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  • 葫芦素I

    Cucurbitacin I

    葫芦素I
    产品编号 CFN70316
    CAS编号 2222-07-3
    分子式 = 分子量 C30H42O7 = 514.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The rhizomes of Hemsleya amabilis Diels.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    葫芦素I CFN70316 2222-07-3 1mg QQ客服:1413575084
    葫芦素I CFN70316 2222-07-3 5mg QQ客服:1413575084
    葫芦素I CFN70316 2222-07-3 10mg QQ客服:1413575084
    葫芦素I CFN70316 2222-07-3 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Max Rubner-Institut (MRI) (Germany)
  • Chulalongkorn University (Thailand)
  • Centralised Purchases Unit (CPU), B.I.T.S (India)
  • Amity University (India)
  • University of Bordeaux (France)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • Srinakharinwirot University (Thailand)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Washington State University (USA)
  • University of Malaya (Malaysia)
  • Aarhus University (Denmark)
  • University of Canterbury (New Zealand)
  • Universiti Kebangsaan Malaysia (Malaysia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Microbiol Immunol Infect.2021, S1684-1182(21)00142-0.
  • Journal of Food Hygiene and Safety2019, 34(5):413-420
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • J Ethnopharmacol.2020, 260:112988.
  • Food Analytical Methods2020, 1-10
  • Food Res Int.2018, 106:909-919
  • Front Cell Dev Biol.2021, 9:764263.
  • Environ Toxicol.2019, 34(12):1354-1362
  • J Agric Food Chem.2022, 70(51):16176-16187.
  • Environ Toxicol.2022, 37(3):514-526.
  • Int Immunopharmacol.2023, 7:127:111322.
  • J Pharmaceut Biomed2020, 178:112894
  • J Plant Biotechnol.2023, 50:070-075.
  • J Ethnopharmacol.2017, 206:327-336
  • J Chromatogr B Analyt Technol Biomed Life Sci. 2017, 1064:115-123
  • New Zealand J. Forestry Sci.2014, 44:17
  • Nat Prod Sci.2018, 24(3):206
  • 2023, 24(6):5769.Int J Mol Sci.
  • Separation Science Plus2022, sscp.202200048.
  • Plant Cell Tiss Org2020, 1-16
  • Food Sci Nutr.2019, 8(1):246-256
  • Pharmaceutics.2022, 14(12):2765.
  • Neurochem Res.2021, s11064-021-03449-0
  • ...
  • 生物活性
    Description: Cucurbitacin I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells. Cucurbitacin I elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-kinase, it promotes strong CD8(+) T-cell responses and cures highly aggressive lymphoma. Cucurbitacin I may inhibit P-gp-mediated transport and interact with P-gp substrates in the intestinal absorption process.
    Targets: RhoA | ROCK | P-gp | STAT | EGFR | PTEN | p53 | PARP | JAK
    In vitro:
    Food and Chemical Toxicology, 2007, 44(12):2033-2039.
    Inhibition of P-glycoprotein-mediated transport by terpenoids contained in herbal medicines and natural products[Reference: WebLink]
    Terpenoids form a large and structurally diverse family of natural products and are ingredients of various herbal medicines. We have investigated possible interactions between herbal medicines and conventional medicines, and recently reported that monoterpenoids contained in Zanthoxyli Fructus can be potent inhibitors of P-glycoprotein (P-gp).
    METHODS AND RESULTS:
    In the present study, the influence of 70 kinds of terpenoids present in natural products on P-gp-mediated efflux transport was investigated. LLC-GA5-COL150 cells transfected with human MDR1 cDNA encoding P-gp were used to screen the terpenoids. Large increases in the intracellular accumulation of [(3)H]digoxin were observed in the presence of (R)-(+)-citronellal, (S)-(-)-beta-citronellol, alpha-terpinene, terpinolene, (-)-beta-pinene, abietic acid, ophiobolin A, cucurbitacin I, and glycyrrhetic acid. A study of the concentration-dependency revealed that the IC(50) of ophiobolin A, glycyrrhetic acid, (R)-(+)-citronellal, abietic acid, and cucurbitacin I was smaller than that of verapamil. The transcellular transport of [(3)H]digoxin across Caco-2 cell monolayers was then examined in the presence of (R)-(+)-citronellal, abietic acid, and glycyrrhetic acid. Significant increases in the apical-to-basolateral transport and decreases in the basolateral-to-apical transport and efflux ratio were demonstrated.
    CONCLUSIONS:
    These findings suggest that some natural products containing these terpenoids may inhibit P-gp-mediated transport and interact with P-gp substrates in the intestinal absorption process.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9429 mL 9.7144 mL 19.4288 mL 38.8576 mL 48.572 mL
    5 mM 0.3886 mL 1.9429 mL 3.8858 mL 7.7715 mL 9.7144 mL
    10 mM 0.1943 mL 0.9714 mL 1.9429 mL 3.8858 mL 4.8572 mL
    50 mM 0.0389 mL 0.1943 mL 0.3886 mL 0.7772 mL 0.9714 mL
    100 mM 0.0194 mL 0.0971 mL 0.1943 mL 0.3886 mL 0.4857 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异葫芦素 B; Isocucurbitacin B CFN91003 17278-28-3 C32H46O8 = 558.7 10mg QQ客服:1413575084
    葫芦素B; Cucurbitacin B CFN99129 6199-67-3 C32H46O8 = 558.70 20mg QQ客服:1457312923
    葫芦素B 2-O-Beta-D-葡萄糖苷; Cucurbitacin B 2-O-beta-D-glucoside CFN92141 65247-27-0 C38H56O13 = 720.9 5mg QQ客服:2159513211
    葫芦素A; Cucurbitacin A CFN90324 6040-19-3 C32H46O9 = 574.71 5mg QQ客服:3257982914
    葫芦素I ; Cucurbitacin I CFN70316 2222-07-3 C30H42O7 = 514.7 5mg QQ客服:1457312923
    葫芦素E; Cucurbitacin E CFN90154 18444-66-1 C32H44O8 = 556.67 20mg QQ客服:2056216494
    葫芦素S; 雪胆素甲; Cucurbitacin S CFN90535 60137-06-6 C30H42O6 = 498.65 5mg QQ客服:215959384
    四氢异葫芦素I; Tetrahydroisocucurbitacin I CFN92892 3877-89-2 C30H46O7 = 518.68 5mg QQ客服:3257982914
    葫芦素 IIa; 雪胆素甲; Cucurbitacin IIA CFN98171 58546-34-2 C32H50O8 = 562.73 20mg QQ客服:1413575084
    葫芦素Q1; Cucurbitacin Q1 CFN91760 99530-82-2 C32H48O8 = 560.72 10mg QQ客服:1457312923

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