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  • 二氢欧山芹醇当归酸酯

    Columbianadin

    二氢欧山芹醇当归酸酯
    产品编号 CFN99785
    CAS编号 5058-13-9
    分子式 = 分子量 C19H20O5 = 328.36
    产品纯度 >=98%
    物理属性 White cryst.
    化合物类型 Coumarins
    植物来源 The herbs of Angelicae pubescens
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    二氢欧山芹醇当归酸酯 CFN99785 5058-13-9 10mg QQ客服:2932563308
    二氢欧山芹醇当归酸酯 CFN99785 5058-13-9 20mg QQ客服:2932563308
    二氢欧山芹醇当归酸酯 CFN99785 5058-13-9 50mg QQ客服:2932563308
    二氢欧山芹醇当归酸酯 CFN99785 5058-13-9 100mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Complutense University of Madrid (Spain)
  • Cornell University (USA)
  • Imperial College London (United Kingdom)
  • The Institute of Cancer Research (United Kingdom)
  • University of Wuerzburg (Germany)
  • University of Queensland (Australia)
  • University of Madras (India)
  • University of Ioannina (Greece)
  • Nanjing University of Chinese Medicine (China)
  • Utah State University (USA)
  • University of Padjajaran (Indonesia)
  • Texas A&M University (USA)
  • University of Canterbury (New Zealand)
  • University of Eastern Finland (Finland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules. 2013, 18(7):7376-88
  • Phytochemistry Letters2015, 243-247
  • J-STAGE2015, 249-255
  • University of Limpopo2016, 1-237
  • J Med Food.2016, 19(12):1155-1165
  • Chemistr of plant2016, 2016021195
  • Eur J Pharm Sci.2016, 94:33-45
  • Biochem Systematics and Ecology2017, 11-18
  • Nat Prod Commun.2017, 12(5):771-778
  • J Ethnopharmacol.2017, 198:91-97
  • Food Chem.2017, 228:301-314
  • Sci Rep.2017, 7:40345
  • Biol Pharm Bull.2018, 41(1):65-72
  • Sci Rep.2018, 8(1):12970
  • Postharvest Biol Tec2019, 149:18-26
  • Molecules.2019, 24(11):E2044
  • Chin J Appl. Physiol.2019, 35(3):283-288
  • Environ Toxicol Pharmacol.2019, 66:109-115
  • Planta Med.2019, 85(3):217-224
  • J Cell Physiol.2020, 10.1002
  • Plant Foods Hum Nutr.2020, 10.1007
  • Biomedicine & Pharmacotherapy2020, 125:109950
  • Antioxidants (Basel).2020, 9(2):E120
  • ...
  • 生物活性
    Description: Columbianadin has analgesic, anti-inflammatory, calcium-channel blocking, and platelet aggregation inhibiting functions. It can effectively suppress the growth of colon cancer cells, the induction of apoptosis was correlated with the modulation of caspase-9, caspase-3, Bax, Bcl-2, RIP-3, and caspase-8, Bim and Bid.
    Targets: Caspase | Bcl-2/Bax | ROS | IL Receptor | NO | Calcium Channel | RIP-3 | SOD | GPx-1
    In vitro:
    Phytochemistry. 2012 Sep;81:109-16.
    Biotransformation of columbianadin by rat hepatic microsomes and inhibition of biotransformation products on NO production in RAW 264.7 cells in vitro.[Pubmed: 22784551]
    Columbianadin (CBN, 1), 1-[(8S)-8,9-dihydro-2-oxo-2H-furo[2,3-h]-1-benzopyran-8-yl]-1-methylethyl-[(2Z)-2-methyl-2-butenoic acid]ester is a coumarin-type compound and one of the main bioactive constituents of the underground part of Angelica pubescens Maxim. f. biserrata Shan et Yuan. Although numerous investigations have been undertaken to study the biological activities of Columbianadin, such as analgesic, anti-inflammatory, calcium-channel blocking, and platelet aggregation inhibiting functions, little attention has been paid to its metabolism and/or biotransformation.
    METHODS AND RESULTS:
    Biotransformation of Columbianadin by rat liver microsomes in vitro was studied, and thirteen biotransformation products including eight hitherto unknown compounds [columbianadiratimetins A-H (3-10)] and five known compounds [Columbianadin oxide (2), (+)-2,3-dihydro-4-hydroxy-2-(1-hydroxy-1-methylethyl)-5-benzofurancarboxaldehyde (11), oroselol (12), columbianetin (13), and vaginol (14)] were produced by liver microsomes from rats pre-treated with sodium phenobarbital. The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses which included IR, UV, EIMS, HRESIMS, 1D NMR and 2D NMR, respectively.
    CONCLUSIONS:
    The inhibition of Columbianadin and its main biotransformation products on nitric oxide production induced by lipopolysaccharide was assayed in RAW 264.7 cells at concentrations ranging from 10 to 200 μM to evaluate the biological significance of biotransformation.
    In vivo:
    J Ethnopharmacol. 2014 Sep 11;155(2):1353-61.
    Inhibition of airway inflammation by the roots of Angelica decursiva and its constituent, columbianadin.[Pubmed: 25068578]
    The roots of Angelica decursiva Fr. Et Sav (Umbelliferae) have been frequently used in traditional medicine as anti-inflammatory, antitussive, analgesic agents and expectorant, especially for treating cough, asthma, bronchitis and upper respiratory tract infections. To establish the scientific rationale for the clinical use of Angelica decursiva and to identify new agents for treating inflammatory lung disorders, pharmacological evaluation of the roots of Angelica decursiva and the isolated constituents was performed.
    METHODS AND RESULTS:
    In vitro study was carried out using two lung cells, lung epithelial cells (A549) and alveolar macrophages (MH-S). The inflammatory markers such as IL-6 and nitric oxide (NO) for each cell line were examined. For in vivo study, a mouse model of lipopolysaccharide (LPS)-induced acute lung injury was used and the effects on lung inflammation were established by measuring the cell numbers in bronchoalveolar lavage fluid (BALF) and by histological observation. Water and 70% ethanol extracts of the roots of Angelica decursiva showed considerable inhibitory activity against LPS-induced lung inflammation in mice following oral administration at a dose of 400 mg/kg. Five coumarin derivatives including Columbianadin, umbelliferone, umbelliferone 6-carboxylic acid, nodakenin and nodakenetin were isolated. Among the isolated compounds, Columbianadin was found to possess strong inhibitory activity against the inflammatory response of IL-1β-treated A549 cells and LPS-treated MH-S cells. Columbianadin was found to inhibit NO production by down-regulation of inducible NO synthase. Moreover, Columbianadin was also proved to possess significant inhibitory activity against LPS-induced lung inflammation following oral administration at a dose of 20-60 mg/kg.
    CONCLUSIONS:
    The roots of Angelica decursiva were proved to be effective in the treatment of lung inflammation. Columbianadin can be a potential new agent for treating inflammatory lung disorders.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0454 mL 15.2272 mL 30.4544 mL 60.9088 mL 76.1359 mL
    5 mM 0.6091 mL 3.0454 mL 6.0909 mL 12.1818 mL 15.2272 mL
    10 mM 0.3045 mL 1.5227 mL 3.0454 mL 6.0909 mL 7.6136 mL
    50 mM 0.0609 mL 0.3045 mL 0.6091 mL 1.2182 mL 1.5227 mL
    100 mM 0.0305 mL 0.1523 mL 0.3045 mL 0.6091 mL 0.7614 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    川白芷素; Angenomalin CFN91029 18199-64-9 C14H12O3 = 228.24 5mg QQ客服:3257982914
    山芹醇; Oroselol CFN95001 1891-25-4 C14H12O4 = 244.2 5mg QQ客服:215959384
    二氢山芹醇; Columbianetin CFN90185 3804-70-4 C14H14O4 = 246.26 20mg QQ客服:2159513211
    Angelidiol; Angelidiol CFN92989 156009-77-7 C14H14O5 = 262.26 5mg QQ客服:1413575084
    二氢山芹醇醋酸酯; Columbianetin acetate CFN90510 23180-65-6 C16H16O5 = 288.30 20mg QQ客服:2159513211
    二氢欧山芹醇当归酸酯; Columbianadin CFN99785 5058-13-9 C19H20O5 = 328.36 20mg QQ客服:1413575084
    二氢山芹醇 β-D-葡萄糖苷; Columbianetin beta-D-glucopyranoside CFN95038 55836-35-6 C20H24O9 = 408.4 5mg QQ客服:2159513211
    Apterin; Apterin CFN95005 53947-89-0 C20H24O10 = 424.4 10mg QQ客服:2932563308
    3'-Angeloyloxy-4'-senecioyloxy-2',3'-dihydrooroselol; 3'-Angeloyloxy-4'-senecioyloxy-2',3'-dihydrooroselol CFN95123 1221686-60-7 C24H26O7 = 426.5 5mg QQ客服:2932563308

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