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  • 圣草次甙; 圣草次苷

    Eriocitrin

    圣草次甙; 圣草次苷
    产品编号 CFN99718
    CAS编号 13463-28-0
    分子式 = 分子量 C27H32O15 = 596.53
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The fruits of Citrus sinensis (L.) Osbeck
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    圣草次甙; 圣草次苷 CFN99718 13463-28-0 10mg QQ客服:215959384
    圣草次甙; 圣草次苷 CFN99718 13463-28-0 20mg QQ客服:215959384
    圣草次甙; 圣草次苷 CFN99718 13463-28-0 50mg QQ客服:215959384
    圣草次甙; 圣草次苷 CFN99718 13463-28-0 100mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Illinois (USA)
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  • Florida International University (USA)
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  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Science&Tech. Res.2022, 28(2):123-132.
  • J of the Korean Society of Cosmetics and Cosmetology2018, 399-406
  • Cell Prolif.2021, 54(8):e13083.
  • Drug Dev Res.2020, doi: 10.1002
  • Agronomy2020, 10(3),388.
  • Evid Based Complement Alternat Med.2016, 2016:1230294
  • Theoretical and Experimental Plant Physiology 2022, 34,53-62
  • Molecules.2020, 25(18):4283.
  • Korean Journal of Medicinal Crop Science2018, 26(5):382-390
  • Korean J. Medicinal Crop Sci.2021, 29(6):425-433
  • J of Health Science and Alternative Medicine2019, 1(1)
  • Korean J Environ Agric.2018, 37(4):260-267
  • Anticancer Res.2014, 34(7):3505-9
  • The Journal of Animal & Plant Sciences.2020, 30(6):1366-1373
  • J Nat Med.2021, doi: 10.1007.
  • Plant Archives2020, 2(1),2929-2934
  • J Biochem Mol Toxicol.2017, 31(9)
  • Drug Chem Toxicol.2020, 1-14.
  • J Ethnopharmacol.2020, 249:112381
  • Food Sci Biotechnol.2021, 30(2):217-226.
  • BMC Complement Altern Med.2016, 16:213
  • Food Chem.2022, 378:131975.
  • South African J of Plant&Soil2018, 29-32
  • ...
  • 生物活性
    Description: Eriocitrin is powerful antioxidative flavonoid, it can prevent oxidative damages caused by acute exercise-induced oxidative stress, it also has lipid-lowering effect in rats on a high-fat and high-cholesterol diet. Eriocitrin is a potent inhibitor of human carbonic anhydrase VA isozyme.
    Targets: LDL | ATP synthase
    In vitro:
    J. Food Sci., 2006, 71(71):S633–S7.
    Lipid-Lowering Effect of Eriocitrin, the Main Flavonoid in Lemon Fruit, in Rats on a High-Fat and High-Cholesterol Diet[Reference: WebLink]
    Eriocitrin (eriodictyol 7-O-β-rutinoside) is the main flavonoid in lemon fruit.
    METHODS AND RESULTS:
    In this study, Eriocitrin was investigated for its lowering effect on serum and hepatic lipids in high-fat and high-cholesterol fed rats. Rats in the control group (N = 6) were fed a 20% lard and 1% cholesterol diet for 21 d, and rats in the 0.35% Eriocitrin group (N = 6) and 0.70% Eriocitrin group (N = 6) were fed a diet supplemented with Eriocitrin 0.35% and 0.70%, respectively. The content of hepatic total cholesterol and triglyceride in the Eriocitrin group was no different from that of the control group. The total cholesterol, VLDL+LDL, triglyceride, and phospholipid in the serum of the 0.35% Eriocitrin group showed significantly lower concentrations than the control group (P < 0.05), although there was no difference in the HDL concentrations among the groups. The lowering effect of Eriocitrin for serum total cholesterol was thought to be caused by a decrease in VLDL+LDL.
    CONCLUSIONS:
    The 0.35% Eriocitrin group was shown to have a significant increase in excretion of fecal bile acid (P < 0.05) and a tendency for enhanced hepatic m-RNA levels of LDL receptor in comparison with the control group.
    Cancer Chemother Pharmacol . 2016 Dec;78(6):1143-1150.
    Eriocitrin from lemon suppresses the proliferation of human hepatocellular carcinoma cells through inducing apoptosis and arresting cell cycle[Pubmed: 27766389]
    Abstract Hepatocellular carcinoma is a lethal cancer with high recurrence ratio and lacks effective therapeutics. In the past few years, it has been reported that increased intake of vegetables and fruits could reduce the cancer incidence, which suggests dietary agents might possess anticancer effects. Eriocitrin is a flavonoid isolated from lemon, which is known as a strong antioxidant agent. We here for the first time demonstrated that eriocitrin could inhibit the proliferation of hepatocellular carcinoma cell lines by arresting cell cycle in S phase through up-regulation of p53, cyclin A, cyclin D3 and CDK6. Furthermore, we found that eriocitrin could trigger apoptosis by activating mitochondria-involved intrinsic signaling pathway. Thus, eriocitrin might be regarded as a potential chemopreventive natural product to inhibit the early malignant transformation of hepatocellular carcinoma. Keywords: Apoptosis; Cell cycle arrest; Eriocitrin; Hepatocellular carcinoma.
    In vivo:
    Sci Rep. 2014 Jan 15;4:3708.
    Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis.[Pubmed: 24424211]
    Lemon (Citrus limon) contains various bioactive flavonoids, and prevents obesity and obesity-associated metabolic diseases. We focused on eriocitrin (eriodictyol 7-rutinoside), a powerful antioxidative flavonoid in lemon with lipid-lowering effects in a rat model of high-fat diet.
    METHODS AND RESULTS:
    To investigate the mechanism of action of eriocitrin, we conducted feeding experiments on zebrafish with diet-induced obesity. Oral administration of eriocitrin (32 mg/kg/day for 28 days) improved dyslipidaemia and decreased lipid droplets in the liver. DNA microarray analysis revealed that eriocitrin increased mRNA of mitochondrial biogenesis genes, such as mitochondria transcription factor, nuclear respiratory factor 1, cytochrome c oxidase subunit 4, and ATP synthase. In HepG2 cells, eriocitrin also induced the corresponding orthologues, and reduced lipid accumulation under conditions of lipid loading. Eriocitrin increased mitochondrial size and mtDNA content, which resulted in ATP production in HepG2 cells and zebrafish.
    CONCLUSIONS:
    In summary, dietary eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis.
    J Agric Food Chem. 2000 Aug;48(8):3217-24.
    Identification and antioxidant activity of flavonoid metabolites in plasma and urine of eriocitrin-treated rats.[Pubmed: 10956094]
    Eriocitrin, a flavonoid glycoside present in lemon fruit, is metabolized in vivo to a series of eriodictyol, methylated eriodictyol, 3,4-dihydroxyhydrocinnamic acid, and their conjugates.
    METHODS AND RESULTS:
    Plasma antioxidant activity increased following oral administration of aqueous Eriocitrin solutions to rats. Eriocitrin metabolites were found in plasma and renal excreted urine through HPLC and LC-MS analyses. Eriocitrin was not detected in plasma and urine, but eriodictyol, homoeriodictyol, and hesperetin in their conjugated forms were detected in plasma of 4.0 h following administration of Eriocitrin. In urine for 24 h, both nonconjugates and conjugates of these metabolites were detected. 3,4-Dihydroxyhydrocinnamic acid, which is metabolized from eriodictyol by intestinal bacteria, was detected in slight amounts with each form in 4.0-h plasma and 24-h urine. Eriocitrin was suggested to be metabolized by intestinal bacteria, and then eriodictyol and 3,4-dihydroxyhydrocinnamic of its metabolite were absorbed.
    CONCLUSIONS:
    Following administration of Eriocitrin, plasma exhibited an elevated resistance effect to lipid peroxidation. Eriocitrin metabolites functioning as antioxidant agents are discussed.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.6764 mL 8.3818 mL 16.7636 mL 33.5272 mL 41.909 mL
    5 mM 0.3353 mL 1.6764 mL 3.3527 mL 6.7054 mL 8.3818 mL
    10 mM 0.1676 mL 0.8382 mL 1.6764 mL 3.3527 mL 4.1909 mL
    50 mM 0.0335 mL 0.1676 mL 0.3353 mL 0.6705 mL 0.8382 mL
    100 mM 0.0168 mL 0.0838 mL 0.1676 mL 0.3353 mL 0.4191 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    圣草酚-8-葡萄糖苷; Eriodictyol-8-glucoside CFN91942 153733-96-1 C21H22O11 = 450.39 5mg QQ客服:1457312923
    (R)-圣草酚-8-C-beta-D-葡萄糖苷; (R)-Eriodictyol-8-C-beta-D-glucopyranoside CFN91943 1023271-51-3 C21H22O11 = 450.39 5mg QQ客服:2159513211
    Beta-D-glucopyranosiduronic acid; Beta-D-glucopyranosiduronic acid CFN92281 60092-34-4 C21H20O11 = 448.4 5mg QQ客服:2159513211
    圣草酚-7-O-葡萄糖苷; Eriodictyol-7-O-glucoside CFN97865 38965-51-4 C21H22O11 = 450.39 10mg QQ客服:215959384
    圣草酚-7-O-葡萄糖醛酸苷; Eriodictyol 7-O-glucuronide CFN95290 125535-06-0 C21H20O12 = 464.4 10mg QQ客服:1413575084
    高圣草素-7-O-β-D-葡萄糖苷; Homoeriodictyol 7-O-glucoside CFN89463 14982-11-7 C22H24O11 = 464.41 5mg QQ客服:1413575084
    新北美圣草苷; Neoeriocitrin CFN92304 13241-32-2 C27H32O15 = 596.5 20mg QQ客服:1413575084
    圣草次甙; 圣草次苷; Eriocitrin CFN99718 13463-28-0 C27H32O15 = 596.53 20mg QQ客服:2056216494
    橙皮素7-O-葡萄糖苷; Hesperetin 7-O-glucoside CFN98405 31712-49-9 C22H24O11 = 464.4 10mg QQ客服:3257982914
    橙皮苷; Hesperidin CFN98839 520-26-3 C28H34O15 = 610.6 20mg QQ客服:1457312923

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