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  • 4'-O-甲基补骨脂查尔酮

    4'-O-Methylbroussochalcone B

    4'-O-甲基补骨脂查尔酮
    产品编号 CFN98046
    CAS编号 20784-60-5
    分子式 = 分子量 C21H22O4 = 338.4
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Chalcones
    植物来源 The seeds of Psoralea corylifolia Linn.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    4'-O-甲基补骨脂查尔酮 CFN98046 20784-60-5 10mg QQ客服:2056216494
    4'-O-甲基补骨脂查尔酮 CFN98046 20784-60-5 20mg QQ客服:2056216494
    4'-O-甲基补骨脂查尔酮 CFN98046 20784-60-5 50mg QQ客服:2056216494
    4'-O-甲基补骨脂查尔酮 CFN98046 20784-60-5 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Fitoterapia.2021, 153:104995.
  • Cells.2023, 12(1):168.
  • Anal Bioanal Chem.2018, 410(5):1561-1569
  • APMIS.2019, 127(10):688-695
  • Appl. Sci.2021, 11(19),9343.
  • J Herbmed Pharmacol.2018, 7(4):280-286
  • Molecules.2017, 22(6)
  • Food Funct.2022, doi: 10.1039
  • Kaohsiung J Med Sci.2023, 10.1002/kjm2.12764
  • Appl. Sci.2020, 10(4),1304
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  • JEJU National University2022, 24032.
  • Molecules 2022, 27(3),1047.
  • BMC Plant Biol.2020, 20(1):214.
  • Pharmaceutics.2020, 12(9):845.
  • Data Science for Genomics2023, 107-128.
  • JAOCS2021, 98(7):779-794.
  • Front Nutr.2021, 8: 687851.
  • Molecules2022, 27(3),1140.
  • J Cell Mol Med.2023, 27(10):1423-1435.
  • Neuropharmacology2019, 151437
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  • 生物活性
    Description: Reference standards.
    In vitro:
    Journal of Natural Products,2018, 81(4):966-975.
    Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication.[Pubmed: 29641206]
    Postmenopausal women are increasingly using botanicals for menopausal symptom relief due to the increased breast cancer risk associated with traditional estrogen therapy. The deleterious effects of estrogens are associated with estrogen receptor (ER)α-dependent proliferation, while ERβ activation could enhance safety by opposing ERα effects.
    METHODS AND RESULTS:
    Three medicinal licorice species, Glycyrrhiza glabra ( G. glabra), G. uralensis, and G. inflata, were studied for their differential estrogenic efficacy. The data showed higher estrogenic potency for G. inflata in an alkaline phosphatase induction assay in Ishikawa cells (ERα) and an estrogen responsive element (ERE)-luciferase assay in MDA-MB-231/β41 breast cancer cells (ERβ). Bioassay-guided fractionation of G. inflata led to the isolation of 8-prenylapigenin (3). Surprisingly, a commercial batch of 3 was devoid of estrogenic activity. Quality control by MS and qNMR revealed an incorrect compound, 4'- O-methylbroussochalcone B (10), illustrating the importance of both structural and purity verification prior to any biological investigations. Authentic and pure 3 displayed 14-fold preferential ERβ agonist activity. Quantitative analyses revealed that 3 was 33 times more concentrated in G. inflata compared to the other medicinal licorice extracts.
    CONCLUSIONS:
    These data suggest that standardization of G. inflata to 3 might enhance the safety and efficacy of G. inflata supplements used for postmenopausal women's health.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.9551 mL 14.7754 mL 29.5508 mL 59.1017 mL 73.8771 mL
    5 mM 0.591 mL 2.9551 mL 5.9102 mL 11.8203 mL 14.7754 mL
    10 mM 0.2955 mL 1.4775 mL 2.9551 mL 5.9102 mL 7.3877 mL
    50 mM 0.0591 mL 0.2955 mL 0.591 mL 1.182 mL 1.4775 mL
    100 mM 0.0296 mL 0.1478 mL 0.2955 mL 0.591 mL 0.7388 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    补骨脂查耳酮; Bavachalcone CFN92221 28448-85-3 C20H20O4 = 324.4 5mg QQ客服:215959384
    4'-O-甲基补骨脂查尔酮; 4'-O-Methylbroussochalcone B CFN98046 20784-60-5 C21H22O4 = 338.4 20mg QQ客服:2159513211
    补骨脂乙素; Isobavachalcone CFN98593 20784-50-3 C20H20O4 = 324.37 20mg QQ客服:1457312923
    去甲黄腐醇; Desmethylxanthohumol CFN92015 115063-39-3 C20H20O5 = 340.4 5mg QQ客服:3257982914
    黄腐醇; 黄腐酚; Xanthohumol CFN98958 569-83-5; 6754-58-1 C21H22O5 = 354.4 20mg QQ客服:2159513211
    黄腐醇D; 黄腐酚D; Xanthohumol D CFN98328 274675-25-1 C21H22O6 = 370.4 5mg QQ客服:1413575084
    Corylifol B; Corylifol B CFN92227 775351-90-1 C20H20O5 = 340.4 5mg QQ客服:215959384
    摩查尔酮 A; Morachalcone A CFN97241 76472-88-3 C20H20O5 = 340.4 5mg QQ客服:3257982914
    次苦参素; Kuraridine CFN92006 34981-25-4 C26H30O6 = 438.5 5mg QQ客服:215959384

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