雷公藤次碱

Wilforine

	产品编号	CFN99207
	CAS编号	11088-09-8
	分子式 = 分子量	C₄₃H₄₉NO₁₈ = 867.9
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Sesquiterpenoids
	植物来源	The vines of Tripterygium wilfordii.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
雷公藤次碱	CFN99207	11088-09-8	10mg	QQ客服：2159513211
雷公藤次碱	CFN99207	11088-09-8	20mg	QQ客服：2159513211
雷公藤次碱	CFN99207	11088-09-8	50mg	QQ客服：2159513211
雷公藤次碱	CFN99207	11088-09-8	100mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Tohoku University (Japan)

Hamdard University (India)

Korea Institute of Oriental Medicine (Korea)

Copenhagen University (Denmark)

University of the Basque Country (Spain)

Uniwersytet Jagielloński w Krakowie (Poland)

Monash University Malaysia (Malaysia)

University of Dicle (Turkey)

University of Eastern Finland (Finland)

Subang Jaya Medical Centre (Malaysia)

University of Sao Paulo (Brazil)

The Institute of Cancer Research (United Kingdom)

Kyushu University (Japan)

Seoul National University of Science and Technology (Korea)

More...

Description:

Wilforine has anti-inflammatory effect, which might be mediated by down-regulation of the expression of inflammatory factors TNF-α, IL-6 and NO. It also has insecticidal activity by inhibiting the Na+-K+-ATPase in the central nervous system.

Targets:

In vitro:

J Microbiol Biotechnol. 2014 Jun 28;24(6):823-34.

Establishment of Tripterygium wilfordii Hook. f. Hairy root culture and optimization of its culture conditions for the production of triptolide and wilforine.[Pubmed: 24651642]

METHODS AND RESULTS:
In order to solve the shortage of natural Tripterygium wilfordii Hook. f. plant resource for the production of the important secondary metabolites triptolide and wilforine, hairy roots were induced from its root calli by Agrobacterium rhizogenes. Induced hairy roots not only could be maintained and grown well in hormone-free half-strength Murashige and Skoog medium but also could produce sufficient amounts of both triptolide and wilforine. Although hairy roots produced approximately 15% less triptolide than adventitious roots and 10% less wilforine than naturally grown roots, they could grow fast and could be a suitable system for producing both secondary metabolites compared with other tissues. Addition of 50 micrometer methyl jasmonate (MeJA) could slightly affect hairy root growth, but dramatically stimulated the production of both triptolide and wilforine, whereas 50 micrometer salicylic acid had no apparent effect on hairy root growth with slightly stimulatory effects on the production of both secondary metabolites. Addition of precursor nicotinic acid, isoleucine, or aspartic acid at the concentration of 500 micrometer had varying effects on hairy root growth, but none of them had stimulatory effects on triptolide production, and only the former two had slightly beneficial effects on wilforine production. The majority of triptolide produced was secreted into the medium, whereas most of the produced wilforine was retained inside of hairy roots.
CONCLUSIONS:
Our studies provide a promising way to produce triptolide and wilforine in T. wilfordii hairy root cultures combined with MeJA treatment.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
雷公藤宁碱A; Wilfornine A	CFN92120	345954-00-9	C₄₅H₅₁NO₂₀ = 925.9	5mg	QQ客服：1413575084
雷公藤次碱; Wilforine	CFN99207	11088-09-8	C₄₃H₄₉NO₁₈ = 867.9	20mg	QQ客服：3257982914
鬼箭羽碱，叶含卫矛碱; Alatamine	CFN92121	41855-33-8	C₄₁H₄₅NO₁₈ = 839.8	5mg	QQ客服：1413575084
雷公藤定碱; Wilfordine	CFN92103	37239-51-3	C₄₃H₄₉NO₁₉ = 883.9	5mg	QQ客服：1457312923
Peritassine A; Peritassine A	CFN92104	150881-01-9	C₃₈H₄₇NO₁₈ = 805.8	5mg	QQ客服：2056216494
乌木叶碱 E-II; Ebenifoline E-II	CFN92118	133740-16-6	C₄₈H₅₁NO₁₈ = 929.9	5mg	QQ客服：1413575084
Mayteine; Mayteine	CFN92119	104736-05-2	C₄₃H₄₉NO₁₈ = 867.9	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.1522 mL	5.761 mL	11.5221 mL	23.0441 mL	28.8052 mL
5 mM	0.2304 mL	1.1522 mL	2.3044 mL	4.6088 mL	5.761 mL
10 mM	0.1152 mL	0.5761 mL	1.1522 mL	2.3044 mL	2.8805 mL
50 mM	0.023 mL	0.1152 mL	0.2304 mL	0.4609 mL	0.5761 mL
100 mM	0.0115 mL	0.0576 mL	0.1152 mL	0.2304 mL	0.2881 mL