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  • 木犀草素 7-芸香糖苷

    Luteolin 7-rutinoside

    木犀草素 7-芸香糖苷
    产品编号 CFN93556
    CAS编号 20633-84-5
    分子式 = 分子量 C27H30O15 = 594.52
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The whole plants of Artemisia montana.
    产品名称 产品编号 CAS编号 包装 QQ客服
    木犀草素 7-芸香糖苷 CFN93556 20633-84-5 1mg QQ客服:215959384
    木犀草素 7-芸香糖苷 CFN93556 20633-84-5 5mg QQ客服:215959384
    木犀草素 7-芸香糖苷 CFN93556 20633-84-5 10mg QQ客服:215959384
    木犀草素 7-芸香糖苷 CFN93556 20633-84-5 20mg QQ客服:215959384
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
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    Nature Plants. 2016 Dec 22;3: 16206.
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    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • University of Illinois at Chicago (USA)
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  • Universidad Miguel Hernández (Spain)
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  • Donald Danforth Plant Science Center (USA)
  • Utrecht University (Netherlands)
  • Complutense University of Madrid (Spain)
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  • ...
  • 生物活性
    Description: Luteolin 7-rutinoside has antiallergic, antimicrobial, antimutagenic and radical scavenging activities, it showed antimutagenic effects on TA1537 and TA1535 strains. Luteolin 7-rutinoside also displayed potent rat lens aldose reductase inhibitory activities with IC(50) values ranging from 0.19 to 5.37 μM.
    Targets: Aldose reductase | Antifection
    In vitro:
    Food Chem. 2012 Nov 15;135(2):764-9.
    Isolation of some luteolin derivatives from Mentha longifolia (L.) Hudson subsp. longifolia and determination of their genotoxic potencies.[Pubmed: 22868156 ]
    This study was designed to evaluate the mutagenic and antimutagenic activities of luteolin derivatives (luteolin 7-O-glucoside, luteolin 7-O-rutinoside and luteolin 7-O-glucuronide) isolated from Mentha longifolia (L.) Huds. subsp. longifolia by using Ames Salmonella test (TA 1535 and TA1537 strains).
    In the antimutagenicity assays, luteolin 7-O-glucoside, luteolin 7-O-rutinoside(Luteolin 7-rutinoside) and luteolin 7-O-glucuronide showed antimutagenic effects on TA1537 and TA1535 strains. The highest inhibition rates for luteolin 7-O-glucoside, luteolin 7-O-rutinoside and luteolin 7-O-glucuronide on TA1537 strain were 84.03%, 87.63% and 67.77%, respectively. Similarly, in the antimutagenicity assays performed with the TA1535 strain, the inhibition rates for luteolin 7-O-glucoside and luteolin 7-O-rutinoside(Luteolin 7-rutinoside) were 23.86% and 23.76% respectively.
    Our findings showed that the antimutagenic properties of luteolin derivatives on TA1537 and TA1535 strains have been found to be structure dependent. The clarification of differences in antimutagenic potency of these luteolin derivatives based on their structures has been demonstrated in this study.
    J Agric Food Chem. 2004 Dec 1;52(24):7272-8.
    Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities.[Pubmed: 15563206 ]

    A preliminary antimicrobial disk assay of chloroform, ethyl acetate, and n-butanol extracts of artichoke (Cynara scolymus L.) leaf extracts showed that the n-butanol fraction exhibited the most significant antimicrobial activities against seven bacteria species, four yeasts, and four molds. Eight phenolic compounds were isolated from the n-butanol soluble fraction of artichoke leaf extracts. On the basis of high-performance liquid chromatography/electrospray ionization mass spectrometry, tandem mass spectrometry, and nuclear magnetic resonance techniques, the structures of the isolated compounds were determined as the four caffeoylquinic acid derivatives, chlorogenic acid (1), cynarin (2), 3,5-di-O-caffeoylquinic acid (3), and 4,5-di-O-caffeoylquinic acid (4), and the four flavonoids, luteolin 7-rutinoside (5), cynaroside (6), apigenin-7-rutinoside (7), and apigenin-7-O-beta-D-glucopyranoside (8), respectively.
    The isolated compounds were examined for their antimicrobial activities on the above microorganisms, indicating that all eight phenolic compounds showed activity against most of the tested organisms. Among them, chlorogenic acid, cynarin, luteolin-7-rutinoside, and cynaroside exhibited a relatively higher activity than other compounds; in addition, they were more effective against fungi than bacteria. The minimum inhibitory concentrations of these compounds were between 50 and 200 microg/mL.
    Molecules. 2009 Jan 22;14(1):509-18.
    Antimutagenic activity and radical scavenging activity of water infusions and phenolics from ligustrum plants leaves.[Pubmed: 19169198 ]
    Water infusions of Ligustrum delavayanum and Ligustrum vulgare leaves and eight phenolics isolated therefrom have been assayed in vitro on ofloxacin-induced genotoxicity in the unicellular flagellate Euglena gracilis.
    The tested compounds luteolin, quercetin, luteolin-7-glucoside, luteolin 7-rutinoside, quercetin-3-rutinoside, apigenin-7-rutinoside, tyrosol and esculetin inhibited the mutagenic activity of ofloxacin (43 microM) in E. gracilis. Water infusions from leaves of L. delavayanum and L. vulgare showed higher antimutagenic effect (p(t) < 0.001). The activity of these samples against ofloxacin (86 microM)-induced genotoxicity was lower, but statistically significant (p(t) < 0.05), excluding the water infusion of L. delavayanum leaves (p(t) < 0.01). Efficacy of quercetin, luteolin-7-rutinoside, apigenin-7-rutinoside was insignificant.
    The antimutagenic effect of most phenolics we studied could be clearly ascribed to their DPPH scavenging activity, substitution patterns and lipophilicity.
    Biol Pharm Bull. 2002 Feb;25(2):256-9.
    Antiallergic effect of flavonoid glycosides obtained from Mentha piperita L.[Pubmed: 11853178 ]

    Six flavonoid glycosides, eriocitrin (1), narirutin (2), hesperidin (3), luteolin-7-O-rutinoside (Luteolin 7-rutinoside,4), isorhoifolin (5), diosmin (6), rosmarinic acid (7) and 5,7-dihydroxycromone-7-O-rutinoside (8), were isolated from the aerial part of Mentha piperita L. Among these compounds, compound 4 showed a potent inhibitory effect on histamine release induced by compound 48/80 and antigen-antibody reaction. This compound was more effective than luteolin and luteolin-7-O-glucoside in inhibiting histamine release from rat peritoneal mast cells. Compound 4 also caused a dose-related inhibition of the antigen-induced nasal response and significant effects were observed at doses of 100 and 300 mg/kg.
    These results indicate that compound 4 may be clinically useful in alleviating the nasal symptoms of allergic rhinitis.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.682 mL 8.4101 mL 16.8203 mL 33.6406 mL 42.0507 mL
    5 mM 0.3364 mL 1.682 mL 3.3641 mL 6.7281 mL 8.4101 mL
    10 mM 0.1682 mL 0.841 mL 1.682 mL 3.3641 mL 4.2051 mL
    50 mM 0.0336 mL 0.1682 mL 0.3364 mL 0.6728 mL 0.841 mL
    100 mM 0.0168 mL 0.0841 mL 0.1682 mL 0.3364 mL 0.4205 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    万寿菊苷; Patulitrin CFN95153 19833-25-1 C22H22O13 = 494.4 5mg QQ客服:2159513211
    柯伊利素-7-O-葡萄糖苷; Chrysoeriol-7-O-glucoside CFN93021 19993-32-9 C22H22O11 = 462.4 5mg QQ客服:2159513211
    香叶木素7-O-beta-D-葡萄糖苷; Diosmetin-7-O-beta-D-glucopyranoside CFN98502 20126-59-4 C22H22O11 = 462.41 20mg QQ客服:1148253675
    地奥司明; Diosmin CFN98145 520-27-4 C28H32O15 = 608.54 20mg QQ客服:215959384
    新地奥司明; Neodiosmin CFN93075 38665-01-9 C28H32O15 = 608.54 20mg QQ客服:1413575084
    Lethedoside A; Lethedoside A CFN98100 221289-20-9 C24H26O11 = 490.5 5mg QQ客服:2159513211
    Lethedioside A; Lethedioside A CFN98201 221289-31-2 C29H34O15 = 622.6 5mg QQ客服:3257982914
    5-羟基-7,8,2',5'-四甲氧基黄酮 5-O-葡萄糖苷; 5-Hydroxy-7,8,2',5'-tetramethoxyflavone 5-O-glucoside CFN97595 942626-75-7 C25H28O12 = 520.49 5mg QQ客服:3257982914
    木犀草苷; 木犀草素-7-O-葡萄糖苷; Luteolin-7-O-glucoside CFN98565 5373-11-5 C21H20O11 = 448.38 20mg QQ客服:1413575084
    木犀草素-7-O-葡萄糖醛酸苷; Luteolin-7-O-glucuronide CFN98512 29741-10-4 C21H18O12 = 462.36 20mg QQ客服:1148253675





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