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  • 补骨脂查耳酮

    Bavachalcone

    补骨脂查耳酮
    产品编号 CFN92221
    CAS编号 28448-85-3
    分子式 = 分子量 C20H20O4 = 324.4
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Chalcones
    植物来源 The seeds of Psoralea corylifolia L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    补骨脂查耳酮 CFN92221 28448-85-3 1mg QQ客服:1413575084
    补骨脂查耳酮 CFN92221 28448-85-3 5mg QQ客服:1413575084
    补骨脂查耳酮 CFN92221 28448-85-3 10mg QQ客服:1413575084
    补骨脂查耳酮 CFN92221 28448-85-3 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • The Australian National University (Australia)
  • Chulalongkorn University (Thailand)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Anna University (India)
  • Universiti Malaysia Pahang (Malaysia)
  • Florida International University (USA)
  • Nanjing University of Chinese Medicine (China)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • University of Leipzig (Germany)
  • Universidad de Buenos Aires (Argentina)
  • Technical University of Denmark (Denmark)
  • Harvard University (USA)
  • University of Bonn (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • The Korea Journal of Herbology2019, 34(2):25-32
  • Int J Med Sci.2021, 18(10):2155-2161.
  • Industrial Crops and Products2022, 188:115596.
  • Molecules.2022, 27(22):7997.
  • Asian Pac J Cancer Prev.2019, 20(1):65-72
  • Mol Cells.2018, 41(8):771-780
  • Biomed Pharmacother.2022, 145:112410.
  • Pathogens.2018, 7(3):E62
  • Tokyo Pharmaceutical University2020, 500001431953.
  • Toxicol Appl Pharmacol.2021, 427:115668.
  • BMC Complement Altern Med.2019, 19(1):339
  • Molecules.2022, 27(5):1675
  • J Microbiol Biotechnol.2020, 30(2):178-186.
  • Journal of Molecular Liquids2022, 364:120062.
  • J Sep Sci.2019, 42(21):3352-3362
  • Toxicol Rep.2021, 8:1131-1142.
  • Biomed Pharmacother.2022, 146:112497.
  • Industrial Crops and Products2020, 146:112186
  • Horticulture Research2023, uhad164.
  • Life (Basel).2021, 11(12):1399.
  • Korean J. Medicinal Crop Sci.2022, 30(2):124-133
  • J Appl Biol Chem2021, 64(3):245-251.
  • J Cell Biochem.2022, 123(7):1222-1236.
  • ...
  • 生物活性
    Description: Bavachalcone has antibiotic or anticancer activities, it may be useful as a therapeutic drug for bone resorption-associated diseases.Bavachalcone can protect the endothelial function by increasing AMPK activity and MnSOD expression and reducing mitochondrial oxidative stress.
    Targets: AMPK | SOD | MEK | ERK | Akt | NF-kB
    In vitro:
    Evid Based Complement Alternat Med. 2014;2014:958937.
    Comparison of the Inhibitory Potential of Bavachalcone and Corylin against UDP-Glucuronosyltransferases.[Pubmed: 24829606]
    Bavachalcone and corylin are two major bioactive compounds isolated from Psoralea corylifolia L., which has been widely used as traditional Chinese medicine for many years. As two antibiotic or anticancer drugs, Bavachalcone and corylin are used in combination with other drugs; thus it is necessary to evaluate potential pharmacokinetic herb-drug interactions (HDI) of the two bioactive compounds.
    METHODS AND RESULTS:
    The aim of the present study was to compare the effects of liver UDP-glucuronosyltransferase (UGT) 1A1, UGT1A3, UGT1A7, UGT1A8, UGT 1A10, and UGT2B4 inhibited by Bavachalcone and corylin. 4-Methylumbelliferone (4-MU) was used as a nonspecific "probe" substrate. Bavachalcone had stronger inhibition on UGT1A1 and UGT1A7 than corylin which did not inhibit UGT1A1, UGT1A3, UGT1A7, UGT1A8, UGT1A10, and UGT2B4. Data fitting using Dixon and Lineweaver-Burk plots demonstrated the noncompetitive inhibition of Bavachalcone against UGT1A1 and UGT1A7-mediated 4-MU glucuronidation reaction. The values of inhibition kinetic parameters (Ki) were 5.41  μ M and 4.51  μ M for UGT1A1 and UGT1A7, respectively.
    CONCLUSIONS:
    The results of present study suggested that there was a possibility of UGT1A1 and UGT1A7 inhibition-based herb-drug interaction associated with Bavachalcone and provided the basis for further in vivo studies to investigate the HDI potential between Bavachalcone and UGT substrates.
    Biochem Pharmacol. 2008 Jun 1;75(11):2175-82.
    Bavachalcone inhibits osteoclast differentiation through suppression of NFATc1 induction by RANKL.[Pubmed: 18433733]
    Osteoclasts are cells that have a specialized role for bone resorption and are responsible for many bone diseases such as osteoporosis. As herbal products are invaluable sources in discovery of compounds for new therapies, we sought to identify compounds efficacious in suppressing osteoclastogenesis from medicinal plants that have been implicated for treatment of osteoporotic conditions.
    METHODS AND RESULTS:
    Bavachalcone was isolated from Psoralea corylifolia, and its effects on osteoclast differentiation were evaluated with primary cultures of osteoclast precursor cells. In addition, the molecular mechanism of action was investigated. Bavachalcone inhibited osteoclast formation from precursor cells with the IC(50) of approximately 1.5 microg ml(-1). The activation of MEK, ERK, and Akt by receptor activator of nuclear factor kappaB ligand (RANKL), the osteoclast differentiation factor, was prominently reduced in the presence of Bavachalcone. The induction of c-Fos and NFATc1, key transcription factors for osteoclastogenesis, by RANKL was also suppressed by Bavachalcone. In conclusion, Bavachalcone inhibits osteoclastogenesis by interfering with the ERK and Akt signaling pathways and the induction of c-Fos and NFATc1 during differentiation.
    CONCLUSIONS:
    Our results suggest that Bavachalcone may be useful as a therapeutic drug for bone resorption-associated diseases.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0826 mL 15.4131 mL 30.8261 mL 61.6523 mL 77.0654 mL
    5 mM 0.6165 mL 3.0826 mL 6.1652 mL 12.3305 mL 15.4131 mL
    10 mM 0.3083 mL 1.5413 mL 3.0826 mL 6.1652 mL 7.7065 mL
    50 mM 0.0617 mL 0.3083 mL 0.6165 mL 1.233 mL 1.5413 mL
    100 mM 0.0308 mL 0.1541 mL 0.3083 mL 0.6165 mL 0.7707 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    补骨脂查耳酮; Bavachalcone CFN92221 28448-85-3 C20H20O4 = 324.4 5mg QQ客服:3257982914
    4'-O-甲基补骨脂查尔酮; 4'-O-Methylbroussochalcone B CFN98046 20784-60-5 C21H22O4 = 338.4 20mg QQ客服:1413575084
    补骨脂乙素; Isobavachalcone CFN98593 20784-50-3 C20H20O4 = 324.37 20mg QQ客服:3257982914
    去甲黄腐醇; Desmethylxanthohumol CFN92015 115063-39-3 C20H20O5 = 340.4 5mg QQ客服:1413575084
    黄腐醇; 黄腐酚; Xanthohumol CFN98958 569-83-5; 6754-58-1 C21H22O5 = 354.4 20mg QQ客服:2056216494
    黄腐醇D; 黄腐酚D; Xanthohumol D CFN98328 274675-25-1 C21H22O6 = 370.4 5mg QQ客服:2159513211
    Corylifol B; Corylifol B CFN92227 775351-90-1 C20H20O5 = 340.4 5mg QQ客服:3257982914
    摩查尔酮 A; Morachalcone A CFN97241 76472-88-3 C20H20O5 = 340.4 5mg QQ客服:2056216494
    次苦参素; Kuraridine CFN92006 34981-25-4 C26H30O6 = 438.5 5mg QQ客服:3257982914

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