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  • 新补骨脂异黄酮

    Neobavaisoflavone

    新补骨脂异黄酮
    产品编号 CFN92222
    CAS编号 41060-15-5
    分子式 = 分子量 C20H18O4 = 322.4
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The seeds of Psoralea corylifolia L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    新补骨脂异黄酮 CFN92222 41060-15-5 10mg QQ客服:2159513211
    新补骨脂异黄酮 CFN92222 41060-15-5 20mg QQ客服:2159513211
    新补骨脂异黄酮 CFN92222 41060-15-5 50mg QQ客服:2159513211
    新补骨脂异黄酮 CFN92222 41060-15-5 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Copenhagen University (Denmark)
  • University of Toulouse (France)
  • Universite Libre de Bruxelles (Belgium)
  • The Institute of Cancer Research (United Kingdom)
  • University of Vienna (Austria)
  • Regional Crop Research Institute (Korea)
  • Complutense University of Madrid (Spain)
  • National Research Council of Canada (Canada)
  • Weizmann Institute of Science (Israel)
  • Subang Jaya Medical Centre (Malaysia)
  • Universidade do Porto (Portugal)
  • Medical University of South Carolina (USA)
  • Indian Institute of Science (India)
  • Johannes Gutenberg University Mainz (JGU) (Germany)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Sci Nutr.2019, 8(1):246-256
  • BMC Cancer. 2021, 21(1):91.
  • J Hepatocell Carcinoma.2022, 9:327-341.
  • Microchemical Journal2024: 196:109676.
  • World J Mens Health.2019, 10.5534
  • Srinagarind Medical Journal2017, 32(1)
  • Univerzita Karlova2022, 228192.
  • Food Science and Human Wellness2022, 11(4):965-974
  • J Cell Mol Med.2023, jcmm.18071.
  • British Jou. Med.&Med. Research2014, 1802-1811
  • Drug Des Devel Ther.2020, 14:5189-5204.
  • Molecules.2016, 21(6)
  • J of Pharmaceutical Analysis2020, doi: 10.1016
  • Chemistry of plant raw materials2021, 1:pp 139-150
  • J Cell Physiol.2020, 10.1002
  • Preprints2017, 2017120176
  • Ann Transl Med.2019, 7(23):731
  • Institute of Food Science & Technology2021, 18 December.
  • Int J Food Sci Nutr.2019, 70(7):825-833
  • Nutrients.2023, 15(3):753.
  • Agronomy2023, 13(6), 1435.
  • Chem Biol Interact.2018, 283:59-74
  • Comput Biol Chem.2019, 83:107096
  • ...
  • 生物活性
    Description: Neobavaisoflavone, exhibits inhibitory activity against DNA polymerase and platelet aggregation, it also has striking anti-inflammatory and anti-cancer effects, Neobavaisoflavone can significantly inhibit the production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and cytokines: IL-1β, IL-6, IL-12p40, IL-12p70, TNF-α in LPS+IFN-γ- or PMA- stimulated RAW264.7 macrophages.
    Targets: ROS | IL Receptor | TNF-α | IFN-γ | p53 | Caspase | Bcl-2/Bax | p38MAPK
    In vitro:
    Phytomedicine. 2014 Apr 15;21(5):682-8.
    Activity of three cytotoxic isoflavonoids from Erythrina excelsa and Erythrina senegalensis (neobavaisoflavone, sigmoidin H and isoneorautenol) toward multi-factorial drug resistant cancer cells.[Pubmed: 24252341 ]
    Resistance of cancer cells to chemotherapy has become a worldwide concern. Naturally occuring isoflavonoids possess a variety of biological activities including anti-cancer effects. The present study was aimed at investigating the cytotoxicity and the modes of action of three naturally occuring isoflavonoids, neobavaisoflavone (1), sigmoidin H (2) and a pterocarpan that is a special type of isoflavonoid, isoneorautenol (3) against a panel of nine cancer cell lines, including various sensitive and drug-resistant phenotypes.
    METHODS AND RESULTS:
    The cytotoxicity of the compounds was determined using a resazurin reduction assay, whereas the caspase-Glo assay was used to detect the activation of caspases 3/7, caspase 8 and caspase 9 in cells treated with compounds 3. Flow cytometry was used for cell cycle analysis and detection of apoptotic cells, analysis of mitochondrial membrane potential (MMP) as well as measurement of reactive oxygen species (ROS). Compounds 3 showed significant cytotoxicity toward sensitive and drug-resistant cancer cell lines. Compounds 1 and 2 were selectively active, and IC50 values below 115 μM were obtained on 6/9 and 4/9 cell lines respectively with values ranging from 42.93 μM (toward CCRF-CEM cells) to 114.64 μM [against HCT116 (p53(+/+)) cells] for 1 and 25.59 μM (toward U87MG) to 110.51 μM [against HCT116 (p53(+/+)) cells] for 2. IC50 values ranging from 2.67 μM (against MDA-MB 237BCRP cells) to 21.84 (toward U87MG) were measured for compound 3 and between 0.20 μM (toward CCRF-CEM cells) and 195.12 μM (toward CEM/ADR5000 cells) for doxorubicin as control drug. BCRP-transfected MDA-MB-231 cells, HCT116 (p53(+/+)) and U87MG.ΔEGFR cells were hypersensitive (collateral sensitive) to compound 3 as compared to their counterpart cell lines. Compound 3 induced apoptosis in CCRF-CEM cells via activation of caspases 3/7, 8 and 9 as well as the loss of MMP and increased ROS production.
    CONCLUSIONS:
    The cytotoxicity of the studied isoflavonoids and especially the pterocarpan 3 deserve more detailed exploration in the future to develop novel anticancer drugs against sensitive and otherwise drug-resistant phenotypes.
    Life Sci. 2014 Jan 30;95(2):101-7.
    Neobavaisoflavone sensitizes apoptosis via the inhibition of metastasis in TRAIL-resistant human glioma U373MG cells.[Pubmed: 24231449]
    Neobavaisoflavone (NBIF), an isoflavone isolated from Psoralea corylifolia (Leguminosae), has striking anti-inflammatory and anti-cancer effects. Neobavaisoflavone inhibits the proliferation of prostate cancer in vitro and in vivo.
    METHODS AND RESULTS:
    In this study, we found that Neobavaisoflavone sensitizes human U373MG glioma cells to TRAIL-mediated apoptosis. Co-treatment of TRAIL and Neobavaisoflavone effectively induced Bid cleavage and activated caspases 3, 8, and 9. Importantly, DR5 expression was upregulated by Neobavaisoflavone. We also observed that the combination Neobavaisoflavone and TRAIL increased expression of BAX. We further demonstrate that Neobavaisoflavone induced TRAIL-mediated apoptosis in human glioma cells by suppressing migration and invasion, and by inhibiting anoikis resistance.
    CONCLUSIONS:
    Taken together, our results suggest that Neobavaisoflavone reduces the resistance of cancer cells to TRAIL and that the combination of Neobavaisoflavone and TRAIL may be a new therapeutic strategy for treating TRAIL-resistant glioma cells.
    Molecules. 2011 May 3;16(5):3701-12.
    Inhibition of inflammatory mediators by neobavaisoflavone in activated RAW264.7 macrophages.[Pubmed: 21540797]
    Flavonoids and coumarins are the major bioactive constituents identified in Psoralea corylifolia. The active fraction isolated from fruits, seeds and roots possesses antibacterial, antioxidative and immunomodulatory properties. Neobavaisoflavone is one of the flavonoids found in Psoralea corylifolia. In the present study we investigated in vitro the anti-inflammatory activity of neobavaisoflavone.
    METHODS AND RESULTS:
    Macrophages play an important role in inflammation through the release of inflammatory mediators involved in the immune response. Inappropriate and prolonged macrophage activation is largely responsible for the pathology of acute and chronic inflammatory conditions. Neobavaisoflavone significantly inhibited the production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and cytokines: IL-1β, IL-6, IL-12p40, IL-12p70, TNF-α in LPS+IFN-γ- or PMA- stimulated RAW264.7 macrophages.
    J Cell Mol Med . 2020 Aug;24(16):9067-9084.
    Neobavaisoflavone inhibits osteoclastogenesis through blocking RANKL signalling-mediated TRAF6 and c-Src recruitment and NF-κB, MAPK and Akt pathways[Pubmed: 32604472]
    Abstract Psoralea corylifolia (P corylifolia) has been popularly applied in traditional Chinese medicine decoction for treating osteoporosis and promoting fracture healing since centuries ago. However, the bioactive natural components remain unknown. In this study, applying comprehensive two-dimensional cell membrane chromatographic/C18 column/time-of-flight mass spectrometry (2D CMC/C18 column/TOFMS) system, neobavaisoflavone (NBIF), for the first time, was identified for the bioaffinity with RAW 264.7 cells membranes from the extracts of P corylifolia. Here, we revealed that NBIF inhibited RANKL-mediated osteoclastogenesis in bone marrow monocytes (BMMCs) and RAW264.7 cells dose dependently at the early stage. Moreover, NBIF inhibited osteoclasts function demonstrated by actin ring formation assay and pit-formation assay. With regard to the underlying molecular mechanism, co-immunoprecipitation showed that both the interactions of RANK with TRAF6 and with c-Src were disrupted. In addition, NBIF inhibited the phosphorylation of P50, P65, IκB in NF-κB pathway, ERK, JNK, P38 in MAPKs pathway, AKT in Akt pathway, accompanied with a blockade of calcium oscillation and inactivation of nuclear translocation of nuclear factor of activated T cells cytoplasmic 1 (NFATc1). In vivo, NBIF inhibited osteoclastogenesis, promoted osteogenesis and ameliorated bone loss in ovariectomized mice. In summary, P corylifolia-derived NBIF inhibited RANKL-mediated osteoclastogenesis by suppressing the recruitment of TRAF6 and c-Src to RANK, inactivating NF-κB, MAPKs, and Akt signalling pathways and inhibiting calcium oscillation and NFATc1 translocation. NBIF might serve as a promising candidate for the treatment of osteoclast-associated osteopenic diseases.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.1017 mL 15.5087 mL 31.0174 mL 62.0347 mL 77.5434 mL
    5 mM 0.6203 mL 3.1017 mL 6.2035 mL 12.4069 mL 15.5087 mL
    10 mM 0.3102 mL 1.5509 mL 3.1017 mL 6.2035 mL 7.7543 mL
    50 mM 0.062 mL 0.3102 mL 0.6203 mL 1.2407 mL 1.5509 mL
    100 mM 0.031 mL 0.1551 mL 0.3102 mL 0.6203 mL 0.7754 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    甘草异黄酮 B; Licoisoflavone B CFN96405 66056-30-2 C20H16O6 = 352.4 5mg QQ客服:3257982914
    西北甘草异黄酮; Glycyrrhisoflavone CFN90817 116709-70-7 C20H18O6 = 354.4 10mg QQ客服:2056216494
    半甘草异黄酮 B; Semilicoisoflavone B CFN90818 129280-33-7 C20H16O6 = 352.3 5mg QQ客服:215959384
    甘草瑞酮; Glicoricone CFN95063 161099-37-2 C21H20O6 = 368.4 5mg QQ客服:1457312923
    甘草利酮; Licoricone CFN96504 51847-92-8 C22H22O6 = 382.41 5mg QQ客服:2056216494
    异新补骨脂异黄酮; Isoneobavaisoflavone CFN92223 40357-43-5 C20H18O4 = 322.4 5mg QQ客服:3257982914
    光甘草酮; Glabrone CFN93041 60008-02-8 C20H16O5 = 336.34 5mg QQ客服:2159513211
    新补骨脂异黄酮; Neobavaisoflavone CFN92222 41060-15-5 C20H18O4 = 322.4 20mg QQ客服:1413575084
    3'-二甲基烯丙基染料木黄酮; Isowighteone CFN97166 68436-47-5 C20H18O5 = 338.4 5mg QQ客服:2056216494
    Isoderrone; Isoderrone CFN92794 121747-89-5 C20H16O5 = 336.3 5mg QQ客服:2056216494

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