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  • 新橙皮苷

    Neohesperidin

    新橙皮苷
    产品编号 CFN99125
    CAS编号 13241-33-3
    分子式 = 分子量 C28H34O15 = 610.56
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The peels of Citrus aurantium L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    新橙皮苷 CFN99125 13241-33-3 10mg QQ客服:2056216494
    新橙皮苷 CFN99125 13241-33-3 20mg QQ客服:2056216494
    新橙皮苷 CFN99125 13241-33-3 50mg QQ客服:2056216494
    新橙皮苷 CFN99125 13241-33-3 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Cincinnati (USA)
  • University of Wollongong (Australia)
  • Washington State University (USA)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Mahidol University (Thailand)
  • Universidad Miguel Hernández (Spain)
  • Kazusa DNA Research Institute (Japan)
  • National Cancer Center Research Institute (Japan)
  • Subang Jaya Medical Centre (Malaysia)
  • Julius Kühn-Institut (Germany)
  • Massachusetts General Hospital (USA)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Michigan State University (USA)
  • University of Maryland (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Mol Recognit.2020, 33(2):e2819
  • Mol Pharmacol.2021, 99(2):163-174.
  • J Biochem Mol Toxicol.2017, 31(9)
  • Molecules.2021, 26(4):1084.
  • Nutrients.2021, 13(3):978.
  • Vietnam Journal of Food Control.2022, 5(3):pp.488-497.
  • Food Research2021, 5(1):65-71
  • Antioxidants.2022, 11(4), 67.
  • Food Chem.2021, 337:128023.
  • Chem Biol Interact.2018, 290:44-51
  • Food Chem Toxicol.2023, 176:113785.
  • Phytomedicine.2019, 57:95-104
  • Acta Agriculturae Scandinavica2015, 381-383
  • JPC-Journal of Planar Chromatography 2017, 30(2)
  • Phytomedicine.2018, 47:48-57
  • Front Pharmacol.2019, 10:1355
  • Mol Cell.2017, 68(4):673-685
  • Nat Prod Sci.2019, 25(3):238
  • FASEB J.2019, 33(2):2026-2036
  • AMB Express2020. 10(1):126.
  • Korean J of Medicinal Crop Science2018, 220-226
  • Sci Rep.2018, 8:15059
  • Tea Res. Ins. Of China2017, 1-12
  • ...
  • 生物活性
    Description: Neohesperidin, a natural new nutrition sweetener, has antioxidant (IC50=22.31ug/mL), anti-inflammatory, and neuroprotective effects. It can attenuate cerebral ischemia-reperfusion injury via the inhibition of neuronal and oxidative stress through the regulation of the apoptotic pathway and activating the Akt/Nrf2/HO-1 pathway, it may be useful for the treatment and/or protection of gastritis.
    Targets: Beta Amyloid | ROS | Calcium Channel | HO-1 | Nrf2 | Akt | Caspase | Bcl-2/Bax | TNF-α | COX
    In vitro:
    Curr Alzheimer Res. 2015;12(5):424-33.
    Inhibition of β-amyloid Aggregation By Albiflorin, Aloeemodin And Neohesperidin And Their Neuroprotective Effect On Primary Hippocampal Cells Against β-amyloid Induced Toxicity.[Pubmed: 25938872]
    Being one of the hallmarks of Alzheimer's disease, β-amyloid (Aβ) aggregates induce complicated neurotoxicity. Evidences show that the underlying mechanism of neurotoxicity involves a glutamate receptor subtype, N-methyl-D-aspartate (NMDA) receptor, an increase in intracellular calcium(II) ion loading as well as an elevation in oxidation stress.
    METHODS AND RESULTS:
    In this work, among the 35 chemical components of Chinese herbal medicines (CHMs) being screened for inhibitors of Aβ aggregation, four of them, namely albiflorin, aloeemodin, neohesperidin and physcion, were found for the first time to exhibit a potent inhibitory effect on Aβ(1-40) and Aβ(1-42) aggregation. Their neuroprotective capability on primary hippocampal neuronal cells was also investigated by MTT assay, ROS assay and intracellular calcium(II) ion concentration measurement.
    CONCLUSIONS:
    It was interesting to find that physcion was rather toxic to neuronal cells while albiflorin, aloeemodin and neohesperidin reduced the toxicity and ROS induced by both monomeric and oligomeric Aβ species. In addition, albiflorin was particularly powerful in maintaining the intracellular Ca(2+) concentration.
    In vivo:
    J Asian Nat Prod Res. 2013 Sep;15(9):1023-37.
    Neohesperidin attenuates cerebral ischemia-reperfusion injury via inhibiting the apoptotic pathway and activating the Akt/Nrf2/HO-1 pathway.[Pubmed: 23952707]
    Oxidative stress is well known to play a pivotal role in cerebral ischemia-reperfusion injury. On the basis of this fact, antioxidative agents have been demonstrated to be neuroprotective. Neohesperidin (NH) is abundant in citrus flavonoids and possesses reactive oxygen species scavenging activity and neuroprotective effects in vitro. However, little is known about its effects on cerebral ischemia-reperfusion injury and the underlying mechanisms.
    METHODS AND RESULTS:
    In this study, we use a rat model of middle cerebral artery occlusion (MCAO) to investigate the neuroprotective effects of NH. NH significantly improved neurological functions and attenuated MCAO-induced infarct volume, pathological changes, and neuronal loss. Moreover, it enhanced antioxidant capacity and suppressed oxidative stress in the brain. NH inhibited the MCAO-induced upregulation of Bax, cytochrome c, and cleaved caspase-9 and -3, as well as the downregulation of Bcl-2. Interestingly, NH treatment upregulated heme oxygenase-1 (HO-1) in a concentration-dependent manner, which was due to the NH-mediated activation of the protein kinase B (Akt)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. NH also abolished the MCAO-induced inhibition of the Akt/Nrf2 pathway.
    CONCLUSIONS:
    In conclusion, NH attenuates cerebral ischemia-reperfusion injury via the inhibition of neuronal apoptosis and oxidative stress through the regulation of the apoptotic pathway and the Akt/Nrf2/HO-1 pathway. NH might be a promising preventive agent for ischemic stroke.
    Phytother Res. 2009 Dec;23(12):1748-53
    Protective effects of neohesperidin and poncirin isolated from the fruits of Poncirus trifoliata on potential gastric disease.[Pubmed: 19367677]

    METHODS AND RESULTS:
    The effects of Poncirus trifoliata (P. trifoliata) (Ponciri Fructus, PF) extract and its constituents such as neohesperidin and poncirin on gastritis in rats and human gastric cancer cells were investigated. The PF 70% ethanol extracts (1 g) showed approximately 11.38% of acid-neutralizing capacities and cytotoxicity (IC50=85.39 microg/mL) against human AGS gastric cancer cells. In addition, neohesperidin exhibited antioxidant activity (IC50=22.31 microg/mL) in the 1,1-diphenyl-2-picryldydrazyl (DPPH) radical-scavenging assay. Neohesperidin (50 mg/kg) and poncirin (100 mg/kg) significantly inhibited 55.0% and 60.0% of HCl/ethanol-induced gastric lesions, respectively, and increased the mucus content. In pylorus ligated rats, neohesperidin (50 mg/kg) significantly decreased the volume of gastric secretion and gastric acid output, and increased the pH.
    METHODS AND RESULTS:
    From these results, it could be suggested that neohesperidin and poncirin isolated from PF may be useful for the treatment and/or protection of gastritis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6378 mL 8.1892 mL 16.3784 mL 32.7568 mL 40.946 mL
    5 mM 0.3276 mL 1.6378 mL 3.2757 mL 6.5514 mL 8.1892 mL
    10 mM 0.1638 mL 0.8189 mL 1.6378 mL 3.2757 mL 4.0946 mL
    50 mM 0.0328 mL 0.1638 mL 0.3276 mL 0.6551 mL 0.8189 mL
    100 mM 0.0164 mL 0.0819 mL 0.1638 mL 0.3276 mL 0.4095 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3''-O-咖啡酰橙皮苷; 3''-O-Caffeoylhesperidin CFN95564 N/A C37H40O18 = 772.7 5mg QQ客服:2159513211
    橙皮素5-O-葡萄糖苷; Hesperetin 5-O-glucoside CFN96023 69651-80-5 C22H24O11 = 464.4 5mg QQ客服:3257982914
    桃苷; Persicoside CFN97908 28978-03-2 C23H26O11 = 478.5 5mg QQ客服:1457312923
    甲基橙皮甙; 甲基橙皮苷; Methyl hesperidin CFN99584 11013-97-1 C29H36O15 = 624.59 20mg QQ客服:2056216494
    地奥司明杂质8; Diosmin Impurity 8 CFN95309 28719-21-3 C30H38O15 = 638.6 10mg QQ客服:2159513211
    (R)-5,3'-二甲基橙皮苷; (R)-5,3'-Dimethyl hesperidin CFN95310 N/A C30H38O15 = 638.6 5mg QQ客服:1413575084
    新橙皮苷; Neohesperidin CFN99125 13241-33-3 C28H34O15 = 610.56 20mg QQ客服:215959384
    圣草酚-8-葡萄糖苷; Eriodictyol-8-glucoside CFN91942 153733-96-1 C21H22O11 = 450.39 5mg QQ客服:2056216494
    (R)-圣草酚-8-C-beta-D-葡萄糖苷; (R)-Eriodictyol-8-C-beta-D-glucopyranoside CFN91943 1023271-51-3 C21H22O11 = 450.39 5mg QQ客服:1457312923
    Beta-D-glucopyranosiduronic acid; Beta-D-glucopyranosiduronic acid CFN92281 60092-34-4 C21H20O11 = 448.4 5mg QQ客服:2056216494

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