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  • Desoxo-narchinol A

    Desoxo-narchinol A

    Desoxo-narchinol A
    产品编号 CFN89358
    CAS编号 53859-06-6
    分子式 = 分子量 C12H16O2 = 192.25
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The rhizomes and roots of Nardostachys chinensis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Desoxo-narchinol A CFN89358 53859-06-6 1mg QQ客服:3257982914
    Desoxo-narchinol A CFN89358 53859-06-6 5mg QQ客服:3257982914
    Desoxo-narchinol A CFN89358 53859-06-6 10mg QQ客服:3257982914
    Desoxo-narchinol A CFN89358 53859-06-6 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Indian Institute of Science (India)
  • University of Toronto (Canada)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Texas A&M University (USA)
  • Aveiro University (Portugal)
  • Shanghai University of TCM (China)
  • Kyushu University (Japan)
  • Medizinische Universit?t Wien (Austria)
  • Universidade do Porto (Portugal)
  • Gyeongsang National University (Korea)
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  • Stanford University (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Funct.2022, 13(23):12105-12120.
  • Microchemical Journal2024: 196:109676.
  • Molecules.2022, 27(13):4227.
  • PLoS One.2017, 12(8):e0181191
  • Sci Rep. 2017, 8207(7)
  • Applied Biological Chemistry2022, 65(85).
  • Drug Dev Res.2020, doi: 10.1002
  • Molecules.2018, 23(2)
  • Evid-Based Compl Alt2020, 7202519:13
  • Phytomedicine.2018, 38:12-23
  • Cell Mol Biol(Noisy-le-grand)2019, 65(7):77-83
  • BMC Complement Altern Med.2016, 16:213
  • Nutrients.2021, 13(8):2901.
  • Korean J Dent Mater2020, 47(2):63-70.
  • Curr Issues Mol Biol.2022, 44(10):5106-5116.
  • Food Chem.2017, 221:1135-1144
  • Molecules2022, 27(12):3824.
  • Appl. Sci.2021, 11(24),12080
  • Redox Biology2024, 103197.
  • Molecules. 2013, 18(11):14105-21
  • Molecules.2016, 21(10)
  • VNU Journal of Science: Med.& Pharm. Sci.2022, 38(2):2588-1132.
  • Appl. Sci.2020, 10(16),5482.
  • ...
  • 生物活性
    Description: Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity against LPS-induced NO production. Desoxo-narchinol A shows cytotoxic activity against P-388 cells.
    Targets: IL Receptor | TNF-α | NF-kB | p38MAPK | NOS | COX | NO | JNK | ERK | PGE
    In vitro:
    Bioorg Med Chem Lett. 2012 Jan 1;22(1):706-8.
    Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages.[Pubmed: 22079762 ]

    METHODS AND RESULTS:
    The activity-guided fractionation of the MeOH extract of the rhizomes and roots of Nardostachys chinensis led to the isolation of two new sesquiterpenoids, narchinol B (8) and narchinol C (9), along with 10 known compounds, ursolic acid (1), nardosinone (2), pinoresinol (3), Desoxo-narchinol A (4), kanshone B (5), epoxyconiferyl alcohol (6), debilon (7), 4α,5-dimethyl-1,3-dioxo-1,2,3,4,4α,5,6,7-octahydronaphthalene (10), p-coumaric acid (11), and isoferulic acid (12). Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR.
    CONCLUSIONS:
    Among the isolates, compounds 2, 4, 5, 8 and 9 showed inhibitory activity against LPS-induced NO production with IC(50) values of 4.6-21.6 μM.
    In vivo:
    Int Immunopharmacol. 2015 Dec;29(2):730-738.
    Anti-inflammatory effect of desoxo-narchinol-A isolated from Nardostachys jatamansi against lipopolysaccharide.[Pubmed: 26371857]
    We previously reported that Nardostachys jatamansi (NJ) exhibits anti-inflammatory activity against lipopolysaccharide (LPS). However, the active compound in NJ is unknown.
    METHODS AND RESULTS:
    Therefore, here, we examined the effects of Desoxo-narchinol A (DN) isolated from NJ against LPS-induced inflammation. To demonstrate the anti-inflammatory effect of DN against LPS, we used two models; murine endotoxin shock model for in vivo model, and peritoneal macrophage responses for in vitro. In endotoxin shock model, DN was administrated intraperitoneally 1h before LPS challenge, then we evaluated mice survival rates and organ damages. Pretreatment with DN (0.05mg/kg, 0.1mg/kg, or 0.5mg/kg) dramatically reduced mortality in a murine LPS-induced endotoxin shock model. Furthermore, DN inhibited tissue injury and production of pro-inflammatory cytokines, such as interleukin (IL)-1β, IL-6, and tumor necrosis factor alpha (TNF-α), in the liver and lung. In in vitro macrophage model, we examined the inflammatory mediators and regulatory mechanisms such as mitogen-activated protein kinases (MAPKs) and nuclear factor kappa B (NF-κB). DN inhibited the production of inflammatory mediators, such as inducible nitric oxide synthase (iNOS) and its derivative nitric oxide (NO), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), IL-1β, IL-6 and TNF-α and H3 protein acetylation in murine peritoneal macrophages. DN also inhibited p38 activation, but not extracellular signal-regulated kinase (ERK), c-jun NH2-terminal kinase (JNK), and NF-κB.
    CONCLUSIONS:
    These results suggest that DN from NJ exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.2016 mL 26.0078 mL 52.0156 mL 104.0312 mL 130.039 mL
    5 mM 1.0403 mL 5.2016 mL 10.4031 mL 20.8062 mL 26.0078 mL
    10 mM 0.5202 mL 2.6008 mL 5.2016 mL 10.4031 mL 13.0039 mL
    50 mM 0.104 mL 0.5202 mL 1.0403 mL 2.0806 mL 2.6008 mL
    100 mM 0.052 mL 0.2601 mL 0.5202 mL 1.0403 mL 1.3004 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Nardoaristolone B; Nardoaristolone B CFN95203 1422517-82-5 C14H18O2 = 218.3 5mg QQ客服:3257982914
    甘松香酮 A; Kanshone A CFN96977 115356-18-8 C15H22O2 = 234.33 5mg QQ客服:1457312923
    甘松新酮二醇; Nardosinonediol CFN89546 20489-11-6 C15H24O3 = 252.34 5mg QQ客服:2159513211
    异甘松新酮; Isonardosinone CFN95180 27062-01-7 C15H20O4 = 264.3 10mg QQ客服:215959384
    Narchinol B; Narchinol B CFN89522 1356822-09-7 C12H16O3 = 208.25 5mg QQ客服:2056216494
    Desoxo-narchinol A; Desoxo-narchinol A CFN89358 53859-06-6 C12H16O2 = 192.25 5mg QQ客服:2056216494
    努特卡酮, 诺卡酮; Nootkatone CFN98699 4674-50-4 C15H22O = 218.3 20mg QQ客服:3257982914
    Oxyphyllol B; Oxyphyllol B CFN95575 226546-99-2 C15H22O2 = 234.3 5mg QQ客服:215959384
    Tessaric acid; Tessaric acid CFN95182 58142-10-2 C15H20O3 = 248.3 5mg QQ客服:1457312923
    苷松新酮; Nardosinone CFN90178 23720-80-1 C15H22O3 = 250.33 20mg QQ客服:215959384

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