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  • 甘草利酮

    Licoricone

    甘草利酮
    产品编号 CFN96504
    CAS编号 51847-92-8
    分子式 = 分子量 C22H22O6 = 382.41
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Glycyrrhiza uralensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    甘草利酮 CFN96504 51847-92-8 1mg QQ客服:1413575084
    甘草利酮 CFN96504 51847-92-8 5mg QQ客服:1413575084
    甘草利酮 CFN96504 51847-92-8 10mg QQ客服:1413575084
    甘草利酮 CFN96504 51847-92-8 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • S.N.D.T. Women's University (India)
  • Ateneo de Manila University (Philippines)
  • University of Wuerzburg (Germany)
  • Institute of Chinese Materia Medica (China)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Chang Gung University (Taiwan)
  • University of Toronto (Canada)
  • Utah State University (USA)
  • Imperial College London (United Kingdom)
  • University of Wisconsin-Madison (USA)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Medical University of South Carolina (USA)
  • Indian Institute of Science (India)
  • Center for protein Engineering (CIP) (Belgium)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Pharm Biol.2021, 59(1):134-145.
  • Appl. Sci.2020, 10(8),2804
  • Molecules.2020, 25(11):2599.
  • Anticancer Res.2020, 40(10):5529-5538.
  • ACS Synth Biol.2022, doi: 10.1021.
  • Appl Biochem Biotechnol.2022, s12010-022-04166-2.
  • South African J of Botany2020, 135:50-57
  • Drug Chem Toxicol.2020, 1-14.
  • JPC-Journal of Planar Chromatography 2017, 30(2)
  • Anticancer Res.2014, 34(7):3505-9
  • Biomolecules.2021, 11(10):1537.
  • Biomed Sci Letters.2020, 26:319-326
  • Food Chem.2020, 313:126079
  • Nutrients.2018, 10(7)
  • Horticulturae2023, 9(2), 213.
  • J Microbiol Biotechnol.2022, 32(2):141-148.
  • Sci Rep.2019, 9(1):18080
  • Institute of Food Science & Technology2021, 45(9).
  • Biomed Chromatogr.2016, 30(10):1573-81
  • Food Chemistry: X2023, 101032.
  • Front Plant Sci.2022, 12:811166.
  • Korean Journal of Pharmacognosy2018, 49(1):76-83
  • J Pharmaceut Biomed2020, 178:112894
  • ...
  • 生物活性
    Description: Licoricone exhibits anti-helicobacter pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains.
    Targets: Antifection
    In vitro:
    Life Sci. 2002 Aug 9;71(12):1449-63.
    Anti-Helicobacter pylori flavonoids from licorice extract.[Pubmed: 12127165]
    Licorice is the most used crude drug in Kampo medicines (traditional Chinese medicines modified in Japan). The extract of the medicinal plant is also used as the basis of anti-ulcer medicines for treatment of peptic ulcer.
    METHODS AND RESULTS:
    Among the chemical constituents of the plant, glabridin and glabrene (components of Glycyrrhiza glabra), licochalcone A (G. inflata), licoricidin and licoisoflavone B (G. uralensis) exhibited inhibitory activity against the growth of Helicobacter pylori in vitro. These flavonoids also showed anti-H. pylori activity against a clarithromycin (CLAR) and amoxicillin (AMOX)-resistant strain. We also investigated the methanol extract of G. uralensis. From the extract, three new isoflavonoids (3-arylcoumarin, pterocarpan, and isoflavan) with a pyran ring, gancaonols A[bond]C, were isolated together with 15 known flavonoids. Among these compounds, vestitol, licoricone, 1-methoxyphaseollidin and gancaonol C exhibited anti-H. pylori activity against the CLAR and AMOX-resistant strain as well as four CLAR (AMOX)-sensitive strains. Glycyrin, formononetin, isolicoflavonol, glyasperin D, 6,8-diprenylorobol, gancaonin I, dihydrolicoisoflavone A, and gancaonol B possessed weaker anti-H. pylori activity.
    CONCLUSIONS:
    These compounds may be useful chemopreventive agents for peptic ulcer or gastric cancer in H. pylori-infected individuals.
    Future Microbiol. 2015;10(12):1953-68.
    Attenuation of quorum sensing-mediated virulence of Acinetobacter baumannii by Glycyrrhiza glabra flavonoids.[Pubmed: 26582430 ]
    To develop an alternative quorum quenching therapy against multidrug-resistant Acinetobacter baumannii.
    METHODS AND RESULTS:
    Activity-guided partially purified fraction (F1) from Glycyrrhiza glabra significantly (p < 0.05) reduced quorum sensing regulated virulence factors of A. baumannii viz. motility, biofilm formation and production of antioxidant enzymes. Mechanistically, F1 downregulated the expression of autoinducer synthase gene, abaI, and consequently reduced (92%) the production of 3-OH-C12-HSL as determined by ESI-MS. Q-TOF and Q-TRAP analyses suggested the presence of flavonoids viz. licoricone, glycyrin and glyzarin as the active ingredients.
    CONCLUSIONS:
    This is the first report on quorum quenching activity of G. glabra linked to its flavonoids that downregulated the expression of abaI and attenuated quorum sensing regulated virulence of A. baumannii.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.615 mL 13.075 mL 26.1499 mL 52.2999 mL 65.3749 mL
    5 mM 0.523 mL 2.615 mL 5.23 mL 10.46 mL 13.075 mL
    10 mM 0.2615 mL 1.3075 mL 2.615 mL 5.23 mL 6.5375 mL
    50 mM 0.0523 mL 0.2615 mL 0.523 mL 1.046 mL 1.3075 mL
    100 mM 0.0261 mL 0.1307 mL 0.2615 mL 0.523 mL 0.6537 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    甘草异黄酮 B; Licoisoflavone B CFN96405 66056-30-2 C20H16O6 = 352.4 5mg QQ客服:2056216494
    西北甘草异黄酮; Glycyrrhisoflavone CFN90817 116709-70-7 C20H18O6 = 354.4 10mg QQ客服:1413575084
    半甘草异黄酮 B; Semilicoisoflavone B CFN90818 129280-33-7 C20H16O6 = 352.3 5mg QQ客服:2159513211
    甘草瑞酮; Glicoricone CFN95063 161099-37-2 C21H20O6 = 368.4 5mg QQ客服:2159513211
    甘草利酮; Licoricone CFN96504 51847-92-8 C22H22O6 = 382.41 5mg QQ客服:215959384
    异新补骨脂异黄酮; Isoneobavaisoflavone CFN92223 40357-43-5 C20H18O4 = 322.4 5mg QQ客服:1457312923
    光甘草酮; Glabrone CFN93041 60008-02-8 C20H16O5 = 336.34 5mg QQ客服:1413575084
    新补骨脂异黄酮; Neobavaisoflavone CFN92222 41060-15-5 C20H18O4 = 322.4 20mg QQ客服:1413575084
    3'-二甲基烯丙基染料木黄酮; Isowighteone CFN97166 68436-47-5 C20H18O5 = 338.4 5mg QQ客服:215959384
    Isoderrone; Isoderrone CFN92794 121747-89-5 C20H16O5 = 336.3 5mg QQ客服:2056216494

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