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  • 异甘松新酮

    Isonardosinone

    异甘松新酮
    产品编号 CFN95180
    CAS编号 27062-01-7
    分子式 = 分子量 C15H20O4 = 264.3
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Sesquiterpenoids
    植物来源 The rhizomes and roots of Nardostachys chinensis.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异甘松新酮 CFN95180 27062-01-7 1mg QQ客服:1457312923
    异甘松新酮 CFN95180 27062-01-7 5mg QQ客服:1457312923
    异甘松新酮 CFN95180 27062-01-7 10mg QQ客服:1457312923
    异甘松新酮 CFN95180 27062-01-7 20mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Pennsylvania State University (USA)
  • Stanford University (USA)
  • Harvard University (USA)
  • Center for protein Engineering (CIP) (Belgium)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Subang Jaya Medical Centre (Malaysia)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • University of Dicle (Turkey)
  • University of the Basque Country (Spain)
  • Kitasato University (Japan)
  • Leibniz Institute of Plant Biochemistry (Germany)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Universidad de La Salle (Mexico)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Funct.2022, 13(23):12105-12120.
  • Metabolites.2020, 10(12):497.
  • Industrial Food Engineering2015, 19(4):408-413
  • Int J Pharmacol2020, 16:1-9
  • Journal of Apicultural Research2021, 60(1).
  • Phytother Res.2018, 32(5):923-932
  • Acta Biochim Pol.2015, 62(2):253-8
  • Mol Pharm.2017, 14(9):3164-3177
  • BMC Plant Biol.2020, 20(1):214.
  • Plant Cell, Tissue and Organ Culture (PCTOC)2020, 143, 45-60(2020)
  • Internoational J of Toxicology2020, 10.1177.
  • Cancer Sci.2022, 113(4):1406-1416.
  • Food Res Int.2018, 106:909-919
  • Separations2021, 8(1), 1.
  • Phys Chem Chem Phys.2018, 20(23):15986-15994
  • Metabolites2022, 12(6),507.
  • Int J Mol Sci.2022, 23(23):14826.
  • J Nat Prod.2022, 85(5):1351-1362.
  • Molecules.2023, 28(9):3685.
  • Sci Rep.2021, 11(1):10931.
  • Neurotoxicology.2022, 91:218-227.
  • J Sep Sci.2020, 43(22):4148-4161.
  • AMB Express2020. 10(1):126.
  • ...
  • 生物活性
    Description: Isonardosinone shows potential role in the treatment of neuroinflammation conditions, it inhibits NF-κB- and MAPK-mediated inflammatory pathways.
    Targets: NF-κB | MAPK
    In vitro:
    Inflammation. 2018 Aug;41(4):1215-1228.
    Nardosinone-Type Sesquiterpenes from the Hexane Fraction of Nardostachys jatamansi Attenuate NF-κB and MAPK Signaling Pathways in Lipopolysaccharide-Stimulated BV2 Microglial Cells.[Pubmed: 29616391 ]

    METHODS AND RESULTS:
    Four nardosinone-type sesquiterpenes, nardosinone, isonardosinone, kanshone E, and kanshone B, were isolated from the hexane fraction of Nardostachys jatamansi (Valerianaceae) methanol extract. The structures of these compounds were mainly established by analyzing the data obtained from nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS). In this study, we investigated their anti-neuroinflammatory effects in lipopolysaccharide (LPS)-induced BV2 microglial cells. The results showed that nardosinone-type sesquiterpenes inhibited the production of pro-inflammatory mediators, such as nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-induced BV2 microglial cells. These inhibitory effects were correlated with the downregulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Moreover, these sesquiterpenes also attenuated the mRNA expression of pro-inflammatory cytokines including interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) in LPS-induced BV2 microglial cells. During the evaluation of the signaling pathways involved in these anti-neuroinflammatory effects, western blot analysis and DNA-binding activity assay revealed that the suppression of inflammatory reaction by these sesquiterpenes was mediated by the inactivation of nuclear factor-kappa B (NF-κB) pathway. These sesquiterpenes also suppressed the phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) signaling pathways in LPS-stimulated BV2 microglial cells.
    CONCLUSIONS:
    Taken together, these four nardosinone-type sesquiterpenes inhibited NF-κB- and MAPK-mediated inflammatory pathways, demonstrating their potential role in the treatment of neuroinflammation conditions.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.7836 mL 18.9179 mL 37.8358 mL 75.6716 mL 94.5895 mL
    5 mM 0.7567 mL 3.7836 mL 7.5672 mL 15.1343 mL 18.9179 mL
    10 mM 0.3784 mL 1.8918 mL 3.7836 mL 7.5672 mL 9.4589 mL
    50 mM 0.0757 mL 0.3784 mL 0.7567 mL 1.5134 mL 1.8918 mL
    100 mM 0.0378 mL 0.1892 mL 0.3784 mL 0.7567 mL 0.9459 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    1(10)-Aristolen-2-one; 1(10)-Aristolen-2-one CFN89356 28398-06-3 C15H22O = 218.33 5 mg QQ客服:2056216494
    Aristola-1(10),8-dien-2-one; Aristola-1(10),8-dien-2-one CFN89328 22391-34-0 C15H20O = 216.32 5mg QQ客服:2056216494
    Debilon; Debilon CFN89419 26808-51-5 C15H22O2 = 234.33 5 mg QQ客服:215959384
    Nardoaristolone B; Nardoaristolone B CFN95203 1422517-82-5 C14H18O2 = 218.3 5mg QQ客服:2056216494
    甘松香酮 A; Kanshone A CFN96977 115356-18-8 C15H22O2 = 234.33 5mg QQ客服:2056216494
    甘松新酮二醇; Nardosinonediol CFN89546 20489-11-6 C15H24O3 = 252.34 5mg QQ客服:1457312923
    异甘松新酮; Isonardosinone CFN95180 27062-01-7 C15H20O4 = 264.3 10mg QQ客服:2159513211
    Narchinol B; Narchinol B CFN89522 1356822-09-7 C12H16O3 = 208.25 5mg QQ客服:1413575084
    Desoxo-narchinol A; Desoxo-narchinol A CFN89358 53859-06-6 C12H16O2 = 192.25 5mg QQ客服:2056216494
    努特卡酮, 诺卡酮; Nootkatone CFN98699 4674-50-4 C15H22O = 218.3 20mg QQ客服:215959384

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