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  • 雷公藤次碱

    Wilforine

    雷公藤次碱
    产品编号 CFN99207
    CAS编号 11088-09-8
    分子式 = 分子量 C43H49NO18 = 867.9
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The vines of Tripterygium wilfordii.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    雷公藤次碱 CFN99207 11088-09-8 10mg QQ客服:2056216494
    雷公藤次碱 CFN99207 11088-09-8 20mg QQ客服:2056216494
    雷公藤次碱 CFN99207 11088-09-8 50mg QQ客服:2056216494
    雷公藤次碱 CFN99207 11088-09-8 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of South Australia (Australia)
  • National Hellenic Research Foundation (Greece)
  • Yale University (USA)
  • Univerzita Karlova v Praze (Czech Republic)
  • St. Jude Children Research Hospital (USA)
  • University of Beira Interior (Portugal)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • Worcester Polytechnic Institute (USA)
  • University of Vienna (Austria)
  • Cornell University (USA)
  • Aarhus University (Denmark)
  • Universidad de Buenos Aires (Argentina)
  • Uniwersytet Jagielloński w Krakowie (Poland)
  • Copenhagen University (Denmark)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Int J Mol Sci.2021, 22(19):10220.
  • Molecules2022, 27(14):4601
  • Int J Mol Sci.2015, 16(1):1232-51
  • Int J Mol Sci.2021, 22(10):5181.
  • Life (Basel).2021, 11(12):1399.
  • Appl. Sci.2020, 10,1304
  • Chem Biol Interact.2020, 328:109200.
  • Biomedicine & Pharmacotherapy2022, 153:113404.
  • Molecules.2022, 27(7):2360.
  • Comparative Clinical Pathology 2021, 30:961-971.
  • Institute of Food Science & Technology2021, 18 December.
  • Molecules.2020, 25(7):1625.
  • Cosmetics2021, 8(3),91.
  • Nutrients.2022, 14(23):4997.
  • Molecules2022, 27(3),1140.
  • Front Pharmacol.2019, 10:1025
  • J Nat Prod.2015, 78(6):1339-4
  • Cell Physiol Biochem.2019, 52(6):1255-1266
  • Nutrients.2018, 10(10)
  • Korean Journal of Plant Resources2021, 34(1):52-58.
  • Industrial Crops and Products2018, 353-362
  • J Phys Chem Lett.2021, 12(7):1793-1802.
  • In Vitro Cellular & Developmental Biology - Plant2022, 58:972-988.
  • ...
  • 生物活性
    Description: Wilforine has anti-inflammatory effect, which might be mediated by down-regulation of the expression of inflammatory factors TNF-α, IL-6 and NO. It also has insecticidal activity by inhibiting the Na+-K+-ATPase in the central nervous system.
    Targets: TNF-α | IL Receptor | NO | ATPase | Sodium channel | Potassium channel
    In vitro:
    J Microbiol Biotechnol. 2014 Jun 28;24(6):823-34.
    Establishment of Tripterygium wilfordii Hook. f. Hairy root culture and optimization of its culture conditions for the production of triptolide and wilforine.[Pubmed: 24651642]

    METHODS AND RESULTS:
    In order to solve the shortage of natural Tripterygium wilfordii Hook. f. plant resource for the production of the important secondary metabolites triptolide and wilforine, hairy roots were induced from its root calli by Agrobacterium rhizogenes. Induced hairy roots not only could be maintained and grown well in hormone-free half-strength Murashige and Skoog medium but also could produce sufficient amounts of both triptolide and wilforine. Although hairy roots produced approximately 15% less triptolide than adventitious roots and 10% less wilforine than naturally grown roots, they could grow fast and could be a suitable system for producing both secondary metabolites compared with other tissues. Addition of 50 micrometer methyl jasmonate (MeJA) could slightly affect hairy root growth, but dramatically stimulated the production of both triptolide and wilforine, whereas 50 micrometer salicylic acid had no apparent effect on hairy root growth with slightly stimulatory effects on the production of both secondary metabolites. Addition of precursor nicotinic acid, isoleucine, or aspartic acid at the concentration of 500 micrometer had varying effects on hairy root growth, but none of them had stimulatory effects on triptolide production, and only the former two had slightly beneficial effects on wilforine production. The majority of triptolide produced was secreted into the medium, whereas most of the produced wilforine was retained inside of hairy roots.
    CONCLUSIONS:
    Our studies provide a promising way to produce triptolide and wilforine in T. wilfordii hairy root cultures combined with MeJA treatment.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.1522 mL 5.761 mL 11.5221 mL 23.0441 mL 28.8052 mL
    5 mM 0.2304 mL 1.1522 mL 2.3044 mL 4.6088 mL 5.761 mL
    10 mM 0.1152 mL 0.5761 mL 1.1522 mL 2.3044 mL 2.8805 mL
    50 mM 0.023 mL 0.1152 mL 0.2304 mL 0.4609 mL 0.5761 mL
    100 mM 0.0115 mL 0.0576 mL 0.1152 mL 0.2304 mL 0.2881 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    雷公藤宁碱A; Wilfornine A CFN92120 345954-00-9 C45H51NO20 = 925.9 5mg QQ客服:2159513211
    雷公藤次碱; Wilforine CFN99207 11088-09-8 C43H49NO18 = 867.9 20mg QQ客服:2056216494
    鬼箭羽碱,叶含卫矛碱; Alatamine CFN92121 41855-33-8 C41H45NO18 = 839.8 5mg QQ客服:1457312923
    雷公藤定碱; Wilfordine CFN92103 37239-51-3 C43H49NO19 = 883.9 5mg QQ客服:2056216494
    Peritassine A; Peritassine A CFN92104 150881-01-9 C38H47NO18 = 805.8 5mg QQ客服:215959384
    乌木叶碱 E-II; Ebenifoline E-II CFN92118 133740-16-6 C48H51NO18 = 929.9 5mg QQ客服:2056216494
    Mayteine; Mayteine CFN92119 104736-05-2 C43H49NO18 = 867.9 5mg QQ客服:1413575084

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