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  • 二氢山芹醇醋酸酯

    Columbianetin acetate

    二氢山芹醇醋酸酯
    产品编号 CFN90510
    CAS编号 23180-65-6
    分子式 = 分子量 C16H16O5 = 288.30
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The roots of Angelica biserrata.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    二氢山芹醇醋酸酯 CFN90510 23180-65-6 10mg QQ客服:1413575084
    二氢山芹醇醋酸酯 CFN90510 23180-65-6 20mg QQ客服:1413575084
    二氢山芹醇醋酸酯 CFN90510 23180-65-6 50mg QQ客服:1413575084
    二氢山芹醇醋酸酯 CFN90510 23180-65-6 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Heidelberg University (Germany)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Texas A&M University (USA)
  • Colorado State University (USA)
  • Donald Danforth Plant Science Center (USA)
  • Wageningen University (Netherlands)
  • Hamdard University (India)
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  • University of Brasilia (Brazil)
  • University of Maryland School of Medicine (USA)
  • University of Medicine and Pharmacy (Romania)
  • Weizmann Institute of Science (Israel)
  • University of Parma (Italy)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • BMC Complement Altern Med.2014, 14:352
  • J Pharm Biomed Anal2016, 118:183-194
  • J. Soc. Cosmet. Sci. Korea2016, 163-171
  • J Agric Food Chem.2016, 64(35):6783-90
  • Nat Prod Commun.2017, 12(5):771-778
  • J of L. Chroma.&Related Tech2017, 252-258
  • Neurochem Int.2018, 121:114-124
  • BMC Plant Biol.2018, 18(1):122
  • Molecules.2018, 23(12):E3103
  • Phytother Res.2018, 32(5):923-932
  • Sci Rep. 2018, 462(8)
  • Korean Journal of Pharmacognosy2018, 49(1):76-83
  • Pharmacol Rep.2018, 70(6):1195-1201
  • Eur J Pharmacol.2018, 832:96-103
  • Biorxiv2019, 10.1101
  • Plant Physiol Biochem.2019, 144:355-364
  • Int J Mol Sci.2019, 20(8):E1855
  • Molecules.2019, 24(1):E159
  • Molecules.2019, 24(21):E3834
  • J Mol Histol.2019, 50(4):343-354
  • J Funct Foods2019, 54:449-456
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • Biochem Biophys Res Commun.2020, 522(1):40-46
  • ...
  • 生物活性
    Description: Columbianetin may be helpful in regulating mast cell-mediated allergic inflammatory responses, the absorption of columbianetin acetate is a passive diffusion process without pH-dependent.
    Targets: Immunology & Inflammation related
    In vitro:
    Zhong Xi Yi Jie He Xue Bao. 2008 Apr;6(4):392-8.
    Absorption and transport of 6 coumarins isolated from the roots of Angelica pubescens f. biserrata in human Caco-2 cell monolayer model[Pubmed: 18405608]
    To study the absorption and transepithelial transport of six coumarins (umbelliferone, osthole, columbianadin, columbianetin acetate, angelol-A and angelol-B, isolated from the roots of Angelica pubescens f. biserrata) in the human Caco-2 cell monolayer model.
    METHODS AND RESULTS:
    The in vitro cultured human colon carcinoma cell line, Caco-2 cell monolayer model, was applied to study the absorption and transport of the six coumarins from apical (AP) to basolateral (BL) side and from BL to AP side. The six coumarins were measured by reversed-phase high-performance liquid chromatography (HPLC) coupled with ultraviolet absorption detector. Transport parameters and apparent permeability coefficients (P(app)) were calculated and compared with those of propranolol as a control substance of high permeability and atenolol as a control substance of poor permeability. The transport mechanism of angelol-B was assayed by using iodoacetamide as a reference standard to inhibit ATP-dependent transport and MK571 as a well-known inhibitor of MRP2. The absorption and transport of six coumarins were passive diffusion as the dominating process. The P(app) values of umbelliferone, osthole, columbianadin, columbianetin acetate, angelol-A and angelol-B from AP to BL side were (2.679+/-0.263) x 10(-5), (1.306+/-0.324) x 10(-5), (0.595+/-0.086) x 10(-6), (2.930+/-0.410) x 10(-6), (1.532+/-0.444) x 10(-5) and (1.413+/-0.243) x 10(-5) cm/s, and from BL to AP side were (3.381+/-0.410) x 10(-5), (0.898+/-0.134) x 10(-5), (0.510+/-0.183) x 10(-6), (0.222+/-0.025) x 10(-6), (1.203+/-0.280) x 10(-5) and (0.754+/-0.092) x 10(-5) cm/s, respectively. In this assay, the P(app) value of propranolol was 2.18 x 10(-5) cm/s and the P(app) value of atenolol was 2.77 x 10(-7) cm/s. Among the 6 coumarins, the P(app) values of umbelliferone, osthole, angelol-A and angelol-B from AP to BL side were identical with that of propranolol, and columbianadin and columbianetin acetate lied between propranolol and atenolol. When replaced the HBSS with EBSS, and iodoacetamide or MK-591 were used in the experiment, the P(app) of angelol-B had no statistical difference as compared with the control group. In the mean total recoveries, umbelliferone was (83.31+/-3.52)%, angelol-A was (77.39+/-7.38)%, osthole, columbianadin and angelol-B were between 50% to 65%, and columbianetin acetate was lower than 10%. The accumulation rates of osthole and columbianadin in the Caco-2 cells were (36.15+/-5.87)% and (53.90+/-4.39)%, respectively.
    CONCLUSIONS:
    The absorption and transport of umbelliferone, osthole, columbianadin, columbianetin acetate, angelol-A and angelol-B are passive diffusion as the dominating process in Caco-2 cell monolayer model. Umbelliferone, osthole, angelol-A and angelol-B are estimated to be highly absorbed compounds, and columbianadin and columbianetin acetate are estimated to be moderately absorbed compounds. In the Caco-2 cells, osthol and columbianadin appear to accumulate, and columbianetin acetate may be metabolized. The absorption and transport of angelol-B are not influenced by the change of pH and the presence of iodoacetamide or MK571.
    In vivo:
    Planta Med. 1995 Feb;61(1):2-8.
    Anti-inflammatory and analgesic activities from roots of Angelica pubescens.[Pubmed: 7700984]

    METHODS AND RESULTS:
    In the present study, we extracted Angelica pubescens (AP) with various solvents in order to find the bioactive constituents that demonstrated analgesic and anti-inflammatory effects. The results were obtained as follows: (1) Methanol-, chloroform-, and ethyl acetate-extracts effectively reduced the pain that was induced by 1% acetic acid and a hot plate. (2) Methanol-, chloroform-, and ethyl acetate-extracts reduced the edema that was induced by 3% formalin or 1.5% carrageenan. (3) Sixteen compounds have been isolated and identified from the roots of AP. Among these compounds, columbianadin, columbianetin acetate, bergapten, umbelliferone, and caffeic acid significantly demonstrated anti-inflammatory and analgesic activities at 10 mg/kg. However, only osthole and xanthotoxin revealed anti-inflammatory activity. Isoimperatorin only demonstrated an analgesic effect.
    CONCLUSIONS:
    These results revealed that the anti-inflammatory and analgesic constituents from roots of AP were related to peripheral inhibition of inflammatory substances and to the influence on the central nervous system.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.4686 mL 17.343 mL 34.6861 mL 69.3722 mL 86.7152 mL
    5 mM 0.6937 mL 3.4686 mL 6.9372 mL 13.8744 mL 17.343 mL
    10 mM 0.3469 mL 1.7343 mL 3.4686 mL 6.9372 mL 8.6715 mL
    50 mM 0.0694 mL 0.3469 mL 0.6937 mL 1.3874 mL 1.7343 mL
    100 mM 0.0347 mL 0.1734 mL 0.3469 mL 0.6937 mL 0.8672 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    川白芷素; Angenomalin CFN91029 18199-64-9 C14H12O3 = 228.24 5mg QQ客服:2932563308
    山芹醇; Oroselol CFN95001 1891-25-4 C14H12O4 = 244.2 5mg QQ客服:2159513211
    二氢山芹醇; Columbianetin CFN90185 3804-70-4 C14H14O4 = 246.26 20mg QQ客服:215959384
    Angelidiol; Angelidiol CFN92989 156009-77-7 C14H14O5 = 262.26 5mg QQ客服:1413575084
    二氢山芹醇醋酸酯; Columbianetin acetate CFN90510 23180-65-6 C16H16O5 = 288.30 20mg QQ客服:1148253675
    二氢欧山芹醇当归酸酯; Columbianadin CFN99785 5058-13-9 C19H20O5 = 328.36 20mg QQ客服:1148253675
    二氢山芹醇 β-D-葡萄糖苷; Columbianetin beta-D-glucopyranoside CFN95038 55836-35-6 C20H24O9 = 408.4 5mg QQ客服:2932563308
    Apterin; Apterin CFN95005 53947-89-0 C20H24O10 = 424.4 10mg QQ客服:2932563308
    3'-Angeloyloxy-4'-senecioyloxy-2',3'-dihydrooroselol; 3'-Angeloyloxy-4'-senecioyloxy-2',3'-dihydrooroselol CFN95123 1221686-60-7 C24H26O7 = 426.5 5mg QQ客服:3257982914

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