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  • 雷公藤定碱

    Wilfordine

    雷公藤定碱
    产品编号 CFN92103
    CAS编号 37239-51-3
    分子式 = 分子量 C43H49NO19 = 883.9
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The roots of Tripterygium wilfordii Hook. f.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    雷公藤定碱 CFN92103 37239-51-3 1mg QQ客服:2056216494
    雷公藤定碱 CFN92103 37239-51-3 5mg QQ客服:2056216494
    雷公藤定碱 CFN92103 37239-51-3 10mg QQ客服:2056216494
    雷公藤定碱 CFN92103 37239-51-3 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • University of Melbourne (Australia)
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  • Sant Gadge Baba Amravati University (India)
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  • Instituto de Investigaciones Agropecuarias (Chile)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Preprints2022, 202211.0388.v1.
  • Phytomedicine.2019, 67:153159
  • Food Funct.2022, doi: 10.1039
  • Analytical Methods2018, 10(27)
  • Research Square2022, rs.3.rs-1948239
  • J of Advanced Scientific R.2020, 11(3), p109-120.
  • mBio.2020, 11(3):e00686-20.
  • Antioxidants (Basel).2022, 11(12):2327.
  • Molecules.2022, 27(2):451.
  • J Nat Med.2020, 74(1):65-75
  • Int J Biol Macromol.2020, 169:342-351
  • BMC Complement Altern Med.2018, 18(1):303
  • Plants (Basel).2021, 10(7):1376.
  • Pharmacognosy Journal.2022, 14,4,327-337.
  • Asian Journal of Chemistry2018, 30(12):2699-2703
  • In Vitro Cellular & Developmental Biology - Plant 2021, 57:874–882.
  • Hindawi J of Food Biochemistry2023, P17:8883860
  • Int J Mol Sci.2022, 23(10):5813.
  • Biology (Basel).2020, 9(11):363.
  • LWT-Food Sci Technol2020, 109163
  • Anal Bioanal Chem.2020, 412(12):3005-3015.
  • FEBS J.2022, 10.1111:febs.16676.
  • Chin J Pharm Anal.2019, 39(7):1217-1228
  • ...
  • 生物活性
    Description: Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect.
    Targets: Sodium Channel | ATPase | Potassium Channel
    In vivo:
    Chinese Journal of Pesticide Science, 2008, 10(1): 75-9.
    Contact Action of Wilfordine and Wilforine from Tripterygium hypoglaucum and their Effects on Na~+-K~+-ATPase Activities of Mythimna separata[Reference: WebLink]
    Wilfordine and wilforine with contact toxicity against some larvae of insect,were isolated from the insecticidal plants of Tripterygium hypoglaucum.
    METHODS AND RESULTS:
    For investigating their insecticidal mechanism,their poisoning symptoms were observed when wilfordine and wilforine were applied on the pronoturm of Mythimna separata by topical application.The results showed that the larvae were narcotized after 2 hours,revived completely after 8 hours,then narcotized again after 24 hours,part of the larvae were dead after 48 hours.The results also showed that the medium narcosis dose(ND50) of wilfordine and wilforine were 8.82 μg/larva,4.58 μg/larvae against the 3rd instar larvae of M.separata respectively.The ND50 of wilfordine and wilforine were 4.71 μg/larva,3.46 μg/larva against the 3rd instar larvae Plutella xylostella respectively.In vitro and in vivo,the effects of wilfordine and wilforine on Na+-K+-ATPase from the head of the 5th instar larvae of M.separata were investigated.
    CONCLUSIONS:
    The results showed that the Na+-K+-ATPase in the central nervous system was inhibited by wilfordine and wilforine,and the inhibition rate was dependant on the concentration.It suggested that Na+-K+-ATPase may be an acting target of wilfordine and wilforine against some larvae of insect.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.1313 mL 5.6567 mL 11.3135 mL 22.627 mL 28.2837 mL
    5 mM 0.2263 mL 1.1313 mL 2.2627 mL 4.5254 mL 5.6567 mL
    10 mM 0.1131 mL 0.5657 mL 1.1313 mL 2.2627 mL 2.8284 mL
    50 mM 0.0226 mL 0.1131 mL 0.2263 mL 0.4525 mL 0.5657 mL
    100 mM 0.0113 mL 0.0566 mL 0.1131 mL 0.2263 mL 0.2828 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    雷公藤宁碱A; Wilfornine A CFN92120 345954-00-9 C45H51NO20 = 925.9 5mg QQ客服:1413575084
    雷公藤次碱; Wilforine CFN99207 11088-09-8 C43H49NO18 = 867.9 20mg QQ客服:215959384
    鬼箭羽碱,叶含卫矛碱; Alatamine CFN92121 41855-33-8 C41H45NO18 = 839.8 5mg QQ客服:215959384
    雷公藤定碱; Wilfordine CFN92103 37239-51-3 C43H49NO19 = 883.9 5mg QQ客服:215959384
    Peritassine A; Peritassine A CFN92104 150881-01-9 C38H47NO18 = 805.8 5mg QQ客服:1413575084
    乌木叶碱 E-II; Ebenifoline E-II CFN92118 133740-16-6 C48H51NO18 = 929.9 5mg QQ客服:2056216494
    Mayteine; Mayteine CFN92119 104736-05-2 C43H49NO18 = 867.9 5mg QQ客服:2056216494

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