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  • 木犀草素 5-葡萄糖苷

    Luteollin 5-glucoside

    木犀草素 5-葡萄糖苷
    产品编号 CFN98568
    CAS编号 20344-46-1
    分子式 = 分子量 C21H20O11 = 448.38
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Dracocephalum ruyschiana L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    木犀草素 5-葡萄糖苷 CFN98568 20344-46-1 1mg QQ客服:1413575084
    木犀草素 5-葡萄糖苷 CFN98568 20344-46-1 5mg QQ客服:1413575084
    木犀草素 5-葡萄糖苷 CFN98568 20344-46-1 10mg QQ客服:1413575084
    木犀草素 5-葡萄糖苷 CFN98568 20344-46-1 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Michigan State University (USA)
  • Technical University of Denmark (Denmark)
  • Sanford Burnham Medical Research Institute (USA)
  • Utah State University (USA)
  • Universidade Católica Portuguesa (Portugal)
  • Melbourne University (Australia)
  • Kyung Hee University (Korea)
  • Washington State University (USA)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • National Cancer Institute (USA)
  • University of Toronto (Canada)
  • University of South Australia (Australia)
  • University of Brasilia (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biochem Biophys Res Commun.2017, 494(3-4):587-593
  • Molecules.2020, 25(21):5087.
  • Molecules.2019, 24(11):E2102
  • Molecules.2022, 27(2):451.
  • ScientificWorldJournal.2022, 2022:4806889.
  • Chinese Pharmacological Bulletin2019, 35(8):1120-1125
  • J Breast Cancer.2015, 18(2):112-118
  • Nutrients.2019, 12(1)
  • Front Pharmacol.2021, 12:690113.
  • Legume Science2021, 3(4): e101.
  • J Hematol Oncol.2018, 11(1):112
  • J Ethnopharmacol.2017, 198:87-90
  • Evid Based Complement Alternat Med.2016, 2016:1230294
  • Int. Conference on Med. Sci. and Bio.2017, 17973
  • J Mass Spectrom.2022, 57(2):e4810.
  • Food Funct.2020, 11(2):1322-1333.
  • Molecules.2019, 24(7):E1290
  • Pharmaceutics.2021, 13(11):1839.
  • Int J Mol Sci.2022, 23(5):2796.
  • Nutrients.2021, 13(8):2901.
  • Arch Toxicol.2017, 91(10):3225-3245
  • J Chromatogr A.2017, 1518:46-58
  • Nat Prod Sci.2016, 22(2)
  • ...
  • 生物活性
    Description: Luteolin 5-O-β-glucopyranoside has antioxidant activity, it can inhibit lipid peroxidation, and has DPPH radical-scavenging activity.
    In vitro:
    Appl Environ Microbiol. 2003 Oct;69(10):5849-54.
    Anaerobic degradation of flavonoids by Clostridium orbiscindens.[Pubmed: 14532034]

    METHODS AND RESULTS:
    An anaerobic, quercetin-degrading bacterium was isolated from human feces and identified as Clostridium orbiscindens by comparative 16S rRNA gene sequence analysis. The organism was tested for its ability to transform several flavonoids. The isolated C. orbiscindens strain converted quercetin and taxifolin to 3,4-dihydroxyphenylacetic acid; luteolin and eriodictyol to 3-(3,4-dihydroxyphenyl)propionic acid; and apigenin, naringenin, and phloretin to 3-(4-hydroxyphenyl)propionic acid, respectively. Genistein and daidzein were not utilized.
    CONCLUSIONS:
    The glycosidic bonds of luteolin-3-glucoside, Luteollin 5-glucoside, naringenin-7-neohesperidoside (naringin), quercetin-3-glucoside, quercetin-3-rutinoside (rutin), and phloretin-2'-glucoside were not cleaved.
    Planta Med., 2011, 13(5):1-12.
    Relationship between chemical structure and antioxidant activity of luteolin and its glycosides isolated from thymus sipyleus subsp. sipyleus var. sipyleus.[Reference: WebLink]
    One triterpenic acid (ursolic acid), one phenolic acid (rosmarinic acid), and four flavonoids (luteolin, luteolin 7-O-(6"-feruloyl)-β-glucopyranoside, luteolin 5-O-β-glucopyranoside(Luteollin 5-glucoside ), and luteolin 7-O-β-glucuronide) were isolated from the aerial parts of Thymus sipyleus subsp. sipyleus var. sipyleus and identified by spectroscopic methods.
    METHODS AND RESULTS:
    In vitro lipid peroxidation inhibition effects of the compounds were determined using TBA test method in a bovine brain liposome system. All compounds inhibited lipid peroxidation in various degrees except for ursolic acid. The order of the lipid peroxidation activities of luteolin, its glycosides and rosmarinic acid were: Luteolin 7-O-β-glucuronide> luteolin 5-O-β-glucopyranoside(Luteollin 5-glucoside )> luteolin 7-O-(6"-feruloyl)- β-glucopyranoside > rosmarinic acid >luteolin. However, the activity order of the compounds was completely different in DPPH radical-scavenging activity. None of the compounds shows Fe 2+ chelating activity. The results were discussed based on their chemical structures and polarities.
    Food Chem Toxicol . 2012 Jun;50(6):2171-9.
    Anti-inflammatory activity of Korean thistle Cirsium maackii and its major flavonoid, luteolin 5-O-glucoside[Pubmed: 22525859]
    Abstract The anti-inflammatory activity of whole Cirsium maackii (family Compositae) plants and of its major flavonoid, luteolin 5-O-glucoside, was evaluated for their ability to inhibit lipopolysaccharide (LPS)-induced nitric oxide (NO) production, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) protein expression, and tert-butylhydroperoxide (t-BHP)-induced reactive oxygen species (ROS) generation in RAW 264.7 murine macrophage cells. The methanolic extract of C. maackii showed strong anti-inflammatory activity, and was thus fractionated with several solvents. The ethyl acetate-soluble fraction, exhibiting the highest anti-inflammatory activity potential, was further to yield a major flavonoid, luteolin 5-O-glucoside. We found that luteolin 5-O-glucoside, at a non-toxic concentration, inhibited LPS-induced NO production and t-BHP-induced ROS generation in a dose-dependent manner in RAW 264.7 cells. It also suppressed the expression of iNOS and COX-2 in LPS-stimulated macrophages. Furthermore, the efficacies of the methanolic extract of C. maackii in inhibiting both NO and ROS were attributed to its flavonoid content by HPLC analysis. These results indicated that C. maackii whole plants and its flavonoids inhibit the expression of iNOS and COX-2 in through the inhibition of ROS generation, and therefore can be considered as a useful therapeutic and preventive approach for the treatment of various inflammatory and oxidative stress-related diseases. Copyright © 2012 Elsevier Ltd. All rights reserved.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2303 mL 11.1513 mL 22.3025 mL 44.605 mL 55.7563 mL
    5 mM 0.4461 mL 2.2303 mL 4.4605 mL 8.921 mL 11.1513 mL
    10 mM 0.223 mL 1.1151 mL 2.2303 mL 4.4605 mL 5.5756 mL
    50 mM 0.0446 mL 0.223 mL 0.4461 mL 0.8921 mL 1.1151 mL
    100 mM 0.0223 mL 0.1115 mL 0.223 mL 0.4461 mL 0.5576 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    木樨草素 7,3'-二-O-葡糖醛酸苷; Luteolin 7,3'-di-O-glucuronide CFN98573 53965-08-5 C27H26O18 = 638.48 5mg QQ客服:1148253675
    6-羟基木犀草苷; 6-Hydroxyluteolin 7-glucoside CFN91094 54300-65-1 C21H20O12 = 464.38 10mg QQ客服:3257982914
    假荆芥属苷; Nepetin-7-glucoside CFN90438 569-90-4 C22H22O12 = 478.40 20mg QQ客服:2932563308
    万寿菊苷; Patulitrin CFN95153 19833-25-1 C22H22O13 = 494.4 5mg QQ客服:2159513211
    柯伊利素-7-O-葡萄糖苷; Chrysoeriol-7-O-glucoside CFN93021 19993-32-9 C22H22O11 = 462.4 5mg QQ客服:215959384
    香叶木素7-O-beta-D-葡萄糖苷; Diosmetin-7-O-beta-D-glucopyranoside CFN98502 20126-59-4 C22H22O11 = 462.41 20mg QQ客服:2932563308
    地奥司明; Diosmin CFN98145 520-27-4 C28H32O15 = 608.54 20mg QQ客服:2159513211
    新地奥司明; Neodiosmin CFN93075 38665-01-9 C28H32O15 = 608.54 20mg QQ客服:2932563308
    Lethedoside A; Lethedoside A CFN98100 221289-20-9 C24H26O11 = 490.5 5mg QQ客服:3257982914
    Lethedioside A; Lethedioside A CFN98201 221289-31-2 C29H34O15 = 622.6 5mg QQ客服:3257982914

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