生物活性
    Description: Oroselol, jatamansinol, nardostachysin, jatamansinone and nardosinone are Nardostachys jatamansi rhizome extract marker compounds.
    Targets: VEGFR | CDK | Bcl-2/Bax | EGFR | NO
    In vitro:
    Curr Cancer Drug Targets. 2017;17(1):74-88.
    Strong Anti-tumorous Potential of Nardostachys jatamansi Rhizome Extract on Glioblastoma and In Silico Analysis of its Molecular Drug Targets.[Pubmed: 27774879]
    Glioblastoma has been reckoned as the prime cause of death due to brain tumours, being the most invasive and lethal. Available treatment options, i.e. surgery, radiotherapy, chemotherapy and targeted therapies are not effective in improving prognosis, so an alternate therapy is insistent. Plant based drugs are efficient due to their synergistic action, multi-targeted approach and least side effects.
    METHODS AND RESULTS:
    The anti-tumorous potential of Nardostachys jatamansi rhizome extract (NJRE) on U87 MG cell line was evaluated through various in vitro and in silico bio-analytical tools. NJRE had a strong anti-proliferative effect on U87 MG cells, Its IC50 was 33.73±3.5, 30.59±3.4 and 28.39±2.9 μg/mL, respectively after 24, 48 and 72 h. NJRE at 30 μg/mL induced DNA fragmentation, indicating apoptosis, early apoptosis began in the cells at 20 μg/mL, whereas higher doses exhibited late apoptosis as revealed by dual fluorescence staining. NJRE at 60 and 80 μg /mL caused a G0/G1 arrest and at 20 and 40 μg/mL showed excessive nucleation and mitotic catastrophe in the cells. Immuno-blotting validated the apoptotic mode of cell death through intrinsic pathway. NJRE was harmless to normal cells. In silico docking of NJRE marker compounds: oroselol, jatamansinol, nardostachysin, jatamansinone and nardosinone have revealed their synergistic and multi-targeted interactions with Vestigial endothelial growth factor receptor 2 (VEGFR2), Cyclin dependent kinase 2 (CDK2), B-cell lymphoma 2 (BCL2) and Epidermal growth factor receptor (EGFR).
    CONCLUSIONS:
    A strong dose specific and time dependent anti-tumorous potential of NJRE on U87 MG cells was seen. The extract can be used for the development of safe and multi-targeted therapy to manage glioblastoma, which has not been reported earlier.
    Phytochemistry. 2012 Sep;81:109-16.
    Biotransformation of columbianadin by rat hepatic microsomes and inhibition of biotransformation products on NO production in RAW 264.7 cells in vitro.[Pubmed: 22784551 ]
    Columbianadin (CBN, 1), 1-[(8S)-8,9-dihydro-2-oxo-2H-furo[2,3-h]-1-benzopyran-8-yl]-1-methylethyl-[(2Z)-2-methyl-2-butenoic acid]ester is a coumarin-type compound and one of the main bioactive constituents of the underground part of Angelica pubescens Maxim. f. biserrata Shan et Yuan.
    METHODS AND RESULTS:
    Although numerous investigations have been undertaken to study the biological activities of CBN, such as analgesic, anti-inflammatory, calcium-channel blocking, and platelet aggregation inhibiting functions, little attention has been paid to its metabolism and/or biotransformation. Biotransformation of CBN by rat liver microsomes in vitro was studied, and thirteen biotransformation products including eight hitherto unknown compounds [columbianadiratimetins A-H (3-10)] and five known compounds [columbianadin oxide (2), (+)-2,3-dihydro-4-hydroxy-2-(1-hydroxy-1-methylethyl)-5-benzofurancarboxaldehyde (11), oroselol (12), columbianetin (13), and vaginol (14)] were produced by liver microsomes from rats pre-treated with sodium phenobarbital. The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses which included IR, UV, EIMS, HRESIMS, 1D NMR and 2D NMR, respectively.
    CONCLUSIONS:
    The inhibition of CBN and its main biotransformation products on nitric oxide production induced by lipopolysaccharide was assayed in RAW 264.7 cells at concentrations ranging from 10 to 200 μM to evaluate the biological significance of biotransformation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.095 mL 20.475 mL 40.95 mL 81.9001 mL 102.3751 mL
    5 mM 0.819 mL 4.095 mL 8.19 mL 16.38 mL 20.475 mL
    10 mM 0.4095 mL 2.0475 mL 4.095 mL 8.19 mL 10.2375 mL
    50 mM 0.0819 mL 0.4095 mL 0.819 mL 1.638 mL 2.0475 mL
    100 mM 0.041 mL 0.2048 mL 0.4095 mL 0.819 mL 1.0238 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    川白芷素; Angenomalin CFN91029 18199-64-9 C14H12O3 = 228.24 5mg QQ客服:3257982914
    山芹醇; Oroselol CFN95001 1891-25-4 C14H12O4 = 244.2 5mg QQ客服:1413575084
    二氢山芹醇; Columbianetin CFN90185 3804-70-4 C14H14O4 = 246.26 20mg QQ客服:2932563308
    Angelidiol; Angelidiol CFN92989 156009-77-7 C14H14O5 = 262.26 5mg QQ客服:2159513211
    二氢山芹醇醋酸酯; Columbianetin acetate CFN90510 23180-65-6 C16H16O5 = 288.30 20mg QQ客服:215959384
    二氢欧山芹醇当归酸酯; Columbianadin CFN99785 5058-13-9 C19H20O5 = 328.36 20mg QQ客服:3257982914
    二氢山芹醇 β-D-葡萄糖苷; Columbianetin beta-D-glucopyranoside CFN95038 55836-35-6 C20H24O9 = 408.4 5mg QQ客服:215959384
    Apterin; Apterin CFN95005 53947-89-0 C20H24O10 = 424.4 10mg QQ客服:215959384
    3'-Angeloyloxy-4'-senecioyloxy-2',3'-dihydrooroselol; 3'-Angeloyloxy-4'-senecioyloxy-2',3'-dihydrooroselol CFN95123 1221686-60-7 C24H26O7 = 426.5 5mg QQ客服:2932563308

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