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  • 异葫芦素 D

    Isocucurbitacin D

    异葫芦素 D
    产品编号 CFN95326
    CAS编号 68422-20-8
    分子式 = 分子量 C30H44O7 = 516.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Trichosanthes cucumeroides
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异葫芦素 D CFN95326 68422-20-8 1mg QQ客服:2056216494
    异葫芦素 D CFN95326 68422-20-8 5mg QQ客服:2056216494
    异葫芦素 D CFN95326 68422-20-8 10mg QQ客服:2056216494
    异葫芦素 D CFN95326 68422-20-8 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antiviral Res.2021, 193:105142.
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  • Ind Crops Prod.2015, 67:185-191
  • Viruses.2021, 13(11):2118.
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  • ...
  • 生物活性
    Description: Isocucurbitacin D showed a cytotoxic effect with disruption of target protein cofilin. Isocucurbitacin D exhibited the highest activities of improved the LDL uptake rate.Isocucurbitacin D dose-dependently increased LDLR protein levels and decreased PCSK9 protein levels.
    In vitro:
    J Nat Prod., 2020 Dec 24;83(12):3536-3544.
    Lipid-Lowering Activities of Cucurbitacins Isolated from Trichosanthes cucumeroides and Their Synthetic Derivatives[Pubmed: 33269591]
    In the ongoing efforts to discover natural cholesterol-lowering compounds, dihydrocucurbitacin B, isolated from Trichosanthes cucumeroides roots, was found to promote LDL uptake by upregulating LDLR protein in a PCSK9-dependent process. In this study, an in-depth investigation of T. cucumeroides roots afforded 27 cucurbitacins (1-27), including seven new cucurbitacins (1-7), and their structures were elucidated by spectroscopic data analyses. In order to gain insight into their structure-activity relationship, cucurbitacin derivatives (B1-11 and DB1-11) were synthesized. Evaluation of lipid-lowering activities of these cucurbitacins by an LDL uptake assay in HepG2 cells revealed that most of the compounds improved the LDL uptake rate, among which hexanorisocucurbitacin D (6) and isocucurbitacin D (21) exhibited the highest activities (rates of 2.53 and 2.47, respectively), which were comparable to that of the positive control, nagilactone B (rate of 2.07). According to a mechanistic study by Western blot analysis, compounds 6 and 21 dose-dependently increased LDLR protein levels and reduced PCSK9 protein levels, representing promising new lipid-lowering drug candidates.
    Toxins (Basel). 2022 Mar 16;14(3):212.
    Analysis of Active Compounds Using Target Protein Cofilin-Cucurbitacins in Cytotoxic Plant Bryonia cretica[Pubmed: 35324709]
    We examined a two-step target protein binding strategy that uses cofilin as the target protein to analyze the active constituents in Bryonia cretica. In the first step, we prepared the target protein, and used it to analyze the compounds binding to it in the second step. We used the methanolic extract of B. cretica as a library of possible active compounds. We conducted LC-MS analysis using information from our previous study. The peaks in the HPLC profile were identified as cucurbitacin D, isocucurbitacin D, and cucurbitacin I. As far as we know, there is no known study of the activity of isocucurbitacin D in this research field. Therefore, we examined the effects of isocucurbitacin D on cell proliferation and cofilin protein in human fibrosarcoma cell line HT1080 to confirm the effectiveness of this strategy. The cytotoxicity assay, the fibrous/globular actin ratio assay, and the immunoblotting analysis revealed that isocucurbitacin D showed a cytotoxic effect with disruption of target protein cofilin. The target protein binding strategy is a direct and straightforward method for finding new drug seeds from crude sources, such as natural plant extracts.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9354 mL 9.6768 mL 19.3536 mL 38.7072 mL 48.384 mL
    5 mM 0.3871 mL 1.9354 mL 3.8707 mL 7.7414 mL 9.6768 mL
    10 mM 0.1935 mL 0.9677 mL 1.9354 mL 3.8707 mL 4.8384 mL
    50 mM 0.0387 mL 0.1935 mL 0.3871 mL 0.7741 mL 0.9677 mL
    100 mM 0.0194 mL 0.0968 mL 0.1935 mL 0.3871 mL 0.4838 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    葫芦素B 2-O-Beta-D-葡萄糖苷; Cucurbitacin B 2-O-beta-D-glucoside CFN92141 65247-27-0 C38H56O13 = 720.9 5mg QQ客服:1457312923
    葫芦素A; Cucurbitacin A CFN90324 6040-19-3 C32H46O9 = 574.71 5mg QQ客服:1413575084
    葫芦素I ; Cucurbitacin I CFN70316 2222-07-3 C30H42O7 = 514.7 5mg QQ客服:1413575084
    葫芦素E; Cucurbitacin E CFN90154 18444-66-1 C32H44O8 = 556.67 20mg QQ客服:1457312923
    葫芦素S; 雪胆素甲; Cucurbitacin S CFN90535 60137-06-6 C30H42O6 = 498.65 5mg QQ客服:2056216494
    四氢异葫芦素I; Tetrahydroisocucurbitacin I CFN92892 3877-89-2 C30H46O7 = 518.68 5mg QQ客服:1413575084
    葫芦素 IIa; 雪胆素甲; Cucurbitacin IIA CFN98171 58546-34-2 C32H50O8 = 562.73 20mg QQ客服:215959384
    葫芦素Q1; Cucurbitacin Q1 CFN91760 99530-82-2 C32H48O8 = 560.72 10mg QQ客服:3257982914
    葫芦素R; Cucurbitacin R CFN92895 55903-92-9 C30H46O7 = 518.68 5mg QQ客服:2056216494
    二氢葫芦素B; Dihydrocucurbitacin B CFN92140 13201-14-4 C32H48O8 = 560.7 10mg QQ客服:1413575084

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