Info: Read More
  • 中药标准品生产商,产品定制服务
  • 补骨脂乙素

    Isobavachalcone

    补骨脂乙素
    产品编号 CFN98593
    CAS编号 20784-50-3
    分子式 = 分子量 C20H20O4 = 324.37
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Chalcones
    植物来源 The fruits of Psoralea corylifolia L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    补骨脂乙素 CFN98593 20784-50-3 10mg QQ客服:3257982914
    补骨脂乙素 CFN98593 20784-50-3 20mg QQ客服:3257982914
    补骨脂乙素 CFN98593 20784-50-3 50mg QQ客服:3257982914
    补骨脂乙素 CFN98593 20784-50-3 100mg QQ客服:3257982914
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Maryland School of Medicine (USA)
  • Kyushu University (Japan)
  • Weizmann Institute of Science (Israel)
  • Istanbul University (Turkey)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • CSIRO - Agriculture Flagship (Australia)
  • Chulalongkorn University (Thailand)
  • University of East Anglia (United Kingdom)
  • Osmania University (India)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Chiang Mai University (Thailand)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J.the Korean Socie. Food Sci.&Nut.2023; 52(1):26-39.
  • Chinese Pharmacological Bulletin2019, 35(8):1120-1125
  • J Insect Sci.2020, 20(5):18.
  • EXCLI J.2023, 22:482-498.
  • Phytomedicine2022, 104:154337.
  • Molecular & Cellular Toxicology2017, 13(3):271-278
  • Cancers (Basel).2021, 13(9):2223.
  • Mol Med Rep.2014, 9(5):1653-9
  • Plant Cell,Tissue & Organ Culture2016, 127(1):115-121
  • Food Chem.2016, 191:81-90
  • Food Funct.2022, 13(14):7638-7649.
  • Evid Based Complement Alternat Med.2021, 8855980.
  • Plants (Basel).2021, 10(7):1376.
  • Phytochem Anal.2021, 32(6):970-981.
  • Molecules.2019, 24(9):E1719
  • Academic J of Second Military Medical University2019, 40(1)
  • Microorganisms.2021, 9(12):2514.
  • Preprints2022, 2022030063.
  • Evid Based Complement Alternat Med.2021, 2021:5319584.
  • Exp Parasitol.2015, 153:160-4
  • Phytomedicine.2021, 2(82):153452
  • Appl. Sci.2022, 12(4), 2032.
  • Nutrients.2019, 12(1):E40
  • ...
  • 生物活性
    Description: Isobavachalcone has anti-cancer, anthelmintic, antibacterial, aphrodisiac, anti-inflammatory, astringent and antiplatelet activities, Isobavachalcone can induce apoptotic cell death in neuroblastoma via the mitochondrial pathway; it can significantly inhibit both oligomerization and fibrillization of Aβ42; it can suppress inducible nitric oxide synthase (iNOS) expression induced by macrophage-activating lipopeptide 2-kDa, polyriboinosinic polyribocytidylic acid, or lipopolysaccharide.
    Targets: NF-kB | IFN-γ | TLR | Beta Amyloid | NOS | PARP | Caspase | PKC | Akt
    In vitro:
    Eur J Pharmacol. 2015 May 5;754:11-8.
    Isobavachalcone attenuates lipopolysaccharide-induced ICAM-1 expression in brain endothelial cells through blockade of toll-like receptor 4 signaling pathways.[Pubmed: 25704611]
    Inflammation has been implicated in the pathogenesis of various cerebral diseases. Thus, control of brain inflammation is regarded as one of the important therapeutic strategies for the treatment of neurodegenerative diseases such as Alzheimer׳s disease and stroke. Isobavachalcone, a flavonoid from Psoralea corylifolia, is known to possess a wide spectrum of biological activities and is expected to be useful in preventing or treating neurodegenerative diseases. However, very little is known regarding its effects on cerebral inflammation.
    METHODS AND RESULTS:
    In this study, we examined the effect of isobavachalcone on leukocyte adhesion and intercellular adhesion molecule-1 (ICAM-1) expression in brain endothelial cells activated with lipopolysaccharide (LPS) and explored the possible mechanisms involved. Isobavachalcone significantly down-regulated LPS-induced ICAM-1 expression and leukocyte-endothelial cell adhesion and suppressed NF-κB activity which is implicated in the expression of ICAM-1. It attenuated ICAM-1 expression as well as NF-κB transcriptional activity induced by macrophage-activating lipopeptide 2-kDa (MALP-2) or polyriboinosinic polyribocytidylic acid (poly[I:C]). Isobavachalcone also down-regulated LPS or poly[I:C]-induced expression of IFN-β, which can indirectly activate NF-κB. These data imply that isobavachalcone can modulate both MyD88-dependent and TRIF-dependent signaling of toll-like receptor 4 (TLR4).
    CONCLUSIONS:
    Taken together, our data suggest that isobavachalcone inhibits LPS-induced ICAM-1 expression and leukocyte adhesion to brain endothelial cell by blocking TLR4 signaling and thus, has the potential to ameliorate neuronal injury in brain diseases associated with inflammation.
    Int J Mol Med. 2012 Oct;30(4):939-44.
    Autophagy inhibition enhances isobavachalcone-induced cell death in multiple myeloma cells.[Pubmed: 22824846 ]
    Despite recent advancements in therapeutic drugs, multiple myeloma remains an incurable disease.
    METHODS AND RESULTS:
    Therefore, a more effective treatment is urgently required. In this study, we show that isobavachalcone (IBC), a natural chalcone compound, induces apoptosis- and autophagy-related cell death in myeloma cells. The inhibition of autophagy by knocking down beclin-1 or by using autophagy inhibitors, such as 3-methyladenine, bafilomycin A and chloroquine significantly enhanced IBC-induced cell death, as demonstrated by the increased number of Annexin V-positive cells. Moreover, we demonstrate that the collapse of the mitochondrial membrane potential contributes to chloroquine and IBC-induced cell death, which is accompanied by the activation of caspase-9, and -3, the cleavage of poly (ADP-ribose) polymerase (PARP) and the proteolytic activation of protein kinase Cδ (PKCδ). Furthermore, the inhibition of the activation of PKCδ by rottlerin, an inhibitor of PKCδ, not only suppressed the activation of PKCδ, but also the apoptosis induced by the co-treatment of chloroquine and IBC, indicating the involvement of PKCδ in chloroquine plus IBC-induced cell death. Finally, the combination of chloroquine and IBC had little effect on the viability of normal peripheral blood mononuclear cells.
    CONCLUSIONS:
    As both chloroquine and IBC have been shown to be relatively specific for cancer cells, the combination of these two agents at non-toxic or sub-toxic concentrations represents an attractive novel regimen for myeloma treatment and warrants further investigation in preclinical and clinical studies.
    Antimicrob Agents Chemother. 2010 May;54(5):1749-52.
    Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.[Pubmed: 20160051]
    The activities of two naturally occurring compounds, isobavachalcone and diospyrone, against documented strains and multidrug-resistant (MDR) Gram-negative bacterial isolates were evaluated.
    METHODS AND RESULTS:
    The results indicated that the two compounds exhibited intrinsic antibacterial activity against several Gram-negative bacteria, and their activities were significantly improved in the presence of an efflux pump inhibitor (MIC values decreased to below 10 microg/ml). In addition, the activities of isobavachalcone and diospyrone against various strains exhibiting deletions of the major efflux pump components (AcrAB, TolC) were significantly increased.
    CONCLUSIONS:
    The overall results indicate that isobavachalcone and diospyrone could be candidates for the development of new drugs against MDR strains and that their use in combination with efflux pump inhibitors reinforces their activity.
    Cancer Lett. 2010 Aug 28;294(2):167-77.
    Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells.[Pubmed: 20167420 ]
    Akt signaling pathway has attracted much attention as a promising target for cancer therapeutics. Herein, we report that Isobavachalcone (IBC), a natural chalcone, potently abrogates Akt signaling and exerts anti-proliferative effects on several human cancer cell lines.
    METHODS AND RESULTS:
    Modeling results from the Sybyl/FlexiDock program suggest that IBC potentially binds to the ATP-binding pocket of Akt, which is confirmed by the observations that IBC inhibits Akt1 kinase in vitro. Further studies reveal that IBC significantly abates Akt phosphorylation at Ser-473 and Akt kinase activity in cells, which subsequently leads to inhibition of Akt downstream substrates and evokes significant levels of apoptosis associated with mitochondria pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0829 mL 15.4145 mL 30.829 mL 61.658 mL 77.0725 mL
    5 mM 0.6166 mL 3.0829 mL 6.1658 mL 12.3316 mL 15.4145 mL
    10 mM 0.3083 mL 1.5414 mL 3.0829 mL 6.1658 mL 7.7072 mL
    50 mM 0.0617 mL 0.3083 mL 0.6166 mL 1.2332 mL 1.5414 mL
    100 mM 0.0308 mL 0.1541 mL 0.3083 mL 0.6166 mL 0.7707 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    补骨脂查耳酮; Bavachalcone CFN92221 28448-85-3 C20H20O4 = 324.4 5mg QQ客服:2056216494
    4'-O-甲基补骨脂查尔酮; 4'-O-Methylbroussochalcone B CFN98046 20784-60-5 C21H22O4 = 338.4 20mg QQ客服:1413575084
    补骨脂乙素; Isobavachalcone CFN98593 20784-50-3 C20H20O4 = 324.37 20mg QQ客服:3257982914
    去甲黄腐醇; Desmethylxanthohumol CFN92015 115063-39-3 C20H20O5 = 340.4 5mg QQ客服:2159513211
    黄腐醇; 黄腐酚; Xanthohumol CFN98958 569-83-5; 6754-58-1 C21H22O5 = 354.4 20mg QQ客服:2056216494
    黄腐醇D; 黄腐酚D; Xanthohumol D CFN98328 274675-25-1 C21H22O6 = 370.4 5mg QQ客服:3257982914
    Corylifol B; Corylifol B CFN92227 775351-90-1 C20H20O5 = 340.4 5mg QQ客服:215959384
    摩查尔酮 A; Morachalcone A CFN97241 76472-88-3 C20H20O5 = 340.4 5mg QQ客服:3257982914
    次苦参素; Kuraridine CFN92006 34981-25-4 C26H30O6 = 438.5 5mg QQ客服:3257982914

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产