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  • Nardoaristolone B

    Nardoaristolone B

    Nardoaristolone B
    产品编号 CFN95203
    CAS编号 1422517-82-5
    分子式 = 分子量 C14H18O2 = 218.3
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 The roots of Nardostachys chinensis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Nardoaristolone B CFN95203 1422517-82-5 1mg QQ客服:2159513211
    Nardoaristolone B CFN95203 1422517-82-5 5mg QQ客服:2159513211
    Nardoaristolone B CFN95203 1422517-82-5 10mg QQ客服:2159513211
    Nardoaristolone B CFN95203 1422517-82-5 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Medizinische Universit?t Wien (Austria)
  • Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)
  • Anna University (India)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Yale University (USA)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • University of Minnesota (USA)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Max-Planck-Insitut (Germany)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Sanford Burnham Medical Research Institute (USA)
  • Universidad Industrial de Santander (Colombia)
  • Sant Gadge Baba Amravati University (India)
  • Northeast Normal University Changchun (China)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Nat Prod.2022, 85(5):1351-1362.
  • Pharmaceuticals (Basel).2022, 15(8):982.
  • Int J Mol Sci.2020, 21(24):9369.
  • Integr Med Res.2017, 6(4):395-403
  • Preprints2022, 202211.0388.v1.
  • Food and Bioprocess Technology2017, 10(6):1074-1092
  • Pharmaceuticals (Basel).2022, 15(5):591.
  • LWT2021, 138:110397.
  • Front Aging Neurosci.2018, 10:269
  • Anticancer Res.2021, 41(3):1357-1364.
  • Asian J Beauty Cosmetol2021, 19(1): 57-64.
  • Front Plant Sci.2018, 9:1424
  • Pharm Biol.2017, 55(1):360-366
  • J Food Sci Technol.2019, 56(5):2712-2720
  • Applied Biological Chemistry2023, 66(58):112.
  • Int J Mol Sci.2023, 24(22):16465.
  • Int J Mol Sci.2023, 24(3):2102.
  • Int J Cosmet Sci.2023, 45(2):155-165.
  • Processes2021, 9(1), 153;
  • Life (Basel).2022, 12(10):1630.
  • Environ Toxicol.2024, 39(4):2417-2428.
  • Oxid Med Cell Longev2020, 12
  • Nutrients.2018, 10(10)
  • ...
  • 生物活性
    Description: Nardoaristolone B, a nor-sesquiterpenoid with an unusual fused ring system and having protective effects on the injury of neonatal rat cardiomyocytes. The novel mosquito-repellentsynthetic hydrindanesbased on noreremophilanes and nardoaristolone B which show increasedactivity against adult females of Aedes aegypti.
    In vitro:
    Molecules. 2018 Sep 17;23(9). pii: E2367.
    Isolation of Novel Sesquiterpeniods and Anti-neuroinflammatory Metabolites from Nardostachys jatamansi.[Pubmed: 30227591]
    Nardostachys jatamansi contains various types of sesquiterpenoids that may play an important role in the potency of plant's anti-inflammatory effects, depending on their structure.
    METHODS AND RESULTS:
    In this study, five new sesquiterpenoids, namely kanshone L (1), kanshone M (2), 7-methoxydesoxo-narchinol (3), kanshone N (4), and nardosdaucanol (5), were isolated along with four known terpenoids (kanshone D (6), nardosinanone G (7), narchinol A (8), and nardoaristolone B (9)) from the rhizomes and roots of Nardostachys jatamansi. Their structures were determined by analyzing 1D and 2D NMR and MS data. Among the nine sesquiterpenoids, compounds 3, 4, and 8 were shown to possess dose-dependent inhibitory effects against lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production in BV2 microglial cells. Furthermore, compounds 3, 4, and 8 exhibited anti-neuroinflammatory effects by inhibiting the production of pro-inflammatory mediators, including prostaglandin E₂ (PGE₂), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) proteins, as well as pro-inflammatory cytokines, such as interleukin (IL)-1β, IL-12 and tumor necrosis factor-α (TNF-α), in LPS-stimulated BV2 microglial cells. Moreover, these compounds were shown to inhibit the activation of the NF-κB signaling pathway in LPS-stimulated BV2 microglial cells by suppressing the phosphorylation of IκB-α and blocking NF-κB translocation.
    CONCLUSIONS:
    In conclusion, five new and four known sesquiterpenoids were isolated from Nardostachys jatamansi, and compounds 3, 4, and 8 exhibited anti-neuroinflammatory effects in LPS-stimulated BV2 microglial cells through inhibiting of NF-κB signaling pathway.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.5809 mL 22.9043 mL 45.8085 mL 91.617 mL 114.5213 mL
    5 mM 0.9162 mL 4.5809 mL 9.1617 mL 18.3234 mL 22.9043 mL
    10 mM 0.4581 mL 2.2904 mL 4.5809 mL 9.1617 mL 11.4521 mL
    50 mM 0.0916 mL 0.4581 mL 0.9162 mL 1.8323 mL 2.2904 mL
    100 mM 0.0458 mL 0.229 mL 0.4581 mL 0.9162 mL 1.1452 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    马兜铃酮; Aristolone CFN96139 6831-17-0 C15H22O = 218.3 20mg QQ客服:1413575084
    Axinysone B ; Axinysone B CFN89436 1114491-60-9 C15H22O2 = 234.33 5mg QQ客服:1413575084
    甘松香酮H; Kanshone H CFN89349 1445952-33-9 C15H20O = 216.31 5mg QQ客服:2056216494
    1(10)-Aristolen-2-one; 1(10)-Aristolen-2-one CFN89356 28398-06-3 C15H22O = 218.33 5 mg QQ客服:215959384
    Aristola-1(10),8-dien-2-one; Aristola-1(10),8-dien-2-one CFN89328 22391-34-0 C15H20O = 216.32 5mg QQ客服:1457312923
    Debilon; Debilon CFN89419 26808-51-5 C15H22O2 = 234.33 5 mg QQ客服:3257982914
    Nardoaristolone B; Nardoaristolone B CFN95203 1422517-82-5 C14H18O2 = 218.3 5mg QQ客服:2056216494
    甘松香酮 A; Kanshone A CFN96977 115356-18-8 C15H22O2 = 234.33 5mg QQ客服:2159513211
    甘松新酮二醇; Nardosinonediol CFN89546 20489-11-6 C15H24O3 = 252.34 5mg QQ客服:1457312923
    异甘松新酮; Isonardosinone CFN95180 27062-01-7 C15H20O4 = 264.3 10mg QQ客服:2056216494

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