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  • 二氢山芹醇

    Columbianetin

    二氢山芹醇
    产品编号 CFN90185
    CAS编号 3804-70-4
    分子式 = 分子量 C14H14O4 = 246.26
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Coumarins
    植物来源 The roots of Angelica pubescens.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    二氢山芹醇 CFN90185 3804-70-4 10mg QQ客服:1148253675
    二氢山芹醇 CFN90185 3804-70-4 20mg QQ客服:1148253675
    二氢山芹醇 CFN90185 3804-70-4 50mg QQ客服:1148253675
    二氢山芹醇 CFN90185 3804-70-4 100mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Federal de Goias (UFG) (Brazil)
  • Sant Gadge Baba Amravati University (India)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Center for protein Engineering (CIP) (Belgium)
  • University Medical Center Mainz (Germany)
  • University of Canterbury (New Zealand)
  • Monash University (Australia)
  • Northeast Normal University Changchun (China)
  • Instytut Nawozów Sztucznych w Pu?awach (Poland)
  • Worcester Polytechnic Institute (USA)
  • Imperial College London (United Kingdom)
  • Florida International University (USA)
  • Weizmann Institute of Science (Israel)
  • Instituto Politécnico de Bragan?a (Portugal)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Biol Chem.2014, 289(3):1723-31
  • Nat Prod Commun.2014, 9(5):679-82
  • Mediators Inflamm.2016, 2016:7216912
  • African J. Agricultural Research 2017, 12(13):1164-1168
  • J Pharm Biomed Anal.2017, 140:274-280
  • J Ethnopharmacol.2017, 206:327-336
  • Molecules.2017, 22(12)
  • Molecules.2017, 22(3)
  • JPC-Journal of Planar Chromatography 2017, 30(2)
  • J.Acta Agriculturae Scandinavica2017, 571-575
  • Sci Rep. 2017, 8207(7)
  • Pharmacognosy Magazine2018, 14(56):418-424
  • Phytomedicine.2018, 40:37-47
  • Curr Eye Res.2018, 43(1):27-34
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1113:1-13
  • J of Essential Oil Research2019, 1677272
  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • J Ethnopharmacol.2019, 228:132-141
  • Phytomedicine.2019, 59:152785
  • Appl Biol Chem2019, 62:46
  • J Mater Chem B.2019, 7(39):5896-5919
  • Int J Food Sci Nutr.2019, 70(7):825-833
  • Food Sci Nutr.2019, 8(1):246-256
  • ...
  • 生物活性
    Description: Columbianetin is a new phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage, it also has antifungal activity. Columbianetin has anti-inflammatory effects, it promotes histamine release, and inhibits the histamine release by substance P, suggests that it may be helpful in regulating mast cell-mediated allergic inflammatory responses. (2'S)-columbianetin can be effectively used to protect keratinocytes from UVB induced damage.
    Targets: COX | IL Receptor | TNF-α | NF-kB | NOS | ROS | MAPK | AP-1
    In vitro:
    J Photochem Photobiol B. 2012 Apr 2;109:20-7.
    Protective effect of (2'S)-columbianetin from Corydalis heterocarpa on UVB-induced keratinocyte damage.[Pubmed: 22321694 ]
    A salt tolerant plant, Corydalis heterocarpa has been used as a folk medicine to treat travail and spasm. Recent studies have also reported antioxidant and antiinflammatory activities of compounds isolated from C. heterocarpa. In this study, the protective effect of (2'S)-Columbianetin isolated from C. heterocarpa on UVB-induced human keratinocyte (HaCaT) damage was investigated.
    METHODS AND RESULTS:
    First, the appropriate energy level of UVB irradiation was determined using MTT and LDH assays. And then the protective effect of (2'S)-Columbianetin on UVB induced HaCaT damage was evaluated by measuring; the changes in cell viability, LDH release level, ROS generation, cell cycle arrest and MMP expression levels. Finally, the effect of compound on MAPK and AP-1 signaling pathways were studied to understand the underlying signaling mechanisms. Result demonstrated that the presence of (2'S)-Columbianetin suppressed the reactive oxygen species (ROS) generation, cell cycle arrest at sub-G1 phase and down regulation of MMP expression in UVB treated HaCaT cells. Furthermore, stress activated signaling pathways (ASK1-MAPK) and AP-1 signaling pathway were regulated by (2'S)-Columbianetin treatment.
    CONCLUSIONS:
    These results suggest that (2'S)-Columbianetin could be effectively used to protect human keratinocytes from UVB induced damage.
    Phytochemistry, 1995, 39(6):1347-50.
    Columbianetin, a phytoalexin associated with celery resistance to pathogens during storage.[Reference: WebLink]
    Columbianetin, rather than psoralens, was found to be a new phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage.
    METHODS AND RESULTS:
    In vitro, Columbianetin had at least 80 times greater antifungal activity than furanocoumarins (psoralens and angelicin). In vivo, the concentration of furanocoumarins in celery was 8μg g−1 fr. wt, and this is less than 0.25% of the concentration required for growth inhibition of celery pathogens. However, the concentration of Columbianetin in vivo was 38μg g−1 fr. wt, and this is close to the concentration required for growth inhibition of celery pathogens in vitro.
    In vivo:
    J Ethnopharmacol. 2013 Oct 28;150(1):175-80.
    The pharmacokinetics and oral bioavailability studies of columbianetin in rats after oral and intravenous administration.[Pubmed: 23994338]
    The roots of Angelica pubescens Maxim. f. biserrata Shan et Yuan (RAP) has been used as Traditional Chinese medicine to treat rheumatic disease in China since ancient times, but its action mechanisms was not well understood. Columbianetin is one of the main active constituents isolated from RAP, which has been shown to have various biological activities, but the absorption characteristics and oral bioavailability dose proportionality of columbianetin in vivo were not studied.
    METHODS AND RESULTS:
    Male Sprague Dawley rats (210-230 g) received either an intravenous (i.v. 5, 10 and 20 mg kg(-1)) or oral (5, 10 and 20 mg kg(-1)) dose of columbianetin. The levels of columbianetin in plasma were measured by a simple and sensitive reversed-phase high-performance liquid chromatography (HPLC) method. The simple liquid-liquid extraction with ethyl acetate was used for sample preparation. Osthole was selected as internal standard (IS). The chromatographic separation was accomplished on a C18 column at a flow rate of 1 mL min(-1), where water-methanol was used as mobile phase. The calibration curve of the method was linear in the concentration range of 0.05-2000 μg mL(-1). The intra and inter-day accuracy for columbianetin in rat plasma samples were within 8% and the variation was less than 8.3%. This method was suitable for the determination and pharmacokinetic study of columbianetin in rat plasma after both intravenous and oral administration. The results indicated that maximum plasma concentrations(Cmax) for the columbianetin (17-42 μg mL(-1)) were achieved at 0.3-0.5h post-oral dosing and the apparent volume of distribution (V/F) ranged from 0.38 to 0.44 L. Absolute bioavailability of columbianetin was assessed to be 81.13 ± 45.85, 81.09 ± 33.63 and 54.30 ± 23.19%, respectively. Terminal elimination half-life (T1/2) of the columbianetin after oral dosing was 60-90 min and were 2.5-3.3 fold longer than those observed for the i.v. dosing.
    CONCLUSIONS:
    The pharmacokinetic properties of columbianetin in rat after oral administration were characterized as rapid oral absorption, quick clearance and good absolute bioavailability. The bioavailability of columbianetin ranged from 54 to 81% for 5, 10 and 20 mg kg(-1) oral doses. The bioavailability of columbianetin is independent of the doses studied. Columbianetin showed dose proportionality over the dose range 5-20 mg kg(-1). The results clearly demonstrated that columbianetin was one of the material bases of RAP. Furthermore, an HPLC method was demonstrated in this study for the research of traditional Chinese medicine.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0607 mL 20.3037 mL 40.6075 mL 81.215 mL 101.5187 mL
    5 mM 0.8121 mL 4.0607 mL 8.1215 mL 16.243 mL 20.3037 mL
    10 mM 0.4061 mL 2.0304 mL 4.0607 mL 8.1215 mL 10.1519 mL
    50 mM 0.0812 mL 0.4061 mL 0.8121 mL 1.6243 mL 2.0304 mL
    100 mM 0.0406 mL 0.203 mL 0.4061 mL 0.8121 mL 1.0152 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    川白芷素; Angenomalin CFN91029 18199-64-9 C14H12O3 = 228.24 5mg QQ客服:1148253675
    山芹醇; Oroselol CFN95001 1891-25-4 C14H12O4 = 244.2 5mg QQ客服:1413575084
    二氢山芹醇; Columbianetin CFN90185 3804-70-4 C14H14O4 = 246.26 20mg QQ客服:215959384
    Angelidiol; Angelidiol CFN92989 156009-77-7 C14H14O5 = 262.26 5mg QQ客服:1148253675
    二氢山芹醇醋酸酯; Columbianetin acetate CFN90510 23180-65-6 C16H16O5 = 288.30 20mg QQ客服:215959384
    二氢欧山芹醇当归酸酯; Columbianadin CFN99785 5058-13-9 C19H20O5 = 328.36 20mg QQ客服:2932563308
    二氢山芹醇 β-D-葡萄糖苷; Columbianetin beta-D-glucopyranoside CFN95038 55836-35-6 C20H24O9 = 408.4 5mg QQ客服:215959384
    Apterin; Apterin CFN95005 53947-89-0 C20H24O10 = 424.4 10mg QQ客服:2932563308
    3'-Angeloyloxy-4'-senecioyloxy-2',3'-dihydrooroselol; 3'-Angeloyloxy-4'-senecioyloxy-2',3'-dihydrooroselol CFN95123 1221686-60-7 C24H26O7 = 426.5 5mg QQ客服:1413575084

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