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  • 摩查尔酮 A

    Morachalcone A

    摩查尔酮 A
    产品编号 CFN97241
    CAS编号 76472-88-3
    分子式 = 分子量 C20H20O5 = 340.4
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Chalcones
    植物来源 The roots of Morus alba.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    摩查尔酮 A CFN97241 76472-88-3 1mg QQ客服:2159513211
    摩查尔酮 A CFN97241 76472-88-3 5mg QQ客服:2159513211
    摩查尔酮 A CFN97241 76472-88-3 10mg QQ客服:2159513211
    摩查尔酮 A CFN97241 76472-88-3 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Florida A&M University (USA)
  • Agricultural Research Organization (ARO) (Israel)
  • Universite de Lille1 (France)
  • Korea Food Research Institute(KFRI) (Korea)
  • Indian Institute of Science (India)
  • Auburn University (USA)
  • University of Beira Interior (Portugal)
  • University of Virginia (USA)
  • Hamdard University (India)
  • Complutense University of Madrid (Spain)
  • University of Liège (Belgium)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • University of Wuerzburg (Germany)
  • University of Toronto (Canada)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Phytomedicine.2019, 55:229-237
  • Cell Prolif.2021, 54(8):e13083.
  • Korean J. Crop Sci.2018, 63(2):131-139
  • Cancers (Basel).2021, 13(9):2223.
  • Molecules.2019, 24(16):E3003
  • Food and Bioprocess Technology2017, 10(6):1074-1092
  • Molecules2022, 27(3),1140.
  • Food Chem.2019, 290:286-294
  • Food Addit Contam Part A.2021, 38(12):1985-1994.
  • RSC Adv.2018, 32621-32636
  • Nutrients2020, 12(3):811.
  • Asian Pac J Cancer Prev. 2020, 21(4):935-941.
  • Korean J. Medicinal Crop Sci.2022, 30(2):117-123.
  • Molecules.2021, 26(8):2161.
  • Institute of Food Science & Technology2021, 18 December.
  • Phytomedicine.2019, 58:152893
  • Asian J of Pharmaceutical&Clinical 2018, 11(2)
  • Molecules.2020, 25(15):3353.
  • Industrial Crops and Products2022, 186:115298
  • J of Food Quality2020, 8851285.
  • J Korean Soc Food Sci Nutr2023, 52(11):1101-1110
  • Pol J Microbiol.2021, 70(1):117-130.
  • Molecules.2019, 24(9):E1719
  • ...
  • 生物活性
    Description: Morachalcone A displays significant tyrosinase inhibitory activity (IC50, 0.013 uM); it also exerts strong pancreatic lipase inhibition with IC 50 value of 6.2 uM. Morachalcone A exhibits neuroprotective effects on HT22-immortalized hippocampal cells against glutamate-induced oxidative stress, with EC50 values of 35.5±2.1 uM. It exhibits potent inhibitory activity on nitric oxide production in RAW264.7 LPS-activated mouse macrophage cells with IC50 value of 16.4 microM.
    Targets: Tyrosinase | NO
    In vitro:
    J Med Food. 2015 Apr;18(4):403-8.
    Neuroprotective effect of prenylated arylbenzofuran and flavonoids from morus alba fruits on glutamate-induced oxidative injury in HT22 hippocampal cells.[Pubmed: 25514545]
    A prenylated arylbenzofuran and six flavonoids were isolated from the fruits of Morus alba L. through silica gel, octadecyl silica gel, and Diaion HP-20 column chromatography.
    METHODS AND RESULTS:
    Based on the nuclear magnetic resonance, mass spectrometry, and infrared spectroscopic data, the chemical structures of the compounds were determined to be artoindonesianin O (1), isobavachalcone (2), Morachalcone A (3), quercetin (4), astragalin (5), isoquercetin (6), and rutin (7). The isolated compounds were evaluated for protection of HT22-immortalized hippocampal cells against glutamate-induced oxidative stress.
    CONCLUSIONS:
    Compounds 1 and 3 exhibited protective effects with EC(50) values of 19.7±1.2 and 35.5±2.1 μM, respectively. The major compounds 1-3 and 7 were quantified using liquid chromatography/mass spectrometry analysis and were determined to be 1.88±2.1, 1.90±1.8, 0.78±1.5, and 37.29±2.2 mg/kg, respectively, in the ethanol extract of M. alba L. fruits.
    J Nat Prod. 2012 Nov 26;75(11):1951-5.
    Tyrosinase inhibitors from the wood of Artocarpus heterophyllus.[Pubmed: 23113717 ]

    METHODS AND RESULTS:
    From the methanolic-soluble extract of the wood of Artocarpus heterophyllus, four new flavones, artocarmins A-D (1-4), and three new chalcones, artocarmitins A-C (5-7), have been isolated together with 13 known compounds. Their structures were determined on the basis of the spectroscopic data.
    CONCLUSIONS:
    Compounds 1-4, 6, 7, 9-16, and 20 displayed significant tyrosinase inhibitory activity. The most active compound, morachalcone A (12) (IC50, 0.013 μM), was 3000 times more active as a tyrosinase inhibitor than a positive control, kojic acid (IC50, 44.6 μM).
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9377 mL 14.6886 mL 29.3772 mL 58.7544 mL 73.443 mL
    5 mM 0.5875 mL 2.9377 mL 5.8754 mL 11.7509 mL 14.6886 mL
    10 mM 0.2938 mL 1.4689 mL 2.9377 mL 5.8754 mL 7.3443 mL
    50 mM 0.0588 mL 0.2938 mL 0.5875 mL 1.1751 mL 1.4689 mL
    100 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.5875 mL 0.7344 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    补骨脂查耳酮; Bavachalcone CFN92221 28448-85-3 C20H20O4 = 324.4 5mg QQ客服:2056216494
    4'-O-甲基补骨脂查尔酮; 4'-O-Methylbroussochalcone B CFN98046 20784-60-5 C21H22O4 = 338.4 20mg QQ客服:1413575084
    补骨脂乙素; Isobavachalcone CFN98593 20784-50-3 C20H20O4 = 324.37 20mg QQ客服:1457312923
    去甲黄腐醇; Desmethylxanthohumol CFN92015 115063-39-3 C20H20O5 = 340.4 5mg QQ客服:1457312923
    黄腐醇; 黄腐酚; Xanthohumol CFN98958 569-83-5; 6754-58-1 C21H22O5 = 354.4 20mg QQ客服:1413575084
    黄腐醇D; 黄腐酚D; Xanthohumol D CFN98328 274675-25-1 C21H22O6 = 370.4 5mg QQ客服:1413575084
    Corylifol B; Corylifol B CFN92227 775351-90-1 C20H20O5 = 340.4 5mg QQ客服:2159513211
    摩查尔酮 A; Morachalcone A CFN97241 76472-88-3 C20H20O5 = 340.4 5mg QQ客服:1413575084
    次苦参素; Kuraridine CFN92006 34981-25-4 C26H30O6 = 438.5 5mg QQ客服:1457312923

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