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  • 甘草瑞酮

    Glicoricone

    甘草瑞酮
    产品编号 CFN95063
    CAS编号 161099-37-2
    分子式 = 分子量 C21H20O6 = 368.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Glycyrrhiza uralensis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    甘草瑞酮 CFN95063 161099-37-2 1mg QQ客服:2932563308
    甘草瑞酮 CFN95063 161099-37-2 5mg QQ客服:2932563308
    甘草瑞酮 CFN95063 161099-37-2 10mg QQ客服:2932563308
    甘草瑞酮 CFN95063 161099-37-2 20mg QQ客服:2932563308
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Illinois (USA)
  • Biotech R&D Institute (USA)
  • St. Jude Children Research Hospital (USA)
  • Instituto Politécnico de Bragan?a (Portugal)
  • University of Liège (Belgium)
  • Georgia Institute of Technology (USA)
  • Institute of Pathophysiology Medical University of Vienna (Austria)
  • Ateneo de Manila University (Philippines)
  • Hamdard University (India)
  • Wageningen University (Netherlands)
  • University of Indonesia (Indonesia)
  • University of Vigo (Spain)
  • Universite Libre de Bruxelles (Belgium)
  • CSIRO - Agriculture Flagship (Australia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Industrial Food Engineering2015, 19(4):408-413
  • Int. J. of Pha. and Phy. Res.2015, 7(1):144-149
  • Am J Chin Med.2016, 44(8):1719-1735
  • Universidade Estadual Paulista2017, 11449
  • PLoS One.2017, 12(3):e0173585
  • Semyung University2017, 149407
  • BMC Complement Altern Med.2017, 17(1):393
  • Int J Mol Sci.2017, 18(12)
  • Evid Based Complement Alternat Med.2017, 2017:9764843
  • Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083
  • J Nat Med.2017, 71(2):457-462
  • Front Immunol.2017, 8:1542
  • Drug Test Anal.2018, 10(10):1579-1589
  • Nutrients.2018, 10(12)
  • Biofactors.2018, 44(2):168-179
  • BMB Rep.2018, 51(5):249-254
  • Plant Cell Physiol.2018, 59(1):128-141
  • Int J Mol Sci.2019, 21(1):E265
  • Phytomedicine.2019, 56:48-56
  • Phytomedicine.2019, 67:153159
  • Process Biochemistry2019, 87:213-220
  • Food Chem Toxicol.2020, 135:110863
  • Pharmacological Reports2020, 1-9
  • ...
  • 生物活性
    Description: Glicoricone acts as a partial estrogen antagonist. Glicoricone inhibited the monoamine oxidase with the IC50 values of 6.0 x 10(-5)-1.4 x 10(-4) M.
    Targets: Estrogen receptor | MAO | Progestogen receptor
    In vitro:
    Steroids. 2016 Jan;105:42-9.
    Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities.[Pubmed: 26631549]
    Licorice root extracts are often consumed as botanical dietary supplements by menopausal women as a natural alternative to pharmaceutical hormone replacement therapy. In addition to their components liquiritigenin (Liq) and isoliquiritigenin (Iso-Liq), known to have estrogenic activity, licorice root extracts also contain a number of other flavonoids, isoflavonoids, and chalcones.
    METHODS AND RESULTS:
    We have investigated the estrogenic activity of 7 of these components, obtained from an extract of Glycyrrhiza glabra powder, namely Glabridin (L1), Calycosin (L2), Methoxychalcone (L3), Vestitol (L4), Glyasperin C (L5), Glycycoumarin (L6), and Glicoricone (L7), and compared them with Liq, Iso-Liq, and estradiol (E2). All components, including Liq and Iso-Liq, have low binding affinity for estrogen receptors (ERs). Their potency and efficacy in stimulating the expression of estrogen-regulated genes reveal that Liq and Iso-Liq and L2, L3, L4, and L6 are estrogen agonists. Interestingly, L3 and L4 have an efficacy nearly equivalent to E2 but with a potency ca. 10,000-fold less. The other components, L1, L5 and L7, acted as partial estrogen antagonists. All agonist activities were reversed by the antiestrogen, ICI 182,780, or by knockdown of ERα with siRNA, indicating that they are ER dependent. In HepG2 hepatoma cells stably expressing ERα, only Liq, Iso-Liq, and L3 stimulated estrogen-regulated gene expression, and in all cases gene stimulation did not occur in HepG2 cells lacking ERα.
    CONCLUSIONS:
    Collectively, these findings classify the components of licorice root extracts as low potency, mixed ER agonists and antagonists, having a character akin to that of selective estrogen receptor modulators or SERMs.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.7144 mL 13.5722 mL 27.1444 mL 54.2888 mL 67.861 mL
    5 mM 0.5429 mL 2.7144 mL 5.4289 mL 10.8578 mL 13.5722 mL
    10 mM 0.2714 mL 1.3572 mL 2.7144 mL 5.4289 mL 6.7861 mL
    50 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.0858 mL 1.3572 mL
    100 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.5429 mL 0.6786 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3'-二甲基烯丙基染料木黄酮; Isowighteone CFN97166 68436-47-5 C20H18O5 = 338.4 5mg QQ客服:1148253675
    Isoderrone; Isoderrone CFN92794 121747-89-5 C20H16O5 = 336.3 5mg QQ客服:3257982914
    黄甘草异黄酮A; Eurycarpin A CFN97806 166547-20-2 C20H18O5 = 338.36 5mg QQ客服:2932563308
    甘草异黄酮A; Licoisoflavone A CFN90816 66056-19-7 C20H18O6 = 354.4 5mg QQ客服:1413575084
    甘草异黄酮 B; Licoisoflavone B CFN96405 66056-30-2 C20H16O6 = 352.4 5mg QQ客服:2932563308
    西北甘草异黄酮; Glycyrrhisoflavone CFN90817 116709-70-7 C20H18O6 = 354.4 10mg QQ客服:215959384
    半甘草异黄酮 B; Semilicoisoflavone B CFN90818 129280-33-7 C20H16O6 = 352.3 5mg QQ客服:215959384
    甘草瑞酮; Glicoricone CFN95063 161099-37-2 C21H20O6 = 368.4 5mg QQ客服:1413575084
    甘草利酮; Licoricone CFN96504 51847-92-8 C22H22O6 = 382.41 5mg QQ客服:3257982914
    异新补骨脂异黄酮; Isoneobavaisoflavone CFN92223 40357-43-5 C20H18O4 = 322.4 5mg QQ客服:215959384

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