3'-二甲基烯丙基染料木黄酮

Isowighteone

	产品编号	CFN97166
	CAS编号	68436-47-5
	分子式 = 分子量	C₂₀H₁₈O₅ = 338.4
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Flavonoids
	植物来源	The roots of Sophora flavescens.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
3'-二甲基烯丙基染料木黄酮	CFN97166	68436-47-5	1mg	QQ客服：1457312923
3'-二甲基烯丙基染料木黄酮	CFN97166	68436-47-5	5mg	QQ客服：1457312923
3'-二甲基烯丙基染料木黄酮	CFN97166	68436-47-5	10mg	QQ客服：1457312923
3'-二甲基烯丙基染料木黄酮	CFN97166	68436-47-5	20mg	QQ客服：1457312923

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

The University of Newcastle (Australia)

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Shanghai Institute of Organic Chemistry (China)

University of Hawaii Cancer Center (USA)

Ain Shams University (Egypt)

Vin?a Institute of Nuclear Sciences (Serbia)

University of Bonn (Germany)

Korea Food Research Institute(KFRI) (Korea)

University of Parma (Italy)

Chang Gung University (Taiwan)

Universidade do Porto (Portugal)

Mahidol University (Thailand)

Universiti Sains Malaysia (Malaysia)

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Description:

Isowighteone, a compound that is not naturally produced in this species, accumulated by medicago truncatula hairy roots expressing LaPT1, indicates a strategy for metabolic engineering of novel antimicrobial compounds in legumes; it may have antimicrobial activity against fungal pathogens of plants.

Targets:

Antifection

In vitro:

Plant Physiol. 2012 May;159(1):70-80.

Characterization of an isoflavonoid-specific prenyltransferase from Lupinus albus.[Pubmed: 22430842]

Prenylated flavonoids and isoflavonoids possess antimicrobial activity against fungal pathogens of plants. However, only a few plant flavonoid and isoflavonoid prenyltransferase genes have been identified to date.
METHODS AND RESULTS:
In this study, an isoflavonoid prenyltransferase gene, designated as LaPT1, was identified from white lupin (Lupinus albus). The deduced protein sequence of LaPT1 shared high homologies with known flavonoid and isoflavonoid prenyltransferases. The LaPT1 gene was mainly expressed in roots, a major site for constitutive accumulation of prenylated isoflavones in white lupin. LaPT1 is predicted to be a membrane-bound protein with nine transmembrane regions and conserved functional domains similar to other flavonoid and isoflavonoid prenyltransferases; it has a predicted chloroplast transit peptide and is plastid localized. A microsomal fraction containing recombinant LaPT1 prenylated the isoflavone genistein at the B-ring 3' position to produce Isowighteone. The enzyme is also active with 2'-hydroxygenistein but has no activity with other flavonoid substrates. The apparent K(m) of recombinant LaPT1 for the dimethylallyl diphosphate prenyl donor is in a similar range to that of other flavonoid prenyltransferases, but the apparent catalytic efficiency with genistein is considerably higher. Removal of the transit peptide increased the apparent overall activity but also increased the K(m).
CONCLUSIONS:
Medicago truncatula hairy roots expressing LaPT1 accumulated Isowighteone, a compound that is not naturally produced in this species, indicating a strategy for metabolic engineering of novel antimicrobial compounds in legumes.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
甘草异黄酮 B; Licoisoflavone B	CFN96405	66056-30-2	C₂₀H₁₆O₆ = 352.4	5mg	QQ客服：2159513211
西北甘草异黄酮; Glycyrrhisoflavone	CFN90817	116709-70-7	C₂₀H₁₈O₆ = 354.4	10mg	QQ客服：3257982914
半甘草异黄酮 B; Semilicoisoflavone B	CFN90818	129280-33-7	C₂₀H₁₆O₆ = 352.3	5mg	QQ客服：2159513211
甘草瑞酮; Glicoricone	CFN95063	161099-37-2	C₂₁H₂₀O₆ = 368.4	5mg	QQ客服：2056216494
甘草利酮; Licoricone	CFN96504	51847-92-8	C₂₂H₂₂O₆ = 382.41	5mg	QQ客服：3257982914
异新补骨脂异黄酮; Isoneobavaisoflavone	CFN92223	40357-43-5	C₂₀H₁₈O₄ = 322.4	5mg	QQ客服：1457312923
光甘草酮; Glabrone	CFN93041	60008-02-8	C₂₀H₁₆O₅ = 336.34	5mg	QQ客服：1413575084
新补骨脂异黄酮; Neobavaisoflavone	CFN92222	41060-15-5	C₂₀H₁₈O₄ = 322.4	20mg	QQ客服：3257982914
3'-二甲基烯丙基染料木黄酮; Isowighteone	CFN97166	68436-47-5	C₂₀H₁₈O₅ = 338.4	5mg	QQ客服：1413575084
Isoderrone; Isoderrone	CFN92794	121747-89-5	C₂₀H₁₆O₅ = 336.3	5mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9551 mL	14.7754 mL	29.5508 mL	59.1017 mL	73.8771 mL
5 mM	0.591 mL	2.9551 mL	5.9102 mL	11.8203 mL	14.7754 mL
10 mM	0.2955 mL	1.4775 mL	2.9551 mL	5.9102 mL	7.3877 mL
50 mM	0.0591 mL	0.2955 mL	0.591 mL	1.182 mL	1.4775 mL
100 mM	0.0296 mL	0.1478 mL	0.2955 mL	0.591 mL	0.7388 mL