雷公藤次碱
Wilforine
|
|
产品编号 |
CFN99207 |
| CAS编号 |
11088-09-8 |
| 分子式 = 分子量 |
C43H49NO18 = 867.9 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Sesquiterpenoids |
| 植物来源 |
The vines of Tripterygium wilfordii. |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 雷公藤次碱 |
CFN99207 |
11088-09-8 |
10mg |
QQ客服：3004468087 |
| 雷公藤次碱 |
CFN99207 |
11088-09-8 |
20mg |
QQ客服：3004468087 |
| 雷公藤次碱 |
CFN99207 |
11088-09-8 |
50mg |
QQ客服：3004468087 |
| 雷公藤次碱 |
CFN99207 |
11088-09-8 |
100mg |
QQ客服：3004468087 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
Univerzita Karlova v Praze (Czech Republic)
Cancer Research Initatives Foundation(CARIF) (Malaysia)
Charles University in Prague (Czech Republic)
Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
Korea Intitute of Science and Technology (KIST) (Korea)
Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
The Ohio State University (USA)
University of Wisconsin-Madison (USA)
CSIRO - Agriculture Flagship (Australia)
Funda??o Universitária de Desenvolvimento (Brazil)
Universiti Putra Malaysia(UPM) (Malaysia)
Universiti Malaysia Pahang (Malaysia)
China Medical University (Taiwan)
University of Bordeaux (France)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Wilforine has anti-inflammatory effect, which might be mediated by down-regulation of the expression of inflammatory factors TNF-α, IL-6 and NO. It also has insecticidal activity by inhibiting the Na+-K+-ATPase in the central nervous system. |
| Targets: |
TNF-α | IL Receptor | NO | ATPase | Sodium channel | Potassium channel |
| In vitro: |
| J Microbiol Biotechnol. 2014 Jun 28;24(6):823-34. | | Establishment of Tripterygium wilfordii Hook. f. Hairy root culture and optimization of its culture conditions for the production of triptolide and wilforine.[Pubmed: 24651642] |
METHODS AND RESULTS:
In order to solve the shortage of natural Tripterygium wilfordii Hook. f. plant resource for the production of the important secondary metabolites triptolide and wilforine, hairy roots were induced from its root calli by Agrobacterium rhizogenes.
Induced hairy roots not only could be maintained and grown well in hormone-free half-strength Murashige and Skoog medium but also could produce sufficient amounts of both triptolide and wilforine. Although hairy roots produced approximately 15% less triptolide than adventitious roots and 10% less wilforine than naturally grown roots, they could grow fast and could be a suitable system for producing both secondary metabolites compared with other tissues. Addition of 50 micrometer methyl jasmonate (MeJA) could slightly affect hairy root growth, but dramatically stimulated the production of both triptolide and wilforine, whereas 50 micrometer salicylic acid had no apparent effect on hairy root growth with slightly stimulatory effects on the production of both secondary metabolites. Addition of precursor nicotinic acid, isoleucine, or aspartic acid at the concentration of 500 micrometer had varying effects on hairy root growth, but none of them had stimulatory effects on triptolide production, and only the former two had slightly beneficial effects on wilforine production. The majority of triptolide produced was secreted into the medium, whereas most of the produced wilforine was retained inside of hairy roots.
CONCLUSIONS:
Our studies provide a promising way to produce triptolide and wilforine in T. wilfordii hairy root cultures combined with MeJA treatment. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.1522 mL |
5.761 mL |
11.5221 mL |
23.0441 mL |
28.8052 mL |
| 5 mM |
0.2304 mL |
1.1522 mL |
2.3044 mL |
4.6088 mL |
5.761 mL |
| 10 mM |
0.1152 mL |
0.5761 mL |
1.1522 mL |
2.3044 mL |
2.8805 mL |
| 50 mM |
0.023 mL |
0.1152 mL |
0.2304 mL |
0.4609 mL |
0.5761 mL |
| 100 mM |
0.0115 mL |
0.0576 mL |
0.1152 mL |
0.2304 mL |
0.2881 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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