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  • 去甲黄腐醇

    Desmethylxanthohumol

    去甲黄腐醇
    产品编号 CFN92015
    CAS编号 115063-39-3
    分子式 = 分子量 C20H20O5 = 340.4
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Chalcones
    植物来源 The herbs of Humulus lupulus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    去甲黄腐醇 CFN92015 115063-39-3 1mg QQ客服:1413575084
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    去甲黄腐醇 CFN92015 115063-39-3 10mg QQ客服:1413575084
    去甲黄腐醇 CFN92015 115063-39-3 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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  • Univerzita Karlova2022, 228192.
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  • ...
  • 生物活性
    Description: Desmethylxanthohumol shows estrogenic activity.
    In vitro:
    Planta Medica, 2009, 75(07):757-762.
    Dynamic Residual Complexity of Natural Products by qHNMR: Solution Stability of Desmethylxanthohumol.[Reference: WebLink]
    The use of chromatographic assays to assess the residual complexity of materials that are purified from natural sources by chromatographic means is, in a sense, a case of the fox watching the henhouse. Beside their static residual complexity, which is intrinsic to their metabolic origin, biologically active natural materials can also be involved in chemical reactions that lead to dynamic residual complexity.
    METHODS AND RESULTS:
    The present study examines the dynamics of the hop prenylphenol, desmethylxanthohumol (DMX), by means of quantitative ¹H-NMR (qHNMR) in a setting that mimics in vitro and physiological conditions. The experiments provide a comprehensive, time-resolved, and mechanistic picture of the spontaneous isomerization of DMX into congeneric flavanones, including their ¹H/²D isotopomers. Formation of the potent phytoestrogen, 8-prenylnaringenin (8PN), suggests that measurable estrogenic activity even of high-purity DMX is an artifact. Together with previously established qHNMR assays including purity activity relationships (PARs), dynamic qHNMR assays complement important steps of the post-isolation evaluation of natural products.
    CONCLUSIONS:
    Thus, qHNMR allows assessment of several unexpected effects that potentially break the assumed linkage between a single chemical entity (SCE) and biological endpoints.
    Eur J Med Chem . 2017 Jan 5;125:335-345.
    Synthesis and antioxidant evaluation of desmethylxanthohumol analogs and their dimers[Pubmed: 27688188]
    Abstract Four ring-closed analogs of natural prenylated chalcone desmethylxanthohumol (1) and their dimers were synthesized from the commercially available 1-(2,4,6-trihydroxyphenyl)ethan-1-one in five and six linear steps, respectively. The structures of the eight new derivatives were confirmed using1H NMR, 13C NMR and HRMS. The antioxidant activity of the new chalcone derivatives were evaluated in a PC12 cell model of H2O2-induced oxidative damage. The SAR studies suggested that the catechol motif was essential for the antioxidant activity. Moreover, the dimers showed better antioxidant activity than their corresponding monomers did. Among them, compound 14d was the most potent and increased PC12 cell viability from 25% to 85%. Flow cytometric analysis showed that compound 14d, the most potent compound, decreased the apoptotic PC12 cell percentage and significantly reduced the LDH release and 8-OHdG generation but increased the GSH levels in H2O2-treated PC12 cells. Furthermore, compound 14d had a higher FRAP value than that of gallic acid. It also reduced the stable ABTS+ free radical with a lower EC50 than that of gallic acid. Keywords: Antioxidant; Chalcone; Desmethylxanthohumol; Dimer; Synthesis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9377 mL 14.6886 mL 29.3772 mL 58.7544 mL 73.443 mL
    5 mM 0.5875 mL 2.9377 mL 5.8754 mL 11.7509 mL 14.6886 mL
    10 mM 0.2938 mL 1.4689 mL 2.9377 mL 5.8754 mL 7.3443 mL
    50 mM 0.0588 mL 0.2938 mL 0.5875 mL 1.1751 mL 1.4689 mL
    100 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.5875 mL 0.7344 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    补骨脂查耳酮; Bavachalcone CFN92221 28448-85-3 C20H20O4 = 324.4 5mg QQ客服:2056216494
    4'-O-甲基补骨脂查尔酮; 4'-O-Methylbroussochalcone B CFN98046 20784-60-5 C21H22O4 = 338.4 20mg QQ客服:1457312923
    补骨脂乙素; Isobavachalcone CFN98593 20784-50-3 C20H20O4 = 324.37 20mg QQ客服:1413575084
    去甲黄腐醇; Desmethylxanthohumol CFN92015 115063-39-3 C20H20O5 = 340.4 5mg QQ客服:2159513211
    黄腐醇; 黄腐酚; Xanthohumol CFN98958 569-83-5; 6754-58-1 C21H22O5 = 354.4 20mg QQ客服:2056216494
    黄腐醇D; 黄腐酚D; Xanthohumol D CFN98328 274675-25-1 C21H22O6 = 370.4 5mg QQ客服:1457312923
    Corylifol B; Corylifol B CFN92227 775351-90-1 C20H20O5 = 340.4 5mg QQ客服:3257982914
    摩查尔酮 A; Morachalcone A CFN97241 76472-88-3 C20H20O5 = 340.4 5mg QQ客服:3257982914
    次苦参素; Kuraridine CFN92006 34981-25-4 C26H30O6 = 438.5 5mg QQ客服:1457312923

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