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  • 葫芦素A

    Cucurbitacin A

    葫芦素A
    产品编号 CFN90324
    CAS编号 6040-19-3
    分子式 = 分子量 C32H46O9 = 574.71
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The rhizomes of Hemsleya amabilis Diels.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    葫芦素A CFN90324 6040-19-3 1mg QQ客服:1148253675
    葫芦素A CFN90324 6040-19-3 5mg QQ客服:1148253675
    葫芦素A CFN90324 6040-19-3 10mg QQ客服:1148253675
    葫芦素A CFN90324 6040-19-3 20mg QQ客服:1148253675
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Tokyo Woman's Christian University (Japan)
  • University of Wollongong (Australia)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • Universiti Kebangsaan Malaysia (Malaysia)
  • The Institute of Cancer Research (United Kingdom)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Istanbul University (Turkey)
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  • Universidade de Franca (Brazil)
  • University of Oslo (Norway)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Appl. Sci.2022, 12(4), 2032.
  • Nat Commun.2021, 12(1):681.
  • Korean J Acupunct2020, 37:104-121
  • Molecules.2021, 26(9):2765.
  • Food Chem.2019, 276:768-775
  • Int J Anal Chem.2017, 2017:1254721
  • Molecules.2021, 26(13):4081.
  • PLoS One.2017, 12(8):e0181191
  • J of l. Chroma.&Related Tech2020, 43(11-12):414-423.
  • J Nat Prod.2015, 78(6):1339-4
  • Molecules.2019, 24(6):E1155
  • Pharmacogn Mag.2015, 11(43):562-6
  • Pak J Pharm Sci.2019, 32(6):2879-2885
  • Saudi Pharm J2020, 10.1016
  • Crystals2020, 10(3), 206.
  • Fitoterapia.2015, 100:179-86
  • Oncol Rep.2016, 35(3):1356-64
  • Journal of Apicultural Research2021, 60(1).
  • Universidade Estadual Paulista2017, 42785
  • Chemistry of Natural Compounds2018, 54(3):572-576
  • Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247
  • Neurotox Res.2020, 38(1):163-174.
  • Toxins (Basel).2021, 13(9):593.
  • ...
  • 生物活性
    Description: Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase.
    Targets: ROCK
    In vitro:
    Biochem. Pharmacol., 2015, 102:45-63.
    Cucurbitacin I elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-kinase.[Pubmed: 26707799 ]
    Cucurbitacins are cytotoxic triterpenoid sterols isolated from plants. One of their earliest cellular effect is the aggregation of actin associated with blockage of cell migration and division that eventually lead to apoptosis.
    METHODS AND RESULTS:
    We unravel here that cucurbitacin I actually induces the co-aggregation of actin with phospho-myosin II. This co-aggregation most probably results from the stimulation of the Rho/ROCK pathway and the direct inhibition of the LIMKinase. We further provide data that suggest that the formation of these co-aggregates is independent of a putative pro-oxidant status of cucurbitacin I.
    CONCLUSIONS:
    The results help to understand the impact of cucurbitacins on signal transduction and actin dynamics and open novel perspectives to use it as drug candidates for cancer research.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.74 mL 8.7 mL 17.4001 mL 34.8002 mL 43.5002 mL
    5 mM 0.348 mL 1.74 mL 3.48 mL 6.96 mL 8.7 mL
    10 mM 0.174 mL 0.87 mL 1.74 mL 3.48 mL 4.35 mL
    50 mM 0.0348 mL 0.174 mL 0.348 mL 0.696 mL 0.87 mL
    100 mM 0.0174 mL 0.087 mL 0.174 mL 0.348 mL 0.435 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异葫芦素 D; Isocucurbitacin D CFN95326 68422-20-8 C30H44O7 = 516.7 5mg QQ客服:1413575084
    23,24-二氢异葫芦素 B; 23,24-dihydroisocucurbitacin B CFN92894 68354-21-2 C32H48O8 = 560.72 5mg QQ客服:2932563308
    异葫芦素 B; Isocucurbitacin B CFN91003 17278-28-3 C32H46O8 = 558.7 10mg QQ客服:2932563308
    葫芦素B; Cucurbitacin B CFN99129 6199-67-3 C32H46O8 = 558.70 20mg QQ客服:1413575084
    葫芦素B 2-O-Beta-D-葡萄糖苷; Cucurbitacin B 2-O-beta-D-glucoside CFN92141 65247-27-0 C38H56O13 = 720.9 5mg QQ客服:2932563308
    葫芦素A; Cucurbitacin A CFN90324 6040-19-3 C32H46O9 = 574.71 5mg QQ客服:1148253675
    葫芦素I ; Cucurbitacin I CFN70316 2222-07-3 C30H42O7 = 514.7 5mg QQ客服:1413575084
    葫芦素E; Cucurbitacin E CFN90154 18444-66-1 C32H44O8 = 556.67 10mg QQ客服:2932563308
    葫芦素S; 雪胆素甲; Cucurbitacin S CFN90535 60137-06-6 C30H42O6 = 498.65 5mg QQ客服:2159513211
    四氢异葫芦素I; Tetrahydroisocucurbitacin I CFN92892 3877-89-2 C30H46O7 = 518.68 5mg QQ客服:2159513211

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