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  • 甲基橙皮甙; 甲基橙皮苷

    Methyl hesperidin

    甲基橙皮甙; 甲基橙皮苷
    产品编号 CFN99584
    CAS编号 11013-97-1
    分子式 = 分子量 C29H36O15 = 624.59
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Hypericurn monogynum L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    甲基橙皮甙; 甲基橙皮苷 CFN99584 11013-97-1 10mg QQ客服:2159513211
    甲基橙皮甙; 甲基橙皮苷 CFN99584 11013-97-1 20mg QQ客服:2159513211
    甲基橙皮甙; 甲基橙皮苷 CFN99584 11013-97-1 50mg QQ客服:2159513211
    甲基橙皮甙; 甲基橙皮苷 CFN99584 11013-97-1 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • National Chung Hsing University (Taiwan)
  • Texas A&M University (USA)
  • National Research Council of Canada (Canada)
  • Universidade de Franca (Brazil)
  • Universite de Lille1 (France)
  • Chulalongkorn University (Thailand)
  • VIT University (India)
  • Kyung Hee University (Korea)
  • Chinese University of Hong Kong (China)
  • Lodz University of Technology (Poland)
  • University of Bordeaux (France)
  • University of Medicine and Pharmacy (Romania)
  • The Institute of Cancer Research (United Kingdom)
  • Wroclaw Medical University (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Asian J of Pharmaceutical&Clinical 2018, 11(2)
  • Antioxidants (Basel).2020, 9(6):466.
  • British Jou. Med.&Med. Research2014, 1802-1811
  • Chinese Medicine2019, 14(1)
  • Front Pharmacol.2019, 10:1025
  • Org Biomol Chem.2017, 15(31):6483-6492
  • Agriculture.2022, 12(3), 342.
  • J of Physics Conference Series2019, 1349(1)
  • Appl. Sci. 2021, 11(10),4666.
  • J Food Sci.2022, 87(11):4905-4916.
  • Forensic Sci Int.2022, 341:111475.
  • Molecules.2021, 26(2):313.
  • Applied Biological Chemistry2022, 65(85).
  • Korean J. Medicinal Crop Sci.2021, 29(1):45-50.
  • Molecules.2021, 26(6):1738.
  • Journal of Oil Palm Research2019, 31(2):238-247
  • Bioorg Med Chem.2020, 28(12):115553.
  • Acta Physiologiae Plantarum2015, 37:1736
  • In Vitro Cellular & Developmental Biology - Plant 2021, 57:874–882.
  • Front Immunol.2017, 8:1542
  • BMC Cancer. 2021, 21(1):91.
  • Nutrients.2023, 15(4):954.
  • Drug Invention Today2019, 12(6):1303-1306
  • ...
  • 生物活性
    Description: Methyl hesperidin has potentiating effect on coronary vasodilation induced by adenosine or related compounds, It caused inhibition of nitrendipine transport in the ileum and jejunum, but not in the duodenum. Methyl hesperidin exerts no obvious toxic effects in mice of either sex when administered at a level as high as 5.0% in the diet.
    In vitro:
    Drug Metabol Drug Interact. 2008;23(3-4):299-310.
    Influence of some bioflavonoids on the transport of nitrendipine.[Pubmed: 19326773]
    Flavonoids form a large class of phenolic substances widely distributed in nature and exhibit several biological effects. P-glycoprotein is part of a large family of efflux transporters found in the gut, gonads and other organs.
    METHODS AND RESULTS:
    Male albino rats were used for this study. The whole small intestine was flushed with 50 ml of ice-cold saline after sacrificing the animal with an overdose of pentobarbital. The small intestine was isolated and divided into duodenum, jejunum and ileum. Each segment was everted, a 5-cm long sac was prepared, 1 ml of nitrendipine solution was introduced into the everted sac (serosal side), and both ends of the sac were ligated tightly. The sac containing nitrendipine solution was immersed in 30 ml of Dulbecco's phosphate buffer solution (D-PBS) containing 25 mM glucose and the same concentration of different bioflavonoids, viz., diosmin, quercetin, chrysin, methyl hesperidin and gossypin, was introduced into the mucosal side. Transport of nitrendipine from serosal to mucosal surfaces across the intestine was determined by collecting samples from the mucosal medium periodically at different intervals: 0, 10, 20, 30, 60, 90 and 120 minutes. The samples were analyzed by HPLC. Diosmin and quercetin decreased the transport rate of nitrendipine to nearly the same extent in all regions. Chrysin and gossypin decreased the transport rate of nitrendipine to a greater extent in the ileum than in the duodenum and jejunum. Methyl hesperidin caused inhibition of nitrendipine transport in the ileum and jejunum, but not in the duodenum.
    CONCLUSIONS:
    All bioflavonoids, i.e., quercetin, diosmin, methyl hesperidin, gossypin and chrysin, decreased the transport of nitrendipine, a P-gp substrate in the rat intestine. The highest expression of P-gp was found in the ileum followed by the jejunum and duodenum.
    In vivo:
    Food Chem Toxicol. 1990 Sep;28(9):613-8.
    Carcinogenicity study of methyl hesperidin in B6C3F1 mice.[Pubmed: 2272558]

    METHODS AND RESULTS:
    A long-term carcinogenicity study of methyl hesperidin, a compound of the vitamin P group, was carried out in B6C3F1 mice receiving dietary concentrations of 0, 1.25 or 5%. Administration was continued for 96 wk and then the mice were maintained on basal diet for an additional 8 wk. Growth retardation during the experiment with final changes in organ weights were observed in females given the 1.25% dose of methyl hesperidin and in both sexes receiving the 5.0% treatment. However, no biologically significant effects were evident with respect to mortality or clinical signs. Furthermore, treatment with methyl hesperidin did not result in any changes in haematology, clinical chemistry and urinalysis data. On histological examination, no significant alteration of non-neoplastic and neoplastic lesion incidence was observed in treated mice.
    CONCLUSIONS:
    The results thus demonstrated that methyl hesperidin lacked any carcinogenicity for B6C3F1 mice in the 96-wk feeding regimen used in this study.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6011 mL 8.0053 mL 16.0105 mL 32.021 mL 40.0263 mL
    5 mM 0.3202 mL 1.6011 mL 3.2021 mL 6.4042 mL 8.0053 mL
    10 mM 0.1601 mL 0.8005 mL 1.6011 mL 3.2021 mL 4.0026 mL
    50 mM 0.032 mL 0.1601 mL 0.3202 mL 0.6404 mL 0.8005 mL
    100 mM 0.016 mL 0.0801 mL 0.1601 mL 0.3202 mL 0.4003 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    新北美圣草苷; Neoeriocitrin CFN92304 13241-32-2 C27H32O15 = 596.5 20mg QQ客服:2159513211
    圣草次甙; 圣草次苷; Eriocitrin CFN99718 13463-28-0 C27H32O15 = 596.53 20mg QQ客服:2056216494
    橙皮素7-O-葡萄糖苷; Hesperetin 7-O-glucoside CFN98405 31712-49-9 C22H24O11 = 464.4 10mg QQ客服:2056216494
    橙皮苷; Hesperidin CFN98839 520-26-3 C28H34O15 = 610.6 20mg QQ客服:215959384
    3''-O-咖啡酰橙皮苷; 3''-O-Caffeoylhesperidin CFN95564 N/A C37H40O18 = 772.7 5mg QQ客服:2056216494
    橙皮素5-O-葡萄糖苷; Hesperetin 5-O-glucoside CFN96023 69651-80-5 C22H24O11 = 464.4 5mg QQ客服:1413575084
    桃苷; Persicoside CFN97908 28978-03-2 C23H26O11 = 478.5 5mg QQ客服:1457312923
    甲基橙皮甙; 甲基橙皮苷; Methyl hesperidin CFN99584 11013-97-1 C29H36O15 = 624.59 20mg QQ客服:1413575084
    地奥司明杂质8; Diosmin Impurity 8 CFN95309 28719-21-3 C30H38O15 = 638.6 10mg QQ客服:1413575084
    (R)-5,3'-二甲基橙皮苷; (R)-5,3'-Dimethyl hesperidin CFN95310 N/A C30H38O15 = 638.6 5mg QQ客服:3257982914

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