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  • 橙皮素7-O-葡萄糖苷

    Hesperetin 7-O-glucoside

    产品编号 CFN98405
    CAS编号 31712-49-9
    分子式 = 分子量 C22H24O11 = 464.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The herbs of Mentha aquatica
    产品名称 产品编号 CAS编号 包装 QQ客服
    橙皮素7-O-葡萄糖苷 CFN98405 31712-49-9 1mg QQ客服:1413575084
    橙皮素7-O-葡萄糖苷 CFN98405 31712-49-9 5mg QQ客服:1413575084
    橙皮素7-O-葡萄糖苷 CFN98405 31712-49-9 10mg QQ客服:1413575084
    橙皮素7-O-葡萄糖苷 CFN98405 31712-49-9 20mg QQ客服:1413575084
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    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
  • Universite de Lille1 (France)
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  • ...
  • 生物活性
    Description: Hesperetin 7-O-glucoside and prunin are direct precursors of naringin and neohesperidin, respectively, in C. aurantium. Hesperetin 7-O-glucoside shows inhibition of human HMG-CoA reductase, it also exhibits effective inhibition of the growth of Helicobacter pylori. Hesperetin 7-O-glucoside can reduce blood pressure in healthy volunteers.
    Targets: HMG-CoA Reductase | Antifection
    In vitro:
    Food Chem. 2012 Dec 15;135(4):2253-9.
    Enzymatic bioconversion of citrus hesperidin by Aspergillus sojae naringinase: enhanced solubility of hesperetin-7-O-glucoside with in vitro inhibition of human intestinal maltase, HMG-CoA reductase, and growth of Helicobacter pylori.[Pubmed: 22980799]

    Hesperetin 7-O-glucoside (Hes-7-G) was produced by the enzymatic conversion of hesperidin by Aspergillus sojae naringinase due to the removal of the terminal rhamnose.Extracts from orange juice and peel containing the hesperidin were so treated by this enzyme that the hesperidin could also be converted to Hesperetin 7-O-glucoside . The solubility of Hesperetin 7-O-glucoside in 10% ethanol was enhanced 55- and 88-fold over those of hesperidin and hesperetin, respectively, which may make Hesperetin 7-O-glucoside more bioavailable. Hesperetin 7-O-glucoside was 1.7- and 2.4-fold better than hesperidin and hesperetin, respectively, in the inhibition of human intestinal maltase. Hesperetin 7-O-glucoside was more potent by 2- and 4-fold than hesperidin in the inhibition of human HMG-CoA reductase. Additionally, Hesperetin 7-O-glucoside exhibited more effective inhibition of the growth of Helicobacter pylori than hesperetin, while its effectiveness was similar to that of hesperidin.
    Therefore, the results suggest that bioconverted Hesperetin 7-O-glucoside is more effective and bioavailable than hesperidin, as it has enhanced inhibitory and solubility properties.
    In vivo:
    Mol Nutr Food Res. 2015 May 27.
    Gastrointestinal absorption and metabolism of hesperetin-7-O-rutinoside and hesperetin-7-O-glucoside in healthy humans.[Pubmed: 26018925]
    Hesperetin 7-O-glucoside (hesperidin) reduces blood pressure in healthy volunteers but its intestinal absorption and metabolism are not fully understood. Therefore, we aimed to determine sites of absorption and metabolism of dietary flavanone glycosides in humans.
    Using a single blind, randomized crossover design, we perfused equimolar amounts of Hesperetin 7-O-glucoside and Hesperetin 7-O-glucoside directly into the proximal jejunum of healthy volunteers. We assessed the appearance of metabolites in the perfusate, blood and urine, to determine the sites of metabolism and excretion, and compared this to oral administration. Theglucoside was rapidly hydrolysed by brush border enzymes without any contribution from pancreatic, stomach or other secreted enzymes, or from bacterial enzymes. Only ∼3% of the dose was recovered intact in the perfusate, indicating high absorption. A proportion was effluxed directly back into the perfused segment mainly in the form of hesperetin-3'-O-sulfate. In contrast, very little hydrolysis or absorption of Hesperetin 7-O-glucoside was observed with ∼80% recovered in the perfusate, no hesperetin metabolites were detected in blood and only traces were excreted in urine.
    The data elucidate the pathways of metabolism of dietary hesperidin in vivo and will facilitate better design of mechanistic studies both in vivo and in vitro. The trial was registered at Medical Faculty of the University of Tübingen.
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1533 mL 10.7666 mL 21.5332 mL 43.0663 mL 53.8329 mL
    5 mM 0.4307 mL 2.1533 mL 4.3066 mL 8.6133 mL 10.7666 mL
    10 mM 0.2153 mL 1.0767 mL 2.1533 mL 4.3066 mL 5.3833 mL
    50 mM 0.0431 mL 0.2153 mL 0.4307 mL 0.8613 mL 1.0767 mL
    100 mM 0.0215 mL 0.1077 mL 0.2153 mL 0.4307 mL 0.5383 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    桃苷; Persicoside CFN97908 28978-03-2 C23H26O11 = 478.5 5mg QQ客服:2159513211
    甲基橙皮甙; 甲基橙皮苷; Methyl hesperidin CFN99584 11013-97-1 C29H36O15 = 624.59 20mg QQ客服:2056216494
    地奥司明杂质8; Diosmin Impurity 8 CFN95309 28719-21-3 C30H38O15 = 638.6 10mg QQ客服:2159513211
    (R)-5,3'-二甲基橙皮苷; (R)-5,3'-Dimethyl hesperidin CFN95310 N/A C30H38O15 = 638.6 5mg QQ客服:2159513211
    新橙皮苷; Neohesperidin CFN99125 13241-33-3 C28H34O15 = 610.56 20mg QQ客服:3257982914
    圣草酚-8-葡萄糖苷; Eriodictyol-8-glucoside CFN91942 153733-96-1 C21H22O11 = 450.39 5mg QQ客服:2056216494
    (R)-圣草酚-8-C-beta-D-葡萄糖苷; (R)-Eriodictyol-8-C-beta-D-glucopyranoside CFN91943 1023271-51-3 C21H22O11 = 450.39 5mg QQ客服:1457312923
    Beta-D-glucopyranosiduronic acid; Beta-D-glucopyranosiduronic acid CFN92281 60092-34-4 C21H20O11 = 448.4 5mg QQ客服:2159513211
    圣草酚-7-O-葡萄糖苷; Eriodictyol-7-O-glucoside CFN97865 38965-51-4 C21H22O11 = 450.39 10mg QQ客服:1413575084
    圣草酚-7-O-葡萄糖醛酸苷; Eriodictyol 7-O-glucuronide CFN95290 125535-06-0 C21H20O12 = 464.4 10mg QQ客服:2159513211





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